Use of a fluorescent probe to monitor the enhanced affinity of rh-BMP-2 to silicated-calcium phosphate synthetic bone graft substitutes under competitive conditions

The purpose of this review was to compare the efficacy and safety of synthetic bone graft substitutes versus autograft or allograft for the treatment of lumbar and cervical spinal degenerative diseases. Multiple major medical reference databases were searched for studies that evaluated spinal fusion using synthetic bone graft substitutes (either alone or with an autograft or allograft) compared with autograft and allograft. Randomized controlled trials (RCT) and cohort studies with more than 10 patients were included. Radiographic fusion, patient-reported outcomes, and functional outcomes were the primary outcomes of interest. The search yielded 214 citations with 27 studies that met the inclusion criteria. For the patients with lumbar spinal degenerative disease, data from 19 comparative studies were included: 3 RCTs, 12 prospective, and 4 retrospective studies. Hydroxyapatite (HA), HA+collagen, β-tricalcium phosphate (β-TCP), calcium sulfate, or polymethylmethacrylate (PMMA) were used. Overall, there were no differences between the treatment groups in terms of fusion, functional outcomes, or complications, except in 1 study that found higher rates of HA graft absorption. For the patients with cervical degenerative conditions, data from 8 comparative studies were included: 4 RCTs and 4 cohort studies (1 prospective and 3 retrospective studies). Synthetic grafts included HA, β-TCP/HA, PMMA, and biocompatible osteoconductive polymer (BOP). The PMMA and BOP grafts led to lower fusion rates, and PMMA, HA, and BOP had greater risks of graft fragmentation, settling, and instrumentation problems compared with iliac crest bone graft. The overall quality of evidence evaluating the potential use and superiority of the synthetic biological materials for lumbar and cervical fusion in this systematic review was low or insufficient, largely due to the high potential for bias and small sample sizes. Thus, definitive conclusions or recommendations regarding the use of these synthetic materials should be made cautiously and within the context of the limitations of the evidence.

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Microporosity enhances bioactivity of synthetic bone graft substitutes

Journal of Materials Science Materials in Medicine ◽

10.1007/s10856-005-6988-1 ◽

2005 ◽

Vol 16 (5) ◽

pp. 467-475 ◽

Cited By ~ 204

Author(s):

K. A. Hing ◽

B. Annaz ◽

S. Saeed ◽

P. A. Revell ◽

T. Buckland

Keyword(s):

Bone Graft ◽

Synthetic Bone ◽

Synthetic Bone Graft ◽

Bone Graft Substitutes

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Synthetic Bone Graft Substitutes

Otolaryngologic Clinics of North America ◽

10.1016/s0030-6665(20)30622-8 ◽

1994 ◽

Vol 27 (5) ◽

pp. 1037-1074 ◽

Cited By ~ 33

Author(s):

Peter D. Costantino ◽

Craig D. Friedman

Keyword(s):

Bone Graft ◽

Synthetic Bone ◽

Synthetic Bone Graft ◽

Bone Graft Substitutes

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In Vitro Elution Characteristics of Gentamicin and Vancomycin from Synthetic Bone Graft Substitutes

The Open Orthopaedics Journal ◽

10.2174/1874325001307010624 ◽

2013 ◽

Vol 7 (1) ◽

pp. 624-629 ◽

Cited By ~ 5

Author(s):

Gerrit Steffen Maier ◽

Klaus Edgar Roth ◽

Stefan Andereya ◽

Klaus Birnbaum ◽

Christopher Niedhart ◽

...

Keyword(s):

Bone Graft ◽

Bone Disease ◽

Detection Threshold ◽

Vancomycin Concentration ◽

Synthetic Bone ◽

Synthetic Bone Graft ◽

Homogeneous Particle ◽

Bone Graft Substitutes ◽

New Treatment

Objects: Beta tricalciumphosphate pellets loaded with individualized antibiotics may represent novel options in the treatment of osteomyelitis and infectious bone disease. Here, the in vitro antibiotic elution of vancomycin and gentamicin from the synthetic bone graft substitutes Cerasorb® and Cerasorb M® was tested. Methods: Antibiotic elution and concentration of gentamcin and vancomycin were measured using photometrically-based measurement and homogeneous particle-enhanced turbidimetric inhibition immunoassays (PETINIA). Results: Initially both materials showed a high release of the loaded antibiotics, with Cerasorb M® showing lower release levels for gentamicin and vancomycin than Cerasorb®. Gentamicin concentrations of Cerasorb M granules and Cerasorb were below the minimum detectiontreshold until day four and six of the experiment respectively. The vancomycin release-level followed a similar pattern, although the vancomycin concentration eluted by Cerasorb M® granules stayed above the detection threshold during the experimental time. Conclusions: Cerasorb® and Cersorb M® may represent a new treatment option in osteomyelitis and infectious bone disease.

