scholarly journals Gastric Carcinoma with Osteoclast-Like Giant Cells Coexisting with Gastrointestinal Spindle Cell Tumor

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Christos Poulios ◽  
Triantafyllia Koletsa ◽  
Antonis Goulas ◽  
Georgia Karayannopoulou ◽  
Eleni Vrettou ◽  
...  
Keyword(s):  
Gastric Adenocarcinoma ◽  
Spindle Cell ◽  
Gastroesophageal Junction ◽  
Subtotal Gastrectomy ◽  
Giant Cells ◽  
Gastric Fundus ◽  
Gastric Carcinomas ◽  
Spindle Cell Lesion ◽  
Exophytic Tumor ◽  
Upper Abdominal

Reactive multinucleated osteoclast-like giant cells (OGCs) have been described in a variety of neoplasms but rarely in gastric carcinomas. Reported herein is a case of an 81-year-old Caucasian male presented with upper abdominal pain and dysphagia. Esophagogastroscopy revealed an ulcerative mass and a specimen of subtotal gastrectomy and lower esophagectomy was sent for histologic examination. At the gastroesophageal junction an exophytic tumor, measured 2.2 cm in greatest diameter, was observed. Sections from the tumor showed gastric adenocarcinoma, stage pT1bpN0. Diffusely among the neoplastic cells multinucleated giant cells, resembling osteoclasts, were observed, which were positive for CD68, lysozyme, and vimentin and negative for AE1/AE3, CK8/18, hHCG, and LMP1. Moreover, in a random section from the gastric fundus, a spindle cell lesion, sized 0.6 cm, was revealed, which was positive for CD117 and CD34 antigens and was diagnosed as gastrointestinal stromal tumor (GIST). The presence of OGCs is an uncommon finding in gastric carcinomas and by analogy to breast and pancreatic carcinomas it could characterize a rare distinct morphological variant of gastric adenocarcinoma. Due to the limited number of the reported cases, the prognostic value of OGCs is under discussion. Furthermore, pathologists should be aware that incidental GIST may accompany any tumor.

Sarcomatoid Carcinoma of the Small Intestine: A Case Report and Review of the Literature

2004 ◽  
Vol 128 (8) ◽  
pp. 918-921
Author(s):  
Michelle Reid-Nicholson ◽  
Muhammed Idrees ◽  
Giorgio Perino ◽  
Prodromos Hytiroglou
Keyword(s):  
Small Bowel ◽  
Epithelial Membrane Antigen ◽  
Spindle Cell ◽  
English Literature ◽  
Sarcomatoid Carcinoma ◽  
Giant Cells ◽  
Intestinal Wall ◽  
Cytokeratin 20 ◽  
Spindle Cells ◽  
Immunohistochemical Stains

Abstract Sarcomatoid carcinoma of the small bowel is rare; to our knowledge, 19 cases have been reported to date in the English literature under several names. We report an additional case occurring in the jejunum of a 55-year-old man. The tumor was a polypoid 7.5-cm mass, which infiltrated the full thickness of the intestinal wall and the serosa of an adhesed loop of small bowel. On microscopic examination, the neoplasm was composed of sheets of spindle cells; focally, an anaplastic component was present, including tumor giant cells with bizarre nuclei. On immunohistochemical stains, tumor cells were positive for cytokeratin 7, cytokeratin AE1/AE3, vimentin, and focally, epithelial membrane antigen. No staining for cytokeratin 20 was found. Sarcomatoid carcinoma must be kept in mind in the differential diagnosis of malignant spindle cell tumors of the small bowel. As consensus regarding the terminology of these rare tumors is being reached, immunohistochemical stains are essential for accurate diagnosis.

scholarly journals Histological and Ultrastructural Description of Benign Adipocytic Tumors in Farmed Striped Sea Bream (Lythognathus mormyrus)

