scholarly journals Metastatic thymoma – A rare presentation as a dural-based spindle cell lesion in the cranial cavity

Pathology ◽  
2016 ◽  
Vol 48 ◽  
pp. S65
Author(s):  
Manish Mahadeorao Bundele ◽  
Lee Hwei Yee
Keyword(s):  
Spindle Cell ◽  
Cranial Cavity ◽  
Rare Presentation ◽  
Spindle Cell Lesion

scholarly journals Multiple Spindle Cell Lipomas of Tongue in 7-Year-Old Child: A Rare Presentation

OTO Open ◽  
2021 ◽  
Vol 5 (4) ◽  
pp. 2473974X2110614
Author(s):  
Sonika Dhari Shrestha ◽  
Uma Bhatta ◽  
Anuj Kayastha ◽  
Tridip Bahadur Pantha
Keyword(s):  
Spindle Cell ◽  
Rare Presentation ◽  
Multiple Spindle

Pancreatic Carcinosarcoma with a Rare Presentation

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S65-S66
Author(s):  
J Khan ◽  
S Guo
Keyword(s):  
Spindle Cell ◽  
Sarcomatoid Carcinoma ◽  
World Health ◽  
Rare Entity ◽  
Cell Component ◽  
Rare Presentation ◽  
Term Survival ◽  
Cytoplasmic Staining ◽  
Spindle Cell Component ◽  
Head Of The Pancreas

Abstract Introduction/Objective Carcino-sarcoma of the pancreas is a rare tumor and very limited clinical and pathologic data have been reported in the literature. As per World Health Organization (WHO) classification of tumors of the digestive system, the carcinosarcoma of the pancreas is classified together with sarcomatoid carcinoma and anaplastic giant cell carcinomas in undifferentiated carcinoma of pancreas. Carcinosarcoma is a rare entity with very poor prognosis. Methods/Case Report Here we report a rare case of pancreatic carcinosarcoma in a 68 year old male patient who underwent a pancreatoduodenectomy for unilocular cystic mass in the head of the pancreas. The mass grossly replaces the whole head of the pancreas. Histologically, the lesion showed a high-grade spindle cell component and adjacent moderately differentiated adenocarcinoma. On immunohistochemical examination, the carcinomatous component was positive for epithelial markers, and the sarcomatous component was positive for DOG1 and had a focal cytoplasmic staining for S-100. The diagnosis of pancreatic carcinosarcoma was rendered. Treatment options are same as of pancreatic carcinoma. Surgical resection is the best option available for patients. Systemic chemotherapy is indicated for patients with distant metastasis or patients with other contraindications. Despite surgery and adjuvant chemotherapy, recurrence rates are high, and prognosis is poor. However, there are no relevant standard chemotherapies available. Based on the limited number of reported cases, the prognosis of carcinosarcoma of the pancreas appears to be poor. But some cases with long term survival have been reported. There are very few primary pancreatic neoplasms with carcinomatous and sarcomatous components reported in the current literature. Results (if a Case Study enter NA) NA Conclusion This case highlights the importance of familiarity with histopathology of this rare entity, and to order proper immunohistochemical and molecular work-up when there is a suspicious abnormal spindle cell component.

scholarly journals Gastric Carcinoma with Osteoclast-Like Giant Cells Coexisting with Gastrointestinal Spindle Cell Tumor

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Christos Poulios ◽  
Triantafyllia Koletsa ◽  
Antonis Goulas ◽  
Georgia Karayannopoulou ◽  
Eleni Vrettou ◽  
...  
Keyword(s):  
Gastric Adenocarcinoma ◽  
Spindle Cell ◽  
Gastroesophageal Junction ◽  
Subtotal Gastrectomy ◽  
Giant Cells ◽  
Gastric Fundus ◽  
Gastric Carcinomas ◽  
Spindle Cell Lesion ◽  
Exophytic Tumor ◽  
Upper Abdominal

