Anal spindle cell lesion

Reactive multinucleated osteoclast-like giant cells (OGCs) have been described in a variety of neoplasms but rarely in gastric carcinomas. Reported herein is a case of an 81-year-old Caucasian male presented with upper abdominal pain and dysphagia. Esophagogastroscopy revealed an ulcerative mass and a specimen of subtotal gastrectomy and lower esophagectomy was sent for histologic examination. At the gastroesophageal junction an exophytic tumor, measured 2.2 cm in greatest diameter, was observed. Sections from the tumor showed gastric adenocarcinoma, stage pT1bpN0. Diffusely among the neoplastic cells multinucleated giant cells, resembling osteoclasts, were observed, which were positive for CD68, lysozyme, and vimentin and negative for AE1/AE3, CK8/18, hHCG, and LMP1. Moreover, in a random section from the gastric fundus, a spindle cell lesion, sized 0.6 cm, was revealed, which was positive for CD117 and CD34 antigens and was diagnosed as gastrointestinal stromal tumor (GIST). The presence of OGCs is an uncommon finding in gastric carcinomas and by analogy to breast and pancreatic carcinomas it could characterize a rare distinct morphological variant of gastric adenocarcinoma. Due to the limited number of the reported cases, the prognostic value of OGCs is under discussion. Furthermore, pathologists should be aware that incidental GIST may accompany any tumor.

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Malignant meningioma of the oculomotor nerve without dural attachment

Journal of Neurosurgery ◽

10.3171/jns.1998.88.6.1104 ◽

1998 ◽

Vol 88 (6) ◽

pp. 1104-1106 ◽

Cited By ~ 6

Author(s):

Alister J. Hart ◽

James Allibone ◽

Adrian T. H. Casey ◽

David G. T. Thomas

Keyword(s):

Spindle Cell ◽

Oculomotor Nerve ◽

Histological Investigation ◽

Malignant Meningioma ◽

Resonance Imaging ◽

Content Type ◽

Spindle Cell Lesion ◽

History Of ◽

Dural Attachment ◽

Fine Print

✓ Meningiomas, thought to arise from arachnoid cap cells, are usually attached to the dura. Malignancy is present in approximately 1% of these tumors. The authors report the case of a patient with a malignant meningioma arising from the oculomotor nerve with no dural attachment. The patient presented with a 7-month history of left-sided ptosis and diplopia. Magnetic resonance imaging demonstrated an extrinsic mass compressing the root of the oculomotor nerve at its exit from the midbrain. During surgery, a left-sided subtemporal approach revealed the tumor to be arising from the oculomotor nerve. Histological investigation showed a malignant spindle cell lesion with an immunohistochemical profile that was consistent with malignant meningioma. To the authors' knowledge, this is the first documented case of a malignant meningioma arising from the oculomotor nerve.

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HER2-Positive Metaplastic Spindle Cell Carcinoma Associated with Synchronous Bilateral Apocrine Carcinoma of the Breast

Case Reports in Pathology ◽

10.1155/2014/310829 ◽

2014 ◽

Vol 2014 ◽

pp. 1-5

Author(s):

Katsumi Kito ◽

Toshiharu Maeda ◽

Keiko Ninomiya ◽

Atsuro Sugita ◽

Teiri Sagawa ◽

...

Keyword(s):

Cell Carcinoma ◽

Spindle Cell ◽

Spindle Cell Carcinoma ◽

Metaplastic Carcinoma ◽

Apocrine Carcinoma ◽

Her2 Positive ◽

First Case ◽

Spindle Cell Lesion ◽

Apocrine Differentiation ◽

The Right

Apocrine carcinoma, which is strictly defined as over 90% of tumor cells showing apocrine differentiation, is a rare variant of breast cancer. Here we report an uncommon case in which apocrine carcinomas developed concurrently in both breasts; in addition, a sarcomatoid spindle cell lesion was coincident in the right breast. Both apocrine carcinomas were immunohistochemically negative for estrogen receptor (ER) and progesterone receptor (PgR), but diffusely positive for androgen receptor (AR), GCDFP-15, and HER2. The presence of intraductal components in bilateral carcinomas and the absence of lymph node metastasis suggested that they were more likely to be individual primary lesions rather than metastatic disease. The spindle cell lesion showed a relatively well-circumscribed nodule contiguous with the apocrine carcinoma. HER2 oncoprotein overexpression was observed not only in the apocrine carcinoma, but also in the spindle cell lesion. Since the spindle cell component was intimately admixed with apocrine carcinoma and had focal cytokeratin expression, we diagnosed it as metaplastic spindle cell carcinoma, which was originated from the apocrine carcinoma. To our knowledge, this is the first case report of a patient with synchronous bilateral apocrine carcinomas coinciding with metaplastic carcinoma.

