scholarly journals In Vitro Elution Characteristics of Gentamicin and Vancomycin from Synthetic Bone Graft Substitutes

2013 ◽  
Vol 7 (1) ◽  
pp. 624-629 ◽  
Author(s):  
Gerrit Steffen Maier ◽  
Klaus Edgar Roth ◽  
Stefan Andereya ◽  
Klaus Birnbaum ◽  
Christopher Niedhart ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Disease ◽  
Detection Threshold ◽  
Vancomycin Concentration ◽  
Synthetic Bone ◽  
Synthetic Bone Graft ◽  
Homogeneous Particle ◽  
Bone Graft Substitutes ◽  
New Treatment

Objects: Beta tricalciumphosphate pellets loaded with individualized antibiotics may represent novel options in the treatment of osteomyelitis and infectious bone disease. Here, the in vitro antibiotic elution of vancomycin and gentamicin from the synthetic bone graft substitutes Cerasorb® and Cerasorb M® was tested. Methods: Antibiotic elution and concentration of gentamcin and vancomycin were measured using photometrically-based measurement and homogeneous particle-enhanced turbidimetric inhibition immunoassays (PETINIA). Results: Initially both materials showed a high release of the loaded antibiotics, with Cerasorb M® showing lower release levels for gentamicin and vancomycin than Cerasorb®. Gentamicin concentrations of Cerasorb M granules and Cerasorb were below the minimum detectiontreshold until day four and six of the experiment respectively. The vancomycin release-level followed a similar pattern, although the vancomycin concentration eluted by Cerasorb M® granules stayed above the detection threshold during the experimental time. Conclusions: Cerasorb® and Cersorb M® may represent a new treatment option in osteomyelitis and infectious bone disease.

The New Art of Bone Graft Substitute Design

2007 ◽  
Vol 330-332 ◽  
pp. 959-962
Author(s):  
Ernst Dieter Klinkenberg ◽  
Hans Georg Neumann ◽  
Ulrike Bulnheim ◽  
Joachim Rychly
Keyword(s):  
Bone Graft ◽  
Bone Graft Substitute ◽  
Graft Material ◽  
Synthetic Bone ◽  
Synthetic Bone Graft ◽  
Vital Cell ◽  
Design And Manufacturing ◽  
Bone Graft Substitutes ◽  
First Time

A new method of design and manufacturing of bone graft substitutes is introduced. For the first time it is possible to prepare bone graft substitutes with a directed and controlled pore structure. Furthermore, the formation of sophisticated geometries is feasible. First in vitro investigations with cell cultures show a vital cell growing on the synthetic bone graft material. Numerous applications are possible.

scholarly journals Synthetic bone graft versus autograft or allograft for spinal fusion: a systematic review

2016 ◽  
Vol 25 (4) ◽  
pp. 509-516 ◽  
Author(s):  
Zorica Buser ◽  
Darrel S. Brodke ◽  
Jim A. Youssef ◽  
Hans-Joerg Meisel ◽  
Sue Lynn Myhre ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cohort Studies ◽  
Bone Graft ◽  
Spinal Fusion ◽  
Comparative Studies ◽  
Functional Outcomes ◽  
Retrospective Studies ◽  
Synthetic Bone ◽  
Synthetic Bone Graft ◽  
Bone Graft Substitutes

The purpose of this review was to compare the efficacy and safety of synthetic bone graft substitutes versus autograft or allograft for the treatment of lumbar and cervical spinal degenerative diseases. Multiple major medical reference databases were searched for studies that evaluated spinal fusion using synthetic bone graft substitutes (either alone or with an autograft or allograft) compared with autograft and allograft. Randomized controlled trials (RCT) and cohort studies with more than 10 patients were included. Radiographic fusion, patient-reported outcomes, and functional outcomes were the primary outcomes of interest. The search yielded 214 citations with 27 studies that met the inclusion criteria. For the patients with lumbar spinal degenerative disease, data from 19 comparative studies were included: 3 RCTs, 12 prospective, and 4 retrospective studies. Hydroxyapatite (HA), HA+collagen, β-tricalcium phosphate (β-TCP), calcium sulfate, or polymethylmethacrylate (PMMA) were used. Overall, there were no differences between the treatment groups in terms of fusion, functional outcomes, or complications, except in 1 study that found higher rates of HA graft absorption. For the patients with cervical degenerative conditions, data from 8 comparative studies were included: 4 RCTs and 4 cohort studies (1 prospective and 3 retrospective studies). Synthetic grafts included HA, β-TCP/HA, PMMA, and biocompatible osteoconductive polymer (BOP). The PMMA and BOP grafts led to lower fusion rates, and PMMA, HA, and BOP had greater risks of graft fragmentation, settling, and instrumentation problems compared with iliac crest bone graft. The overall quality of evidence evaluating the potential use and superiority of the synthetic biological materials for lumbar and cervical fusion in this systematic review was low or insufficient, largely due to the high potential for bias and small sample sizes. Thus, definitive conclusions or recommendations regarding the use of these synthetic materials should be made cautiously and within the context of the limitations of the evidence.

