Can serum glial fibrillary acidic protein (GFAP) solve the longstanding problem of diagnoses and monitoring progressive multiple sclerosis?

2021 ◽  
pp. 102931
Author(s):  
Kira Groen ◽  
Jeannette Lechner-Scott ◽  
Daniela Pohl ◽  
Michael Levy ◽  
Gavin Giovannoni ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Glial Fibrillary Acidic Protein ◽  
Progressive Multiple Sclerosis ◽  
Acidic Protein

A role for hypertrophic astrocytes and astrocyte precursors in a case of rapidly progressive multiple sclerosis

2003 ◽  
Vol 9 (4) ◽  
pp. 332-341 ◽  
Author(s):  
Yvette Morcos ◽  
Sang Min Lee ◽  
Michael C Levin
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Glial Fibrillary Acidic Protein ◽  
Glial Cells ◽  
Critical Role ◽  
Progressive Multiple Sclerosis ◽  
Acidic Protein ◽  
Cellular Internalization ◽  
Normal Appearing White Matter

The purpose of this study was to examine the roles played by astrocytes in a case of rapidly progressive multiple sclerosis (MS). Within early-active and active lesions, hypertrophic astrocytes played an important role in lesion patho logy through the phagocytosis of myelin and axonal debris and through the internalization of other glial cells, including astrocytes. In addition to this critical role, hypertrophic astrocytes, in areas that lack significant inflammation (within the adjacent normal appearing white matter and within late remyelinating lesions) were found to be active in myelin and axonal debris phagocytosis with no evidence of cellular internalization. Hypertrophic astrocytes therefore not only play an important role in the patho genesis of MS lesions but also exert a continued deleterio us effect upon tissue in the absence of significant inflammation. In addition, we found evidence for a significant population of vimentin-positive, glial fibrillary acidic protein (GFA P)-negative, bipolar, astrocyte precursors within the late remyelinating lesions. Their significance is not known but a possible role may include their participatio n in the successful remyelination of the lesion.

Serum glial fibrillary acidic protein correlates with multiple sclerosis disease severity

2018 ◽  
Vol 26 (2) ◽  
pp. 210-219 ◽  
Author(s):  
Heidi Högel ◽  
Eero Rissanen ◽  
Christian Barro ◽  
Markus Matilainen ◽  
Marjo Nylund ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Nervous System ◽  
Glial Fibrillary Acidic Protein ◽  
Disease Progression ◽  
Disease Severity ◽  
Single Molecule ◽  
Progressive Disease ◽  
Disease Duration ◽  
Acidic Protein ◽  
Csf Levels

Background: Cerebrospinal fluid (CSF) levels of two soluble biomarkers, glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL), have been shown to associate with multiple sclerosis (MS) disease progression. Now, both biomarkers can be detected reliably in serum, and importantly, their serum levels correlate well with their CSF levels. Objective: To evaluate the usability of serum GFAP measurement as a biomarker of progressive disease and disease severity in MS. Methods: Clinical course, Expanded Disability Status Scale (EDSS), disease duration, patient age and magnetic resonance imaging (MRI) parameters were reviewed in 79 MS patients in this cross-sectional hospital-based study. Serum samples were collected for measurement of GFAP and NfL concentrations using single molecule array (Simoa) assay. A cohort of healthy controls was evaluated for comparison. Results: Higher serum concentrations of both GFAP and NfL were associated with higher EDSS, older age, longer disease duration, progressive disease course and MRI pathology. Conclusion: Earlier studies have demonstrated that GFAP, unlike NfL, is not increased in association with acute focal inflammation-related nervous system damage. Our work suggests that GFAP serum level associates with disease progression in MS and could potentially serve as an easily measurable biomarker of central nervous system (CNS) pathology related to disease progression in MS.

Glial fibrillary acidic protein: a potential biomarker for progression in multiple sclerosis

2011 ◽  
Vol 258 (5) ◽  
pp. 882-888 ◽  
Author(s):  
M. Axelsson ◽  
C. Malmeström ◽  
S. Nilsson ◽  
S. Haghighi ◽  
L. Rosengren ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Glial Fibrillary Acidic Protein ◽  
Protein A ◽  
Acidic Protein ◽  
Potential Biomarker

Neurofilament and glial fibrillary acidic protein in multiple sclerosis

Neurology ◽  
2004 ◽  
Vol 63 (9) ◽  
pp. 1586-1590 ◽  
Author(s):  
N. Norgren ◽  
P. Sundstrom ◽  
A. Svenningsson ◽  
L. Rosengren ◽  
T. Stigbrand ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Glial Fibrillary Acidic Protein ◽  
Acidic Protein

Long-term cultured astrocytes inhibit myelin formation, but not axonal growth in the co-cultured nerve tissue

1996 ◽  
Vol 2 (2) ◽  
pp. 91-95 ◽  
Author(s):  
Mikio Ishikawa ◽  
Tetsuro Tsukamoto ◽  
Teiji Yamamoto
Keyword(s):  
Multiple Sclerosis ◽  
Glial Fibrillary Acidic Protein ◽  
Myelin Sheath ◽  
Axonal Growth ◽  
Acidic Protein ◽  
Nerve Tissue ◽  
Myelin Formation ◽  
Cultured Astrocytes ◽  
Cerebellar Tissue

The chronic demyelinated plaque of multiple sclerosis (MS) is characterised by a loss of oligodendrocytes, astrogliosis, and incomplete or no remyelination which probably results in part from the suppressive effects of gliotic astrocytes on myelin formation. We explanted mouse cerebella on astrocyte cultures which had been maintained for 2 to 12 weeks and assessed the myelination in the cerebellar tissue at 18 days after explanation. Myelination occurred vigorously in the tissue explanted on 2-to 4-week-old astrocytes, but was poorer in the tissue explanted on astrocytes older than 4 weeks. No myelin sheath was formed on 12-week-old astrocytes, although axons developed equally as well as those in the tissues explanted on 2-week-old astrocytes. As astrocytes were maintained longer, they became fibrous and immunostained more deeply with anti-glial fibrillary acidic protein antibody, being analogous to astrogliosis. These findings imply that astrogliosis in chronic demyelinated lesions of MS may potentially block remyelination.

scholarly journals Increased serum glial fibrillary acidic protein associates with microstructural white matter damage in multiple sclerosis

2021 ◽  
Vol 50 ◽  
pp. 102810 ◽  
Author(s):  
Maija Saraste ◽  
Svetlana Bezukladova ◽  
Markus Matilainen ◽  
Marcus Sucksdorff ◽  
Jens Kuhle ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Glial Fibrillary Acidic Protein ◽  
Acidic Protein ◽  
White Matter Damage
Sign in / Sign up

Export Citation Format

Share Document