scholarly journals Conformational equilibria in allosteric control of Hsp70 chaperones

2021 ◽  
Vol 81 (19) ◽  
pp. 3919-3933.e7
Author(s):  
Wei Wang ◽  
Qinglian Liu ◽  
Qun Liu ◽  
Wayne A. Hendrickson
Keyword(s):  
Allosteric Control ◽  
Conformational Equilibria

The conformational equilibria and infrared matrix isolation spectra of chloroacetyl fluoride and bromoacetyl fluoride

1993 ◽  
Vol 90 ◽  
pp. 1685-1701 ◽  
Author(s):  
AA El-Bindary ◽  
A Horn ◽  
P Klaeboe ◽  
CJ Nielsen
Keyword(s):  
Matrix Isolation ◽  
Conformational Equilibria

Allosteric control of simian virus 40 T-antigen binding to viral origin DNA.

1986 ◽  
Vol 58 (3) ◽  
pp. 765-772 ◽  
Author(s):  
B Vogt ◽  
E Vakalopoulou ◽  
E Fanning
Keyword(s):  
Simian Virus 40 ◽  
Simian Virus ◽  
T Antigen ◽  
Antigen Binding ◽  
Viral Origin ◽  
Allosteric Control

ChemInform Abstract: THE CONFORMATIONAL ANALYSIS OF SATURATED HETEROCYCLES PART 56, SUBSTITUENT EFFECTS IN THE CONFORMATIONAL EQUILIBRIA OF SPIRO-OXAZOLINES

1974 ◽  
Vol 5 (20) ◽  
pp. no-no
Author(s):  
RICHARD A. Y. JONES ◽  
ALAN R. KATRITZKY ◽  
KEITH A. F. RECORD ◽  
ROGER SCATTERGOOD ◽  
JOHN M. SULLIVAN
Keyword(s):  
Conformational Analysis ◽  
Substituent Effects ◽  
Conformational Equilibria ◽  
Saturated Heterocycles

scholarly journals Rab1-AMPylation by Legionella DrrA is allosterically activated by Rab1

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Jiqing Du ◽  
Marie-Kristin von Wrisberg ◽  
Burak Gulen ◽  
Matthias Stahl ◽  
Christian Pett ◽  
...  
Keyword(s):  
Legionella Pneumophila ◽  
Adenosine Monophosphate ◽  
Vesicular Trafficking ◽  
Bacterial Protein ◽  
Post Translational Modification ◽  
Allosteric Control ◽  
Rab Protein ◽  
Biochemical Characterisation ◽  
A Site ◽  
Insight Into

AbstractLegionella pneumophila infects eukaryotic cells by forming a replicative organelle – the Legionella containing vacuole. During this process, the bacterial protein DrrA/SidM is secreted and manipulates the activity and post-translational modification (PTM) states of the vesicular trafficking regulator Rab1. As a result, Rab1 is modified with an adenosine monophosphate (AMP), and this process is referred to as AMPylation. Here, we use a chemical approach to stabilise low-affinity Rab:DrrA complexes in a site-specific manner to gain insight into the molecular basis of the interaction between the Rab protein and the AMPylation domain of DrrA. The crystal structure of the Rab:DrrA complex reveals a previously unknown non-conventional Rab-binding site (NC-RBS). Biochemical characterisation demonstrates allosteric stimulation of the AMPylation activity of DrrA via Rab binding to the NC-RBS. We speculate that allosteric control of DrrA could in principle prevent random and potentially cytotoxic AMPylation in the host, thereby perhaps ensuring efficient infection by Legionella.

CONFORMATIONAL EQUILIBRIA IN OPEN-CHAIN α,β-UNSATURATED KETONES

1961 ◽  
Vol 39 (11) ◽  
pp. 2225-2235 ◽  
Author(s):  
K. Noack ◽  
R. Norman Jones
Keyword(s):  
Raman Spectra ◽  
Equilibrium Mixture ◽  
Infrared And Raman Spectra ◽  
Temperature Dependent ◽  
Trans Form ◽  
Open Chain ◽  
Unsaturated Ketones ◽  
Conformational Isomers ◽  
Alkyl Substitution ◽  
Conformational Equilibria

The infrared and Raman spectra of trans-Δ3-penten-2-one have been measured over the temperature range +30° to −75° and +85° to +5° respectively. The temperature-dependent changes observed in the spectra indicate that this ketone exists as an equilibrium mixture of s-cis and s-trans conformational isomers in the liquid state. The s-trans form is the more stable and is present exclusively in the crystalline solid.Similar measurements have been carried out on Δ3-buten-2-one. The infrared and Raman spectra of this ketone also exhibit temperature effects that can be explained by a similar equilibrium, though the evidence is not as conclusive as for trans-Δ3-penten-2-one.The influence of alkyl substitution at the α- and β-carbon atoms on the relative stability of the s-cis and s-trans forms of α,β-unsaturated ketones is discussed.

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