Chronic hyperammonemia alters motor and neurochemical responses to activation of group i metabotropic glutamate receptors in the nucleus accumbens in rats in vivo

2003 ◽  
Vol 14 (3) ◽  
pp. 380-390 ◽  
Author(s):  
Juan-José Canales ◽  
Amina Elayadi ◽  
Mohammed Errami ◽  
Marta Llansola ◽  
Omar Cauli ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Glutamate Receptors ◽  
Metabotropic Glutamate Receptors ◽  
Metabotropic Glutamate ◽  
Group I

scholarly journals Functional Cross-Talk between Adenosine and Metabotropic Glutamate Receptors

2019 ◽  
Vol 17 (5) ◽  
pp. 422-437 ◽  
Author(s):  
David Agustín León-Navarro ◽  
José Luis Albasanz ◽  
Mairena Martín
Keyword(s):  
Neurodegenerative Diseases ◽  
Adenylyl Cyclase ◽  
Glutamate Receptors ◽  
G Protein ◽  
Metabotropic Glutamate Receptors ◽  
Metabotropic Glutamate ◽  
Group I ◽  
Gene And Protein Expression

G-protein coupled receptors are transmembrane proteins widely expressed in cells and their transduction pathways are mediated by controlling second messenger levels through different G-protein interactions. Many of these receptors have been described as involved in the physiopathology of neurodegenerative diseases and even considered as potential targets for the design of novel therapeutic strategies. Endogenous and synthetic allosteric and orthosteric selective ligands are able to modulate GPCRs at both gene and protein expression levels and can also modify their physiological function. GPCRs that coexist in the same cells can homo- and heteromerize, therefore, modulating their function. Adenosine receptors are GPCRs which stimulate or inhibit adenylyl cyclase activity through Gi/Gs protein and are involved in the control of neurotransmitter release as glutamate. In turn, metabotropic glutamate receptors are also GPCRs which inhibit adenylyl cyclase or stimulate phospholipase C activities through Gi or Gq proteins, respectively. In recent years, evidence of crosstalk mechanisms between different GPCRs have been described. The aim of the present review was to summarize the described mechanisms of interaction and crosstalking between adenosine and metabotropic glutamate receptors, mainly of group I, in both in vitro and in vivo systems, and their possible use for the design of novel ligands for the treatment of neurodegenerative diseases.

scholarly journals Phosphorylation of group I metabotropic glutamate receptors (mGluR1/5) in vitro and in vivo

2008 ◽  
Vol 55 (4) ◽  
pp. 403-408 ◽  
Author(s):  
Li-Min Mao ◽  
Xian-Yu Liu ◽  
Guo-Chi Zhang ◽  
Xiang-Ping Chu ◽  
Eugene E. Fibuch ◽  
...  
Keyword(s):  
Glutamate Receptors ◽  
Metabotropic Glutamate Receptors ◽  
Metabotropic Glutamate ◽  
Group I

Altered Modulation of Motor Activity by Group I Metabotropic Glutamate Receptors in the Nucleus Accumbens in Hyperammonemic Rats

2005 ◽  
Vol 20 (4) ◽  
pp. 347-358 ◽  
Author(s):  
Omar Cauli ◽  
Marta Llansola ◽  
Regina Rodrigo ◽  
Nisrin El Mlili ◽  
Mohammed Errami ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Motor Activity ◽  
Glutamate Receptors ◽  
Metabotropic Glutamate Receptors ◽  
Metabotropic Glutamate ◽  
Group I
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