The control of the complement lectin pathway activation revisited: Both C1-inhibitor and antithrombin are likely physiological inhibitors, while α2-macroglobulin is not

2013 ◽  
Vol 54 (3-4) ◽  
pp. 415-422 ◽  
Author(s):  
Katalin Paréj ◽  
József Dobó ◽  
Péter Závodszky ◽  
Péter Gál
Keyword(s):  
Lectin Pathway ◽  
C1 Inhibitor ◽  
Pathway Activation ◽  
Α2 Macroglobulin ◽  
Physiological Inhibitors

scholarly journals Regulation of the Mannan-Binding Lectin Pathway of Complement onNeisseria gonorrhoeaeby C1-Inhibitor and α2-Macroglobulin

2002 ◽  
Vol 168 (8) ◽  
pp. 4078-4086 ◽  
Author(s):  
Sunita Gulati ◽  
Kedarnath Sastry ◽  
Jens C. Jensenius ◽  
Peter A. Rice ◽  
Sanjay Ram
Keyword(s):  
Lectin Pathway ◽  
C1 Inhibitor ◽  
Α2 Macroglobulin ◽  
Mannan Binding Lectin ◽  
Binding Lectin

The Contact Phase of Blood Coagulation in Diabetes Mellitus and in Patients with Vasculopathy

1984 ◽  
Vol 52 (03) ◽  
pp. 221-223 ◽  
Author(s):  
M Christe ◽  
P Gattlen ◽  
J Fritschi ◽  
B Lämmle ◽  
W Berger ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Molecular Weight ◽  
Blood Coagulation ◽  
High Molecular Weight ◽  
Negative Correlation ◽  
Factor Xii ◽  
C1 Inhibitor ◽  
High Molecular Weight Kininogen ◽  
Contact Phase ◽  
Α2 Macroglobulin

SummaryThe contact phase has been studied in diabetics and patients with macroangiopathy. Factor XII and high molecular weight kininogen (HMWK) are normal. C1-inhibitor and also α2-macroglobulin are significantly elevated in diabetics with complications, for α1-macroglobulin especially in patients with nephropathy, 137.5% ± 36.0 (p <0.001). C1-inhibitor is also increased in vasculopathy without diabetes 113.2 ± 22.1 (p <0.01).Prekallikrein (PK) is increased in all patients’ groups (Table 2) as compared to normals. PK is particularly high (134% ± 32) in 5 diabetics without macroangiopathy but with sensomotor neuropathy. This difference is remarkable because of the older age of diabetics and the negative correlation of PK with age in normals.

Quantitative characterization of the autoactivation steps of MASP-1 and -2: Toward a kinetic model of lectin pathway activation

2011 ◽  
Vol 48 (14) ◽  
pp. 1668-1669
Author(s):  
J. Dobó ◽  
M. Megyeri ◽  
K. Szilágyi ◽  
V. Harmat ◽  
P. Závodszky ◽  
...  
Keyword(s):  
Kinetic Model ◽  
Lectin Pathway ◽  
Quantitative Characterization ◽  
Pathway Activation

Trypanosoma cruzi calreticulin inhibits the complement lectin pathway activation by direct interaction with L-Ficolin

2014 ◽  
Vol 60 (1) ◽  
pp. 80-85 ◽  
Author(s):  
Eduardo Sosoniuk ◽  
Gerardo Vallejos ◽  
Hany Kenawy ◽  
Christine Gaboriaud ◽  
Nicole Thielens ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Direct Interaction ◽  
Lectin Pathway ◽  
Pathway Activation

A new case of homozygous C1-inhibitor deficiency suggests a role for Arg378 in the control of kinin pathway activation

2010 ◽  
Vol 126 (6) ◽  
pp. 1307-1310.e3 ◽  
Author(s):  
Alberto López-Lera ◽  
Bertrand Favier ◽  
Rocío Mena de la Cruz ◽  
Sofía Garrido ◽  
Christian Drouet ◽  
...  
Keyword(s):  
C1 Inhibitor ◽  
C1 Inhibitor Deficiency ◽  
Pathway Activation

Regulation of human MBL-MASPs by C1-inhibitor and α2-macroglobulin

2000 ◽  
Vol 28 (5) ◽  
pp. A492-A492
Author(s):  
M. Kojima ◽  
R. B. Sim
Keyword(s):  
C1 Inhibitor ◽  
Α2 Macroglobulin

scholarly journals l -Ficolin binding and lectin pathway activation by acetylated low-density lipoprotein

2007 ◽  
Vol 151 (2) ◽  
pp. 275-283 ◽  
Author(s):  
J. Faro ◽  
Y. Chen ◽  
P. Jhaveri ◽  
P. Oza ◽  
G. T. Spear ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lectin Pathway ◽  
Low Density ◽  
Pathway Activation

Ficolin binding and lectin pathway activation by acetylated-LDL

2007 ◽  
Vol 44 (1-3) ◽  
pp. 168
Author(s):  
Jonathan Faro ◽  
Ying Chen ◽  
Pooja Oza ◽  
Perrin Jhaveri ◽  
Gregory T. Spear ◽  
...  
Keyword(s):  
Lectin Pathway ◽  
Pathway Activation
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