Animals ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 3413
Author(s):  
Massimo Orioles ◽  
Marco Galeotti ◽  
Pierpaolo Patarnello ◽  
Stefano Pizzolitto ◽  
Donatella Volpatti
Keyword(s):  
Spindle Cell ◽  
Giant Cells ◽  
Collagen Fibers ◽  
Sea Bream ◽  
Spindle Cell Lipoma ◽  
Marine Aquaculture ◽  
Spindle Cells ◽  
Adipocytic Tumors ◽  
Abundant Cytoplasm ◽  
The Masses

Cutaneous neoplasms affecting wild striped bream (Lythognathus mormyrus) have been recorded after their introduction in a marine aquaculture farm in the Adriatic Sea. The tumors were evident on 24% of the reared fish, showing single or multiple nodules, with a diameter ranging between 0.5–4.0 cm. Histologically, all the neoplastic lesions were located in the stratum spongiosum of the dermis and were surrounded by a thin capsule of connective tissue. The tumors were predominantly composed of adipocytes grouped and surrounded by a thin net of fibroblasts and collagen fibers. In some lipomas a mixture of adipocytes and uniform spindle cells were also observed. Fibroblasts and collagen fibers, or spindle cells, showing few mitotic figures were mainly observed in other nodules. Three of the tumors showed bands of cells with elongated nuclei. Five neoplasms differed from the classic spindle cell lipoma due to the presence of scattered giant cells. These cells presented acidophilic abundant cytoplasm with multiple hyperchromatic nuclei showing a concentric “floret-like” arrangement. The tumors were further characterized by ultrastructural observations that allowed ruling out the presence of virus-like particles within the lesions. Histological features of the masses lead to the identification of four prevalent patterns of neoplasms: lipoma, fibrolipoma, spindle cell lipoma (SCL), and atypical spindle cell-like lipoma (ASCL). The different neoplasms could arise from the transformation of mesenchymal cells of dermal origin. To the author’s knowledge, this is the first report describing key differential histological and ultrastructural features of these neoplasms in striped sea bream.

scholarly journals Meatal ulcer: very rare complication of Foley catheterization

2017 ◽  
Vol 4 (4) ◽  
pp. 1505
Author(s):  
Vipul D. Yagnik
Keyword(s):  
Rare Complication ◽  
Subtotal Gastrectomy ◽  
Blood Chemistry ◽  
Stomach Wall ◽  
Aseptic Technique ◽  
Urethral Catheterization ◽  
Exophytic Tumor ◽  
Surgical History ◽  
Trained Staff

A 65 year old gentleman was admitted with the diagnosis of exophytic tumor arising from the stomach wall. His vitals were normal. Patient was poorly built and poorly nourished with BMI of blood chemistry, ECG, and ECHO was normal. His past medical and surgical history was not significant. Urethral catheterization was performed pre-operative with strict aseptic technique. Patient underwent   laparotomy with subtotal gastrectomy and gastrojejunostomy. Catheter care was done regularly by trained staff. Catheter was removed on third post operative day. After removal of catheter, Patient had a difficulty in passing   urine. On examination, single meatal ulcer was noted (Figure 1). Post –operative course was unremarkable. Patient is in follow up since last six month without any problem.

Pressure Characteristics of the Esophagus and Its Sphincters in Dogs

1958 ◽  
Vol 193 (1) ◽  
pp. 9-14 ◽  
Author(s):  
Jerry F. Schlegel ◽  
Charles F. Code
Keyword(s):  
Gastroesophageal Junction ◽  
Elevated Pressure ◽  
Gastric Fundus ◽  
Peristaltic Wave ◽  
Human Beings ◽  
Healthy Human ◽  
Pressure Transducers ◽  
Small Water ◽  
Healthy Dogs ◽  
The Mean