Microporosity enhances bioactivity of synthetic bone graft substitutes

2005 ◽  
Vol 16 (5) ◽  
pp. 467-475 ◽  
Author(s):  
K. A. Hing ◽  
B. Annaz ◽  
S. Saeed ◽  
P. A. Revell ◽  
T. Buckland
Keyword(s):  
Bone Graft ◽  
Synthetic Bone ◽  
Synthetic Bone Graft ◽  
Bone Graft Substitutes

Synthetic Bone Graft Substitutes

1994 ◽  
Vol 27 (5) ◽  
pp. 1037-1074 ◽  
Author(s):  
Peter D. Costantino ◽  
Craig D. Friedman
Keyword(s):  
Bone Graft ◽  
Synthetic Bone ◽  
Synthetic Bone Graft ◽  
Bone Graft Substitutes

Synthetic bone graft substitutes

2001 ◽  
Vol 71 (6) ◽  
pp. 354-361 ◽  
Author(s):  
William R. Moore ◽  
Stephen E. Graves ◽  
Gregory I. Bain
Keyword(s):  
Bone Graft ◽  
Synthetic Bone ◽  
Synthetic Bone Graft ◽  
Bone Graft Substitutes

Bone Substitutes as a Drug Delivery of Antibiotics

2014 ◽  
Vol 631 ◽  
pp. 321-325
Author(s):  
Cornelia Ganz ◽  
Thomas Gerber
Keyword(s):  
Drug Delivery ◽  
Bone Disease ◽  
Detection System ◽  
Aminoglycoside Antibiotic ◽  
Bone Substitutes ◽  
Bone Graft Substitute ◽  
Antibiotic Concentration ◽  
Synthetic Bone ◽  
Synthetic Bone Graft

The aim of the present study was the in vitro investigation of a synthetic bone graft substitute loaded with individual antibiotics for the treatment of osteomyelitis and infectious bone disease. The elution of gentamicin, an aminoglycoside antibiotic, from the NanoBone® products NanoBone® S granules (NBG) and lyophilized NanoBone® (NBP) putty was tested over a period of one week. An indirect photometrically-based detection system was used to measure the released antibiotic concentration. Both materials showed very different release behaviour. After one day lyophilized NanoBone® putty delivered 100% of the gentamicin value, whereas NanoBone® S granules released one-fifth of the used gentamicin level.

In vitro stability of open wedge high tibial osteotomy with synthetic bone graft

The Knee ◽  
2010 ◽  
Vol 17 (3) ◽  
pp. 217-220 ◽  
Author(s):  
Ryohei Takeuchi ◽  
Haruhiko Bito ◽  
Yasushi Akamatsu ◽  
Toshihiko Shiraishi ◽  
Shin Morishita ◽  
...  
Keyword(s):  
Bone Graft ◽  
High Tibial Osteotomy ◽  
Tibial Osteotomy ◽  
Open Wedge ◽  
Synthetic Bone ◽  
Synthetic Bone Graft ◽  
Wedge High Tibial Osteotomy ◽  
In Vitro Stability

scholarly journals Effectiveness of antibiotic-laden synthetic bone graft materials: In vitro characterisation

Injury Extra ◽  
2012 ◽  
Vol 43 (10) ◽  
pp. 82
Author(s):  
A. Al Khudairy ◽  
J.P. Phelan ◽  
S.P. Hudson ◽  
O. O’Donovan ◽  
R. Galvin ◽  
...  
Keyword(s):  
Bone Graft ◽  
Synthetic Bone ◽  
Synthetic Bone Graft
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