scholarly journals Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice – Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-expressing cells

2019 ◽  
Vol 29 ◽  
pp. 158-169 ◽  
Author(s):  
Lawrence J. Billing ◽  
Pierre Larraufie ◽  
Jo Lewis ◽  
Andrew Leiter ◽  
Joyce Li ◽  
...  
2014 ◽  
Vol 357 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Hyun-Jung Cho ◽  
Eliza S. Robinson ◽  
Leni R. Rivera ◽  
Paul J. McMillan ◽  
Adam Testro ◽  
...  

2010 ◽  
Vol 299 (5) ◽  
pp. G1003-G1011 ◽  
Author(s):  
Li Yang ◽  
Xiaoming Li ◽  
Yong Ji ◽  
Alison B. Kohan ◽  
David Q.-H. Wang ◽  
...  

Ezetimibe is a potent inhibitor of cholesterol absorption by enterocytes. Although ezetimibe minimally affects the absorption of triglyceride, it is unknown whether ezetimibe affects the secretion of the incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). It has been shown that ezetimibe-treated mice are protected from diet-induced insulin resistance. Since GIP and GLP-1 promote the actions of insulin, we hypothesized that ezetimibe may affect the secretion of GIP and GLP-1 by enteroendocrine cells into lymph in response to the intestinal absorption of a mixed meal (Ensure). To test this hypothesis, we used the lymph fistula rat model to determine GIP and GLP-1 concentrations in lymph during the 2 h after the infusion of Ensure. Ezetimibe significantly reduced lymphatic cholesterol output during fasting, without coincident decreases in glucose, protein, and triglyceride outputs. However, ezetimibe did not influence cholesterol output after infusion of Ensure. Interestingly, ezetimibe significantly reduced the secretion of both GIP and GLP-1 into lymph after the infusion of Ensure. Therefore, the inhibitory effect of ezetimibe on GIP and GLP-1 secretion by enteroendocrine cells occurs outside of the effects of glucose, protein, or triglyceride secretion by the intestine.


2018 ◽  
Vol 16 ◽  
pp. 65-75 ◽  
Author(s):  
Lawrence J. Billing ◽  
Christopher A. Smith ◽  
Pierre Larraufie ◽  
Deborah A. Goldspink ◽  
Sam Galvin ◽  
...  

2020 ◽  
Vol 472 (10) ◽  
pp. 1521-1532
Author(s):  
Motoshi Okumura ◽  
Akihiro Hamada ◽  
Fumina Ohsaka ◽  
Takeshi Tsuruta ◽  
Tohru Hira ◽  
...  

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