Novel piperazine and morpholine substituted quinolines: Selective synthesis through activation of 3,6,8-tribromoquinoline, characterization and their some metabolic enzymes inhibition potentials

2020 ◽  
Vol 1220 ◽  
pp. 128666 ◽  
Author(s):  
Osman Çakmak ◽  
Salih Ökten ◽  
Dilek Alımlı ◽  
Cem Cüneyt Ersanlı ◽  
Parham Taslimi ◽  
...  
Keyword(s):  
Metabolic Enzymes ◽  
Selective Synthesis ◽  
Substituted Quinolines ◽  
Enzymes Inhibition

Aminopyrazole-substituted metallophthalocyanines: Preparation, aggregation behavior, and investigation of metabolic enzymes inhibition properties

2019 ◽  
Vol 352 (2) ◽  
pp. 1800292 ◽  
Author(s):  
Emre Güzel ◽  
Ümit M. Koçyiğit ◽  
Barış S. Arslan ◽  
Mehmet Ataş ◽  
Parham Taslimi ◽  
...  
Keyword(s):  
Metabolic Enzymes ◽  
Aggregation Behavior ◽  
Enzymes Inhibition

Substrate selective synthesis of indole, tetrahydroquinoline and quinoline derivatives via intramolecular addition of hydrazones and imines

2018 ◽  
Vol 5 (7) ◽  
pp. 1170-1175 ◽  
Author(s):  
Rahul K. Maurya ◽  
Om P. S. Patel ◽  
Devireddy Anand ◽  
Prem P. Yadav
Keyword(s):  
Transition Metal ◽  
Selective Synthesis ◽  
Quinoline Derivatives ◽  
Metal Free ◽  
Substituted Quinolines

A transition-metal-free, substrate selective synthesis of 2,3-diaryl indoles, 4-hydrazono-tetrahydroquinolines and substituted quinolines has been developed.

Synthesis of water soluble tetra-substituted phthalocyanines: Investigation of DNA cleavage, cytotoxic effects and metabolic enzymes inhibition

2020 ◽  
Vol 1214 ◽  
pp. 128210 ◽  
Author(s):  
Armağan Günsel ◽  
Ahmet T. Bilgiçli ◽  
Burak Barut ◽  
Parham Taslimi ◽  
Arzu Özel ◽  
...  
Keyword(s):  
Dna Cleavage ◽  
Metabolic Enzymes ◽  
Water Soluble ◽  
Cytotoxic Effects ◽  
Enzymes Inhibition

Sesbania grandiflora L. Poir leaves: A dietary supplement to alleviate type 2 diabetes through metabolic enzymes inhibition

2020 ◽  
Vol 130 ◽  
pp. 282-299 ◽  
Author(s):  
Bathini Thissera ◽  
Rizliya Visvanathan ◽  
Mohammad A. Khanfar ◽  
M. Mallique Qader ◽  
Marwa H.A. Hassan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dietary Supplement ◽  
Metabolic Enzymes ◽  
Sesbania Grandiflora ◽  
Enzymes Inhibition

Imidazolinium chloride salts bearing wingtip groups: Synthesis, molecular docking and metabolic enzymes inhibition

2019 ◽  
Vol 1179 ◽  
pp. 709-718 ◽  
Author(s):  
Beyhan Yiğit ◽  
Ruya Kaya ◽  
Parham Taslimi ◽  
Yılmaz Işık ◽  
Muhammet Karaman ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Metabolic Enzymes ◽  
Enzymes Inhibition ◽  
Chloride Salts

Immunocytochemical detection of hepatic carbohydrate metabolic enzymes: Improved resolution with polyethylene glycol embedding and visio-bond semithin sections

