Interaction of donepezil with tau protein: Insights from surface plasmon resonance and molecular modeling methods

2021 ◽  
pp. 115924
Author(s):  
Sepideh Najar-Ahmadi ◽  
Hossein Haghaei ◽  
Safar Farajnia ◽  
Reza Yekta ◽  
Jafar Ezzati Nazhad Dolatabadi ◽  
...  
Keyword(s):  
Surface Plasmon Resonance ◽  
Molecular Modeling ◽  
Surface Plasmon ◽  
Tau Protein ◽  
Plasmon Resonance ◽  
Modeling Methods

scholarly journals Kinetic and thermodynamic study of beta-Boswellic acid interaction with Tau protein investigated by surface plasmon resonance and molecular modeling methods

Bioimpacts ◽  
2019 ◽  
Vol 10 (1) ◽  
pp. 17-25
Author(s):  
Hossein Haghaei ◽  
Seyed Rafie Aref Hosseini ◽  
Somaieh Soltani ◽  
Farzaneh Fathi ◽  
Farzad Mokhtari ◽  
...  
Keyword(s):  
Surface Plasmon Resonance ◽  
Molecular Modeling ◽  
Surface Plasmon ◽  
Tau Protein ◽  
Plasmon Resonance ◽  
Activation Barrier ◽  
Stable Complex ◽  
Boswellic Acid ◽  
Beneficial Effects ◽  
Modeling Analysis

<span style="color: #1f497d;">Introduction: Beta-Boswellic acid (BBA) is a pentacyclic terpene which has been obtained from frankincense and its beneficial effects on neurodegenerative disorders such as Alzheimer’s disease (AD) have been addressed.<br /> <span style="color: #1f497d;">Methods: In the present study, thermodynamic and kinetic aspects of BBA interaction with Tau protein as one of the important proteins involved in AD in the absence and presence of glucose has been investigated using surface plasmon resonance (SPR) method. Tau protein was immobilized onto the carboxy methyl dextran chip and its binding interactions with BBA were studied at physiological pH at various temperatures. Glucose interference with these interactions was also investigated.<br /> <span style="color: #1f497d;">Results: Results showed that BBA forms a stable complex with Tau (KD=8.45×10-7 M) at 298 K. Molecular modeling analysis showed a hydrophobic interaction between BBA and HVPGGG segment of R2 and R4 repeated domains of Tau.<br /> <span style="color: #1f497d;">Conclusion: The binding affinity increased by temperature enhancement, while it decreased significantly in the presence of glucose. Both association and dissociation of the BBA-Tau complex were accompanied with an entropic activation barrier; however, positive enthalpy and entropy changes revealed that hydrophobic bonding is the main force involved in the interaction.

Detection of Alzheimer's tau protein using localised surface plasmon resonance-based immunochip

Talanta ◽  
2008 ◽  
Vol 74 (4) ◽  
pp. 1038-1042 ◽  
Author(s):  
Mun’delanji Vestergaard ◽  
Kagan Kerman ◽  
Do-Kyun Kim ◽  
Ha Minh Hiep ◽  
Eiichi Tamiya
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Tau Protein ◽  
Plasmon Resonance

scholarly journals Characterization of Endostatin Binding to Heparin and Heparan Sulfate by Surface Plasmon Resonance and Molecular Modeling

2003 ◽  
Vol 279 (4) ◽  
pp. 2927-2936 ◽  
Author(s):  
Sylvie Ricard-Blum ◽  
Olivier Féraud ◽  
Hugues Lortat-Jacob ◽  
Anna Rencurosi ◽  
Naomi Fukai ◽  
...  
Keyword(s):  
Surface Plasmon Resonance ◽  
Molecular Modeling ◽  
Heparan Sulfate ◽  
Surface Plasmon ◽  
Plasmon Resonance

Exploring The Interactions of a Natural Gamma-Oryzanol with Human Serum Albumin: Surface Plasmon Resonance, Fluorescence, and Molecular Modeling Studies

Drug Research ◽  
2021 ◽  
Author(s):  
Somaiyeh Maleki ◽  
AmirAhmad Arabzadeh ◽  
Kazem Nejati ◽  
Farzaneh Fathi
Keyword(s):  
Surface Plasmon Resonance ◽  
Molecular Modeling ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Modeling Studies ◽  
Natural Gamma ◽  
Molecular Modeling Studies

γ-oryzanol (ORY) is the vital bioactive compound, which is a mixture of ferulic acid ester and plant sterols. In the present work, the binding of ORY to human serum albumin (HSA) was investigated at the molecular level using fluorescence spectroscopy and surface plasmon resonance (SPR) as well as molecular modeling studies. Based on the fluorescence data analysis, ORY can form a non-fluorescent complex with HSA and induce static quenching of the emission intensity of HSA. Also, the high value of K SV (34.69 × 104 M−1) confirmed a high sensitivity of HSA toward ORY. The real-time monitoring of the binding of ORY to HSA was carried out using the SPR technique. The small K D value (1.23 × 10−6 M) calculated by SPR analysis indicated a high affinity of ORY toward HSA. The molecular modeling studies confirmed that ORY has only one binding site on HSA and binds HSA in a cavity between subdomain IIA and IIIA.

Comparison of sensitivity of the refractometric methods of frustrated total internal reflection and surface plasmon resonance

2020 ◽  
pp. 44-49
Author(s):  
I. N. Pavlov
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Total Internal Reflection ◽  
Resonance Method ◽  
Internal Reflection ◽  
Optical Methods ◽  
Thin Boundary Layer ◽  
Experimental Conditions ◽  
Frustrated Total Internal Reflection

Two optical methods, namely surface plasmon resonance imaging and frustrated total internal reflection, are described in the paper in terms of comparing their sensitivity to change of refractive index of a thin boundary layer of an investigated medium. It is shown that, despite the fact that the theoretically calculated sensitivity is higher for the frustrated total internal reflection method, and the fact that usually in practice the surface plasmon resonance method, on the contrary, is considered more sensitive, under the same experimental conditions both methods show a similar result.

Surface Plasmon Resonance Based Sensitive Immunosensor for Benzaldehyde Detection

2010 ◽  
Vol 130 (7) ◽  
pp. 269-274 ◽  
Author(s):  
Takeshi Onodera ◽  
Takuzo Shimizu ◽  
Norio Miura ◽  
Kiyoshi Matsumoto ◽  
Kiyoshi Toko
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance
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