scholarly journals PVC membrane, coated-wire, and carbon-paste ion-selective electrodes for potentiometric determination of galantamine hydrobromide in physiological fluids

2018 ◽  
Vol 89 ◽  
pp. 140-148 ◽  
Author(s):  
Fatehy M. Abdel-Haleem ◽  
Mohamed Saad ◽  
Ahmed Barhoum ◽  
Mikhael Bechelany ◽  
Mahmoud S. Rizk
Keyword(s):  
Potentiometric Determination ◽  
Pvc Membrane ◽  
Ion Selective Electrodes ◽  
Carbon Paste ◽  
Coated Wire

scholarly journals Potentiometric Determination of Ketotifen Fumarate in Pharmaceutical Preparations and Urine Using Carbon Paste and PVC Membrane Selective Electrodes

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Eman Y. Z. Frag ◽  
Gehad G. Mohamed ◽  
Mohamed M. Khalil ◽  
Mohammad M. A. Hwehy
Keyword(s):  
Biological Fluid ◽  
Pharmaceutical Preparations ◽  
Standard Addition ◽  
Selectivity Coefficient ◽  
Potentiometric Determination ◽  
Pvc Membrane ◽  
Membrane Electrodes ◽  
Carbon Paste ◽  
Ketotifen Fumarate

This study compares between unmodified carbon paste (CPE; the paste has no ion pair) and polyvinyl chloride (PVC) membrane selective electrodes that were used in potentiometric determination of ketotifen fumarate (KTF), where sodium tetraphenylborate (NaTPB) was used as titrant. The performance characteristics of these sensors were evaluated according to IUPAC recommendations which reveal a fast, stable, and linear response for KTF over the concentration range of 10−7to 10−2 mol L−1. The electrodes show Nernstian slope value of and  mV decade−1for CPE and PVC membrane electrodes at 30∘C, respectively. The potential is nearly stable over the pH range 3.0–6.0 and 2.0–7.0 for CPE and PVC membrane electrodes, respectively. Selectivity coefficient values towards different inorganic cations, sugars, and amino acids reflect high selectivity of the prepared electrodes. The electrodes responses at different temperatures were also studied, and long operational lifetime of 12 and 5 weeks for CPE and PVC membrane electrodes, respectively, were found. These are used for determination of ketotifen fumarate using potentiometric titration, calibration, and standard addition methods in pure samples, its pharmaceutical preparations (Zaditen tablets), and biological fluid (urine). The direct potentiometric determination of KTF using the proposed sensors gave recoveries % of and with RSD 1.42 and 0.63% for CPE and PVC membrane selective electrodes, respectively. Validation of the method shows suitability of the proposed sensors for use in quality control assessment of KTF. The obtained results were in a good agreement with those obtained using the reported spectrophotometric method.

All-Solid-State, PVC Membrane, and Carbon Paste Ion-Selective Electrodes for Determination of Donepezil Hydrochloride in Pharmaceutical Formulation

2017 ◽  
Vol 100 (5) ◽  
pp. 1414-1419
Author(s):  
Nesreen Khamees ◽  
Tagreed Abdel-Fattah Mohamed ◽  
Abeer Rashad Derar ◽  
Azza Aziz
Keyword(s):  
Solid State ◽  
Pharmaceutical Formulation ◽  
Pvc Membrane ◽  
Ion Selective Electrodes ◽  
Carbon Paste ◽  
Pharmaceutical Tablets ◽  
Carbon Paste Electrodes ◽  
Potentiometric Response ◽  
Donepezil Hydrochloride

Abstract All-solid-state, polyvinyl chloride (PVC) membrane, and carbon paste potentiometric ion-selective electrodes (ISEs) were proposed for the determination of donepezil hydrochloride (DON) in the drug substance and a pharmaceutical formulation. The potentiometric response toward DON was based on the existence ofdonepezil-tetraphenyl borate (DON-TPB) in a PVC membrane or a carbon paste in the presence of dioctylphthalate. In contrast, the solid-state electrode was prepared by direct incorporation of DON-TPB into a commercial nail varnish without external additives. The electrodes exhibited Nernstian slopes of 55.0, 57.0, and 53.0 mV/decade over the concentration ranges of 1 × 10−5 to 1 × 10−3, 1 × 10−4 to 10−2, and 1 × 10−4 to 5 × 10−3 for the solid-state, PVC membrane, and carbon paste electrodes, respectively. The response of the electrodes is independent of pH in the range of 2–≤8. The electrodes showed good selectivity for DON with respect to a number of inorganic cations and amino acids. The electrodes were used for the determination of DON in pure solution and in pharmaceutical tablets with high accuracy (±2%) and precision (RSD ≤2%). The solid-state electrode is simple, economical, and rapid when compared to the PVC membrane and carbon paste electrodes.