1992 ◽  
Vol 50 (1) ◽  
pp. 792-793
Author(s):  
Kuixiong Gao ◽  
Randal E. Morris ◽  
Bruce F. Giffin ◽  
Robert R. Cardell
Keyword(s):  
Polyethylene Glycol ◽  
Glycogen Phosphorylase ◽  
Phosphoenolpyruvate Carboxykinase ◽  
Glycogen Synthase ◽  
Metabolic Enzymes ◽  
Silver Stain ◽  
Accurate Localization ◽  
Immunocytochemical Detection ◽  
Semithin Sections ◽  
Parenchymal Cells

Several enzymes are involved in the regulation of anabolic and catabolic pathways of carbohydrate metabolism in liver parenchymal cells. The lobular distribution of glycogen synthase (GS), phosphoenolpyruvate carboxykinase (PEPCK) and glycogen phosphorylase (GP) was studied by immunocytochemistry using cryosections of normal fed and fasted rat liver. Since sections of tissue embedded in polyethylene glycol (PEG) show good morphological preservation and increased detectability for immunocytochemical localization of antigenic sites, and semithin sections of Visio-Bond (VB) embedded tissue provide higher resolution of cellular structure, we applied these techniques and immunogold-silver stain (IGSS) for a more accurate localization of hepatic carbohydrate metabolic enzymes.

RetroBioCat: Computer-Aided Synthesis Planning for Biocatalytic Reactions and Cascades

2020 ◽  
Author(s):  
William Finnigan ◽  
Lorna J. Hepworth ◽  
Nicholas J. Turner ◽  
Sabine Flitsch
Keyword(s):  
Organic Chemistry ◽  
Computer Aided Design ◽  
Selective Synthesis ◽  
Test Set ◽  
Synthesis Design ◽  
Computer Aided ◽  
Synthesis Planning ◽  
Enzymatic Cascades ◽  
Target Molecules ◽  
Aided Design

As the enzyme toolbox for biocatalysis has expanded, so has the potential for the construction of powerful enzymatic cascades for efficient and selective synthesis of target molecules. Additionally, recent advances in computer-aided synthesis planning (CASP) are revolutionizing synthesis design in both synthetic biology and organic chemistry. However, the potential for biocatalysis is not well captured by tools currently available in either field. Here we present RetroBioCat, an intuitive and accessible tool for computer-aided design of biocatalytic cascades, freely available at retrobiocat.com. Our approach uses a set of expertly encoded reaction rules encompassing the enzyme toolbox for biocatalysis, and a system for identifying literature precedent for enzymes with the correct substrate specificity where this is available. Applying these rules for automated biocatalytic retrosynthesis, we show our tool to be capable of identifying promising biocatalytic pathways to target molecules, validated using a test-set of recent cascades described in the literature.

Enantioselective Synthesis of Azamerone

2018 ◽  
Author(s):  
Matthew L. Landry ◽  
Grace McKenna ◽  
Noah Burns
Keyword(s):  
Late Stage ◽  
Cross Coupling ◽  
Enantioselective Synthesis ◽  
Selective Synthesis

A concise and selective synthesis of the dichlorinated meroterpenoid azamerone is described. The paucity of tactics for the synthesis of chiral organochlorides motivated the development of unique strategies for accessing these motifs in enantioenriched forms. The route features a novel enantioselective chloroetherification reaction, a Pd-catalyzed cross-coupling between a quinone diazide and a boronic hemiester, and a late-stage tetrazine [4+2]-cycloaddition/oxidation cascade.

Enantioselective Synthesis of Azamerone

2018 ◽  
Author(s):  
Matthew L. Landry ◽  
Grace McKenna ◽  
Noah Burns
Keyword(s):  
Late Stage ◽  
Cross Coupling ◽  
Enantioselective Synthesis ◽  
Selective Synthesis

A concise and selective synthesis of the dichlorinated meroterpenoid azamerone is described. The paucity of tactics for the synthesis of chiral organochlorides motivated the development of unique strategies for accessing these motifs in enantioenriched forms. The route features a novel enantioselective chloroetherification reaction, a Pd-catalyzed cross-coupling between a quinone diazide and a boronic hemiester, and a late-stage tetrazine [4+2]-cycloaddition/oxidation cascade.

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