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Synthetic bone graft substitutes

ANZ Journal of Surgery ◽

10.1046/j.1440-1622.2001.2128.x ◽

2001 ◽

Vol 71 (6) ◽

pp. 354-361 ◽

Cited By ~ 10

Author(s):

William R. Moore ◽

Stephen E. Graves ◽

Gregory I. Bain

Keyword(s):

Bone Graft ◽

Synthetic Bone ◽

Synthetic Bone Graft ◽

Bone Graft Substitutes

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Synthetic Bone Graft Substitutes: Basic Information for Successful Clinical Use

Bone Graft Substitutes and Bone Regenerative Engineering, 2nd Edition ◽

10.1520/mono62014000510 ◽

2014 ◽

pp. 219-250

Author(s):

Barbara D. Boyan ◽

David J. Cohen ◽

Zvi Schwartz

Keyword(s):

Bone Graft ◽

Clinical Use ◽

Basic Information ◽

Synthetic Bone ◽

Synthetic Bone Graft ◽

Bone Graft Substitutes

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Evaluation of an increased strut porosity silicate-substituted calcium phosphate, SiCaP EP, as a synthetic bone graft substitute in spinal fusion surgery: a prospective, open-label study

European Spine Journal ◽

10.1007/s00586-019-05926-1 ◽

2019 ◽

Vol 28 (7) ◽

pp. 1733-1742 ◽

Cited By ~ 2

Author(s):

Ciaran Bolger ◽

Drew Jones ◽

Steven Czop

Keyword(s):

Calcium Phosphate ◽

Bone Graft ◽

Bone Graft Substitute ◽

Open Label ◽

Fusion Surgery ◽

Open Label Study ◽

Label Study ◽

Synthetic Bone ◽

Synthetic Bone Graft ◽

Spinal Fusion Surgery

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Chronology of the Radiographic Appearances of the Calcium Sulfate-Calcium Phosphate Synthetic Bone Graft Composite following Resection of Bone Tumors: A Follow-up Study of Postoperative Appearances

Canadian Association of Radiologists Journal ◽

10.1016/j.carj.2014.11.004 ◽

2016 ◽

Vol 67 (1) ◽

pp. 21-27 ◽

Cited By ~ 4

Author(s):

Victoria Tan ◽

Nathan Evaniew ◽

Karen Finlay ◽

Erik Jurriaans ◽

Michelle Ghert ◽

...

Keyword(s):

Calcium Phosphate ◽

Bone Graft ◽

Calcium Sulfate ◽

Bone Ingrowth ◽

Graft Material ◽

Synthetic Graft ◽

Synthetic Bone ◽

Synthetic Bone Graft ◽

Graft Resorption

Purpose The objective of the study was to characterize the radiographic appearance of graft resorption and new bone incorporation into a postresection defect of the calcium-sulfate calcium-phosphate synthetic bone graft composite following resection of benign bone tumours. Methods Twenty-five patients who underwent treatment with the CaSO4/CaPO4 synthetic graft following bone tumour resection were retrospectively identified from our oncology database. Postoperative radiographs were assessed for: 1) combined partial graft resorption and ingrowth at the graft site; 2) complete graft resorption with complete incorporation of new bone into the defect. After chronologically grouping radiographs, the volume of graft material used to fill bony defects, radiographic evidence of complications, and patterns of resorption were recorded. Results Partial resorption of graft material/partial ingrowth of new bone was seen in 21 patients at 2.5 months postoperatively. Complete resorption of graft with complete new bone incorporation at the graft site was seen in 94% of cases (15 of 16) by 10 months after surgery. Mean time to complete incorporation of new bone was 6.7 months. Time to resorption of the graft with new bone ingrowth was found to be related to the volume of graft used with smaller volumes showing earlier resorption. For all cases demonstrating resorption (21 of 21), the pattern observed was peripheral to central. Five patients developed complications, including tumour recurrence, cyst formation, and graft site infection. Conclusion Our study suggests a characteristic time and volume related radiographic pattern of resorption and new bone ingrowth with the CaSO4/CaPO4 synthetic graft. Findings that deviate from this pattern may represent complication and warrant additional follow-up.

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