Background:
Ziziphus jujuba mill was commonly used for its anti-inflammatory activity
in traditional system of medicine.
Objective:
The purpose of this study was to examine the isolates of methanolic extract from the
fruits of Ziziphus jujuba Mill for its antiulcer, anti-inflammatory, and anticancer activity.
Methods:
Methanolic extracts of Ziziphus jujuba Mill were subjected to chromatography and eluted
using ethyl acetate: methanol mixture and investigated for its structural features using IR, 1H NMR,
13C NMR and mass spectral data. The isolated compound was evaluated for its in vitro COX-2 inhibition
studies, cytotoxicity studies, in vivo anti-inflammatory, antiulcer and anticancer activity.
Results:
The spectral data revealed that the backbone of the isolate was 3-O-α-L-rhamnopyranosyl-
(1→6)-β-D-glucopyranosyl jujubogenin-20-O-(2,3,4-O-triacetyl)-α-L-rhamnopyranoside. The isolated
compound showed a significant reduction in inflammation and edema. Moderate anticancer activity
was also observed for the isolate.
Conclusion:
It was concluded that the isolated saponin possesses moderate antiulcer, antiinflammatory,
and anticancer activity which could help in the identification of leads for the treatment
of cancer-related inflammation.
In vivo analysis of DNA-protein interactions on the human erythropoietin enhancer.