Reactive multinucleated osteoclast-like giant cells (OGCs) have been described in a variety of neoplasms but rarely in gastric carcinomas. Reported herein is a case of an 81-year-old Caucasian male presented with upper abdominal pain and dysphagia. Esophagogastroscopy revealed an ulcerative mass and a specimen of subtotal gastrectomy and lower esophagectomy was sent for histologic examination. At the gastroesophageal junction an exophytic tumor, measured 2.2 cm in greatest diameter, was observed. Sections from the tumor showed gastric adenocarcinoma, stage pT1bpN0. Diffusely among the neoplastic cells multinucleated giant cells, resembling osteoclasts, were observed, which were positive for CD68, lysozyme, and vimentin and negative for AE1/AE3, CK8/18, hHCG, and LMP1. Moreover, in a random section from the gastric fundus, a spindle cell lesion, sized 0.6 cm, was revealed, which was positive for CD117 and CD34 antigens and was diagnosed as gastrointestinal stromal tumor (GIST). The presence of OGCs is an uncommon finding in gastric carcinomas and by analogy to breast and pancreatic carcinomas it could characterize a rare distinct morphological variant of gastric adenocarcinoma. Due to the limited number of the reported cases, the prognostic value of OGCs is under discussion. Furthermore, pathologists should be aware that incidental GIST may accompany any tumor.

Malignant meningioma of the oculomotor nerve without dural attachment

1998 ◽  
Vol 88 (6) ◽  
pp. 1104-1106 ◽  
Author(s):  
Alister J. Hart ◽  
James Allibone ◽  
Adrian T. H. Casey ◽  
David G. T. Thomas
Keyword(s):  
Spindle Cell ◽  
Oculomotor Nerve ◽  
Histological Investigation ◽  
Malignant Meningioma ◽  
Resonance Imaging ◽  
Content Type ◽  
Spindle Cell Lesion ◽  
History Of ◽  
Dural Attachment ◽  
Fine Print

✓ Meningiomas, thought to arise from arachnoid cap cells, are usually attached to the dura. Malignancy is present in approximately 1% of these tumors. The authors report the case of a patient with a malignant meningioma arising from the oculomotor nerve with no dural attachment. The patient presented with a 7-month history of left-sided ptosis and diplopia. Magnetic resonance imaging demonstrated an extrinsic mass compressing the root of the oculomotor nerve at its exit from the midbrain. During surgery, a left-sided subtemporal approach revealed the tumor to be arising from the oculomotor nerve. Histological investigation showed a malignant spindle cell lesion with an immunohistochemical profile that was consistent with malignant meningioma. To the authors' knowledge, this is the first documented case of a malignant meningioma arising from the oculomotor nerve.

scholarly journals Left Supraclavicular Spindle Cell Lipoma

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Oladejo Olaleye ◽  
Bertram Fu ◽  
Ram Moorthy ◽  
Charles Lawson ◽  
Myles Black ◽  
...  
Keyword(s):  
Spindle Cell ◽  
Excisional Biopsy ◽  
Neurological Deficits ◽  
Excision Biopsy ◽  
Low Grade ◽  
Spindle Cell Lipoma ◽  
Rare Presentation ◽  
Spindle Cells ◽  
Immuno Histochemistry ◽  
Rare Benign Tumour

Background. Spindle cell lipoma (SCL) is a benign lipomatous tumour, typically occurring in the posterior neck, shoulder or upper back of elderly males. They compose of fat, CD34 positive spindle cells, and ropey collagen on a myxoid matrix. This case highlights a rare presentation of SCL and the need for pre-operative diagnosis.Case Report. A 63-year-old gentleman presented with a pre-existing left supraclavicular mass that had recently increased in size. FNA and CT Scans were performed and results discussed in the mutidisciplinary team meeting. Excisional biopsy was recommended.Radiology. CT neck showed a left supraclavicular mass of fatty density with fine internal septations. A low-grade liposarcoma could not be excluded.Histopathology. FNA was indeterminate. Histology of specimen showed bland spindle cells with no evidence of malignancy. Immuno-histochemistry showed SCL with CD34 positivity and negative staining on CDK4 and p16.Management. Excision biopsy of the mass was performed which was technically difficult as the mass invaginated around the brachial plexus. The patient recovered well post-operatively with no neurological deficits.Conclusion. Spindle cell lipoma is a rare benign tumour and a pre-operative diagnosis based on the clinical context, imaging and immuno-histochemistry is crucial to management.

