Magnetically targetable microcapsules display subtle changes in permeability and drug release in response to a biologically compatible low frequency alternating magnetic field

2019 ◽  
Vol 94 ◽  
pp. 647-655 ◽  
Author(s):  
Dong Luo ◽  
Robin N. Poston ◽  
David J. Gould ◽  
Gleb B. Sukhorukov
Nanoscale ◽  
2016 ◽  
Vol 8 (6) ◽  
pp. 3259-3263 ◽  
Author(s):  
Jie Fang ◽  
Yong Yang ◽  
Wen Xiao ◽  
Bingwen Zheng ◽  
Yun-Bo Lv ◽  
...  

An extremely low frequency alternating magnetic field of 20 Hz was proved to be able to remarkably accelerate the drug release from optimized ZIF-90 nanospheres with incorporated Fe3O4 nanoparticles acting as actuator.


Nanoscale ◽  
2018 ◽  
Vol 10 (23) ◽  
pp. 10918-10933 ◽  
Author(s):  
Edouard Alphandéry ◽  
Darine Abi Haidar ◽  
Olivier Seksek ◽  
François Guyot ◽  
Imène Chebbi

Therapeutic substances bound to nanoparticles have been shown to dissociate following excitation by various external sources of energies or chemical disturbance, resulting in controllable and efficient antitumor activity.


2014 ◽  
Vol 5 (10) ◽  
pp. 3311-3315 ◽  
Author(s):  
Alexander E. Dunn ◽  
Douglas J. Dunn ◽  
Alexander Macmillan ◽  
Renee Whan ◽  
Tim Stait-Gardner ◽  
...  

A novel theranostic controlled drug delivery platform that binds the drug to the nanocarrier by utilising Schiff base bonds to achieve high spatial and temporal control over drug release.


2021 ◽  
Vol 12 ◽  
pp. 1404-1412
Author(s):  
Elizaveta M Gubanova ◽  
Nikolai A Usov ◽  
Vladimir A Oleinikov

Low-frequency hysteresis loops and specific absorption rate (SAR) of various assemblies of elongated spheroidal magnetite nanoparticles have been calculated for a range of particle semiaxis ratios a/b = 1.0–3.0. The SAR of a dilute randomly oriented assembly of magnetite nanoparticles in an alternating magnetic field of moderate frequency, f = 300 kHz, and amplitude H0 = 100–200 Oe is shown to decrease significantly with an increase in the aspect ratio of nanoparticles. In addition, there is a narrowing and shift of the intervals of optimal particle diameters towards smaller particle sizes. However, the orientation of a dilute assembly of elongated nanoparticles in a magnetic field leads to an almost twofold increase in SAR at the same frequency and amplitude of the alternating magnetic field, the range of optimal particle diameters remaining unchanged. The effect of the magneto-dipole interaction on the SAR of a dilute assembly of oriented clusters of elongated magnetite nanoparticles has also been investigated depending on the volume fraction of nanoparticles in a cluster. It has been found that the SAR of the assembly of oriented clusters decreases by approximately an order of magnitude with an increase in the volume fraction of nanoparticles in a cluster in the range of 0.04–0.2.


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