The pressure in the esophagus and its sphincters in seven well-trained, intact, healthy dogs was studied using three small water-filled polyethylene tubes attached to pressure transducers. To obtain resting pressures these tubes were withdrawn at intervals of 0.5–2.0 cm through the gastroesophageal junction, the esophagus and the pharyngoesophageal junction. Swallowing was induced by injection of water into the mouth or pharynx of the animals, and responses were recorded from selected sites. At rest, bands of elevated pressure about 2 cm wide were detected at the pharyngoesophageal and gastroesophageal junctions. The mean maximal pressures in the two zones were 20 and 6.9 cm of water, respectively. Pressure in the esophagus at rest was less than that in the gastric fundus. When swallowing began, the elevated pressure in the junctional zones decreased promptly, rose to high values as the peristaltic wave of deglutition swept into them, and then declined to resting levels. A peristaltic wave of high pressure swept through the esophagus with each swallow. These findings indicate that the junctional zones act as sphincters. Their behavior is identical to that in healthy human beings. The pressure pattern in the esophagus itself with swallowing is also the same in the two species, but in the dog the peristaltic wave moves faster and the rise of pressure is briefer. These differences may reflect the fact that the muscle of the dog's esophagus is entirely skeletal.

Malignant meningioma of the oculomotor nerve without dural attachment

1998 ◽  
Vol 88 (6) ◽  
pp. 1104-1106 ◽  
Author(s):  
Alister J. Hart ◽  
James Allibone ◽  
Adrian T. H. Casey ◽  
David G. T. Thomas
Keyword(s):  
Spindle Cell ◽  
Oculomotor Nerve ◽  
Histological Investigation ◽  
Malignant Meningioma ◽  
Resonance Imaging ◽  
Content Type ◽  
Spindle Cell Lesion ◽  
History Of ◽  
Dural Attachment ◽  
Fine Print

✓ Meningiomas, thought to arise from arachnoid cap cells, are usually attached to the dura. Malignancy is present in approximately 1% of these tumors. The authors report the case of a patient with a malignant meningioma arising from the oculomotor nerve with no dural attachment. The patient presented with a 7-month history of left-sided ptosis and diplopia. Magnetic resonance imaging demonstrated an extrinsic mass compressing the root of the oculomotor nerve at its exit from the midbrain. During surgery, a left-sided subtemporal approach revealed the tumor to be arising from the oculomotor nerve. Histological investigation showed a malignant spindle cell lesion with an immunohistochemical profile that was consistent with malignant meningioma. To the authors' knowledge, this is the first documented case of a malignant meningioma arising from the oculomotor nerve.

Seventh edition (2010) of gastric adenocarcinoma AJCC staging system: Is there room for improvement?

2012 ◽  
Vol 30 (4_suppl) ◽  
pp. 77-77
Author(s):  
Manali I. Patel ◽  
Kim F Rhoads ◽  
Yifei Ma ◽  
James M. Ford ◽  
Jeffrey A. Norton ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gastric Adenocarcinoma ◽  
Health Planning ◽  
Gastroesophageal Junction ◽  
Staging System ◽  
Rank Test ◽  
Population Database ◽  
Curative Intent ◽  
Ajcc Staging System ◽  
Ajcc Staging

77 Background: The gastric cancer AJCC staging system recently underwent significant modifications of the T and N categories as well as stage groupings. The new system has not been validated on a US population database, but studies on Asian patients have reported no difference in survival between stages IB and IIA, as well as IIB and IIIA. Methods: California Cancer Registry data linked to Office of Statewide Health Planning and Development discharge abstracts were used to identify patients with gastric adenocarcinoma (gastroesophageal junction tumors excluded) who underwent curative-intent surgical resection from 2002 to 2006. AJCC stage was reclassified based on the 7th edition. Disease-specific survival (DSS) probabilities were calculated using the Kaplan-Meier method and compared using the log rank test. Results: Of 4,985 patients identified, 2,262 had complete pathologic data and known cause of death. Median age was 70 years and 60% were males. Median number of examined lymph nodes was 12 and 39% of patients received adjuvant chemotherapy. The 7th edition AJCC system did not distinguish outcome adequately between stages IB and IIA (P = .25), or IIB and IIIA (P = .33, Table ). By merging stage II into one category and moving T2N1 to stage IB and T2N2, T1N3 to stage IIIA, we propose a new grouping system which showed improved discriminatory ability ( Table ). Conclusions: In this first study validating the new 7th edition AJCC staging system for gastric cancer on a US population, we found stages IB and IIA, as well as IIB and IIIA to perform similarly. We propose a revised stage grouping for the AJCC system that better discriminates between outcomes. [Table: see text]

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