Anal spindle cell lesion

2009 ◽  
Vol 15 (1) ◽  
pp. 51-54 ◽  
Author(s):  
Charanjit Kaur ◽  
Caroline Finlayson
Keyword(s):  
Spindle Cell ◽  
Spindle Cell Lesion

scholarly journals HER2-Positive Metaplastic Spindle Cell Carcinoma Associated with Synchronous Bilateral Apocrine Carcinoma of the Breast

2014 ◽  
Vol 2014 ◽  
pp. 1-5
Author(s):  
Katsumi Kito ◽  
Toshiharu Maeda ◽  
Keiko Ninomiya ◽  
Atsuro Sugita ◽  
Teiri Sagawa ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Spindle Cell ◽  
Spindle Cell Carcinoma ◽  
Metaplastic Carcinoma ◽  
Apocrine Carcinoma ◽  
Her2 Positive ◽  
First Case ◽  
Spindle Cell Lesion ◽  
Apocrine Differentiation ◽  
The Right

Apocrine carcinoma, which is strictly defined as over 90% of tumor cells showing apocrine differentiation, is a rare variant of breast cancer. Here we report an uncommon case in which apocrine carcinomas developed concurrently in both breasts; in addition, a sarcomatoid spindle cell lesion was coincident in the right breast. Both apocrine carcinomas were immunohistochemically negative for estrogen receptor (ER) and progesterone receptor (PgR), but diffusely positive for androgen receptor (AR), GCDFP-15, and HER2. The presence of intraductal components in bilateral carcinomas and the absence of lymph node metastasis suggested that they were more likely to be individual primary lesions rather than metastatic disease. The spindle cell lesion showed a relatively well-circumscribed nodule contiguous with the apocrine carcinoma. HER2 oncoprotein overexpression was observed not only in the apocrine carcinoma, but also in the spindle cell lesion. Since the spindle cell component was intimately admixed with apocrine carcinoma and had focal cytokeratin expression, we diagnosed it as metaplastic spindle cell carcinoma, which was originated from the apocrine carcinoma. To our knowledge, this is the first case report of a patient with synchronous bilateral apocrine carcinomas coinciding with metaplastic carcinoma.

scholarly journals Spindle Cell Lipoma of Scrotum

2019 ◽  
Vol 2 (2) ◽  
pp. e40-e41
Author(s):  
Muhammad Iqbal ◽  
Sanjay Agarwal ◽  
Iqbal S. Shergill
Keyword(s):  
Male Patient ◽  
Spindle Cell ◽  
Benign Lesion ◽  
Histopathological Diagnosis ◽  
Spindle Cell Lipoma ◽  
Rare Presentation ◽  
Left Half

Spindle cell lipoma (SCL) in the scrotum is a very rare presentation with only a few cases reported in the literature. The most common sites for this benign lesion are the neck, shoulder, and back. We present a 72-year-old male patient with painless swelling on the left half of the scrotum with a histopathological diagnosis of SCL.

scholarly journals Nodular Fasciitis of the breast – An uncommon benign reactive proliferative lesion

2021 ◽  
Vol 6 (4) ◽  
pp. 291-294
Author(s):  
Sunil V Jagtap ◽  
Vaidehi Nagar ◽  
S J Bhosale ◽  
Dharmesh Nagar ◽  
Swati S Jagtap
Keyword(s):  
Rare Case ◽  
Spindle Cell ◽  
Left Breast ◽  
Breast Mass ◽  
Nodular Fasciitis ◽  
Breast Masses ◽  
Surgical Department ◽  
Irregular Margin ◽  
Spindle Cell Lesion ◽  
Proliferative Lesion

Nodular fasciitis is rarely reported in breast. It is benign reactive proliferative lesion of fibroblast. A 65 year old female presented to surgical department for left breast mass since 2 months duration, rapidly enlarging without any regional lymphadenopathy. Mammography showed hyperdensity masses with irregular margin. On FNAC reported as benign spindle cell lesion. Left sided two breast masses measuring 4 x 3.3 x 2.5cm and 2.0 x 1.6 x 0.5cm were excised and on histopathology reported as Nodular Fasciitis of left breast. We are presenting this extremely rare case of nodular fasciitis of breast for its clinical, radiological and histopathological findings.

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