Synthesis, characterization, crystal structure, in-vitro anti-inflammatory and molecular docking studies of 5-mercapto-1-substituted tetrazole incorporated quinoline derivative

2017 ◽  
Vol 1146 ◽  
pp. 314-323 ◽  
Author(s):  
K. Sureshkumar ◽  
V. Maheshwaran ◽  
T. Dharma Rao ◽  
Khamrang Themmila ◽  
M.N. Ponnuswamy ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Molecular Docking ◽  
Docking Studies ◽  
Quinoline Derivative ◽  
Molecular Docking Studies ◽  
Anti Inflammatory

scholarly journals Synthesis and crystal structure of new monometallic Ni(ii) and Co(ii) complexes with an asymmetrical aroylhydrazone: effects of the complexes on DNA/protein binding property, molecular docking, and in vitro anticancer activity

RSC Advances ◽  
2017 ◽  
Vol 7 (78) ◽  
pp. 49404-49422 ◽  
Author(s):  
Yueqin Li ◽  
Zhiwei Yang ◽  
Minya Zhou ◽  
Yun Li
Keyword(s):  
Crystal Structure ◽  
Molecular Docking ◽  
Protein Binding ◽  
Anticancer Activity ◽  
Cobalt Complexes ◽  
Docking Studies ◽  
Binding Property ◽  
Synthesis And Crystal Structure ◽  
Molecular Docking Studies

Cytotoxic nickel and cobalt complexes containing asymmetrical aroylhydrazone were synthesized and their interactions with HS–DNA and BSA protein were investigated, which was supported by molecular docking studies.

2-Aryl-3-(2-morpholinoethyl)thiazolidin-4-ones: Synthesis, anti-inflammatory in vivo, cytotoxicity in vitro and molecular docking studies

2016 ◽  
Vol 118 ◽  
pp. 259-265 ◽  
Author(s):  
Daniela Pires Gouvea ◽  
Flávia Aleixo Vasconcellos ◽  
Gabriele dos Anjos Berwaldt ◽  
Amilton Clair Pinto Seixas Neto ◽  
Gerferson Fischer ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Docking Studies ◽  
Molecular Docking Studies ◽  
Anti Inflammatory ◽  
In Vivo Cytotoxicity

Design, Synthesis, Antioxidant, Anti-inflammatory Activity and Molecular Docking Studies of Novel 3,4,5-Trisubstituted-1,2,4-Triazole Derivatives Bearing Benzimidazole Moiety

2020 ◽  
Vol 17 ◽  
Author(s):  
Ramamurthy Katikireddy ◽  
Ramu Kakkerla ◽  
M.P.S. Murali Krishna ◽  
Gandamalla Durgaiah ◽  
Narasimha Reddy Yellu
Keyword(s):  
Molecular Docking ◽  
Docking Studies ◽  
Biological Data ◽  
Inflammatory Activity ◽  
Design Synthesis ◽  
Molecular Docking Studies ◽  
Cox 2 ◽  
Anti Inflammatory

: 5-(7-Methyl-2-propyl-1H-benzo[d]imidazol-5-yl)-4-phenyl-4H-1,2,4-triazole-3-thiols(6a-i) have been synthesized from key intermediate 7-methyl-2-propyl-1H-benzo[d]imidazole-5-carbohydrazide(3). The hydrazide was treated with different aryl isothiocyanatesto give corresponding thiosemicarbazone derivatives, which underwent cyclization in 4N sodium hydroxide to affordcorresponding title compound. All the compounds evaluated for their in vitro antioxidant and in vivo anti-inflammatory activity. From the results, compounds 6b and 6e have shown potential antioxidant and anti-inflammatory activity. The biological data was further supported by molecular docking studies, which revealed the binding pattern and the affinity of the molecules in the active site of COX-2.

Sign in / Sign up

Export Citation Format

Share Document