scholarly journals New Conventional Coated-Wire Ion-Selective Electrodes for Flow-Injection Potentiometric Determination of Chlordiazepoxide

2005 ◽  
Vol 21 (9) ◽  
pp. 1037-1042 ◽  
Author(s):  
Y. M. ISSA ◽  
N. T. ABDEL-GHANI ◽  
A. F. SHOUKRY ◽  
Howayda M. AHMED
Keyword(s):  
Flow Injection ◽  
Potentiometric Determination ◽  
Ion Selective Electrodes ◽  
Coated Wire

Ion Selective Electrodes for Potentiometric Determination of Tizanidine in Its Pharmaceutical Dosage Form

2016 ◽  
Vol 12 (3) ◽  
pp. 177-184 ◽  
Author(s):  
Gamal Abdel-Hafiz Mostafa ◽  
Mohammed Hefnawy ◽  
Mohammed Abounassif ◽  
Amer Alanazi ◽  
Abdulrahman Al-Majed ◽  
...  
Keyword(s):  
Dosage Form ◽  
Potentiometric Determination ◽  
Ion Selective Electrodes ◽  
Pharmaceutical Dosage Form

scholarly journals Polyvinyl Chloride Modified Carbon Paste Electrodes for Sensitive Determination of Levofloxacin Drug in Serum, Urine, and Pharmaceutical Formulations

Sensors ◽  
2021 ◽  
Vol 21 (9) ◽  
pp. 3150
Author(s):  
Fatehy M. Abdel-Haleem ◽  
Sonia Mahmoud ◽  
Nour Eldin T. Abdel-Ghani ◽  
Rasha Mohamed El Nashar ◽  
Mikhael Bechelany ◽  
...  
Keyword(s):  
Bacterial Infections ◽  
Pharmaceutical Preparation ◽  
Pharmaceutical Formulations ◽  
Selectivity Coefficient ◽  
Pvc Membrane ◽  
Carbon Paste ◽  
Serum Samples ◽  
Carbon Paste Electrodes ◽  
Antibiotic Drug

Levofloxacin (LF) is a medically important antibiotic drug that is used to treat a variety of bacterial infections. In this study, three highly sensitive and selective carbon paste electrodes (CPEs) were fabricated for potentiometric determination of the LF drug: (i) CPEs filled with carbon paste (referred to as CPE); (ii) CPE coated (drop-casted) with ion-selective PVC membrane (referred to as C-CPE); (iii) CPE filled with carbon paste modified with a plasticizer (PVC/cyclohexanone) (referenced as P-CPE). The CPE was formulated from graphite (Gr, 44.0%) and reduced graphene oxide (rGO, 3.0%) as the carbon source, tricresyl phosphate (TCP, 47.0%) as the plasticizer; sodium tetrakis[3,5-bis(trifluoromethyl)phenyl] borate (St-TFPMB, 1.0%) as the ion exchanger; and levofloxacinium-tetraphenylborate (LF-TPB, 5.0%) as the lipophilic ion pair. It showed a sub-Nernstian slope of 49.3 mV decade−1 within the LF concentration range 1.0 × 10−2 M to 1.0 × 10−5 M, with a detection limit of 1.0 × 10−5 M. The PVC coated electrode (C-CPE) showed improved sensitivity (in terms of slope, equal to 50.2 mV decade−1) compared to CPEs. After the incorporation of PVC paste on the modified CPE (P-CPE), the sensitivity increased at 53.5 mV decade−1, indicating such improvement. The selectivity coefficient (log KLF2+,Fe+3pot.) against different interfering species (Na+, K+, NH4+, Ca2+, Al3+, Fe3+, Glycine, Glucose, Maltose, Lactose) were significantly improved by one to three orders of magnitudes in the case of C-CPE and P-CPE, compared to CPEs. The modification with the PVC membrane coating significantly improved the response time and solubility of the LF-TPB within the electrode matrix and increased the lifetime. The constructed sensors were successfully applied for LF determination in pharmaceutical preparation (Levoxin® 500 mg), spiked urine, and serum samples with high accuracy and precision.

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