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Nodular Fasciitis of the breast – An uncommon benign reactive proliferative lesion

IP Archives of Cytology and Histopathology Research ◽

10.18231/j.achr.2021.063 ◽

2021 ◽

Vol 6 (4) ◽

pp. 291-294

Author(s):

Sunil V Jagtap ◽

Vaidehi Nagar ◽

S J Bhosale ◽

Dharmesh Nagar ◽

Swati S Jagtap

Keyword(s):

Rare Case ◽

Spindle Cell ◽

Left Breast ◽

Breast Mass ◽

Nodular Fasciitis ◽

Breast Masses ◽

Surgical Department ◽

Irregular Margin ◽

Spindle Cell Lesion ◽

Proliferative Lesion

Nodular fasciitis is rarely reported in breast. It is benign reactive proliferative lesion of fibroblast. A 65 year old female presented to surgical department for left breast mass since 2 months duration, rapidly enlarging without any regional lymphadenopathy. Mammography showed hyperdensity masses with irregular margin. On FNAC reported as benign spindle cell lesion. Left sided two breast masses measuring 4 x 3.3 x 2.5cm and 2.0 x 1.6 x 0.5cm were excised and on histopathology reported as Nodular Fasciitis of left breast. We are presenting this extremely rare case of nodular fasciitis of breast for its clinical, radiological and histopathological findings.

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Enigmatic intranodal spindle cell lesion

Journal of Clinical Pathology ◽

10.1136/jclinpath-2020-206586 ◽

2020 ◽

Vol 73 (11) ◽

pp. e6-e6 ◽

Cited By ~ 1

Author(s):

Alessandro Pietro Aldera ◽

Dhirendra Govender

Keyword(s):

Spindle Cell ◽

Spindle Cell Lesion

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Enlarging Retroperitoneal Spindle Cell Lesion Masquerading as a Primary Tumor of the Liver

The American Journal of Gastroenterology ◽

10.14309/00000434-200809001-00854 ◽

2008 ◽

Vol 103 ◽

pp. S335

Author(s):

John Kalarickal ◽

David Victor ◽

Fredric Regenstein ◽

Sander Florman

Keyword(s):

Primary Tumor ◽

Spindle Cell ◽

Spindle Cell Lesion

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Multiple Gastric Antrum Mucosal Schwann Cell Hamartoma on Incidental Screening Gastroscopy: A Case Report

10.21203/rs.3.rs-257970/v1 ◽

2021 ◽

Author(s):

lu chang ◽

Jizhen Feng ◽

Zhigang Yao ◽

Shulei Zhao ◽

Xiankui Cheng ◽

...

Keyword(s):

Schwann Cell ◽

Spindle Cell ◽

Benign Lesion ◽

Final Diagnosis ◽

Gastric Antrum ◽

Gi Tract ◽

Spindle Cell Lesion ◽

S 100 ◽

Colon And Rectum

Abstract Background：Mucosal Schwann cell hamartoma (MSCH) is a newly recognized neural lesion of the gastrointestinal (GI) tract. MSCHs are mostly solitary and occur in the colon and rectum. We present a case with multiple MSCHs arising in gastric antrum.Case presentation：A 49-year-old woman with atrophic gastritis was accidentally found to have multiple mucosal protrusion lesions in the gastric antrum during endoscopic follow-up. Biopsy specimens revealed a spindle cell lesion in the lamina propria with positive reaction to the S-100 and SOX-10 protein. The final diagnosis was MSCH.Conclusions: MSCH is a benign mucosal spindle cell lesion of the GI tract and does not associate with inherited syndromes. It is most commonly seen in the colorectum, but can also be found in stomach and gallbladder. In this case, MSCH occurred in gastric antrum with multiple lesions. MSCH is benign lesion and successive treatment, work-up and follow-up are unnecessary.

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