Homocysteine-Evoked45Ca Release in the Rabbit Hippocampus Is Mediated by Both NMDA and Group I Metabotropic Glutamate Receptors: In Vivo Microdialysis Study

2003 ◽  
Vol 28 (2) ◽  
pp. 259-269 ◽  
Author(s):  
Jerzy W. Lazarewicz ◽  
Apolonia Ziembowicz ◽  
Ewa Matyja ◽  
Aleksandra Stafiej ◽  
Elzbieta Zieminska
Keyword(s):  
Glutamate Receptors ◽  
Metabotropic Glutamate Receptors ◽  
In Vivo Microdialysis ◽  
Metabotropic Glutamate ◽  
Rabbit Hippocampus ◽  
Group I ◽  
Microdialysis Study

scholarly journals Functional Cross-Talk between Adenosine and Metabotropic Glutamate Receptors

2019 ◽  
Vol 17 (5) ◽  
pp. 422-437 ◽  
Author(s):  
David Agustín León-Navarro ◽  
José Luis Albasanz ◽  
Mairena Martín
Keyword(s):  
Neurodegenerative Diseases ◽  
Adenylyl Cyclase ◽  
Glutamate Receptors ◽  
G Protein ◽  
Metabotropic Glutamate Receptors ◽  
Metabotropic Glutamate ◽  
Group I ◽  
Gene And Protein Expression

G-protein coupled receptors are transmembrane proteins widely expressed in cells and their transduction pathways are mediated by controlling second messenger levels through different G-protein interactions. Many of these receptors have been described as involved in the physiopathology of neurodegenerative diseases and even considered as potential targets for the design of novel therapeutic strategies. Endogenous and synthetic allosteric and orthosteric selective ligands are able to modulate GPCRs at both gene and protein expression levels and can also modify their physiological function. GPCRs that coexist in the same cells can homo- and heteromerize, therefore, modulating their function. Adenosine receptors are GPCRs which stimulate or inhibit adenylyl cyclase activity through Gi/Gs protein and are involved in the control of neurotransmitter release as glutamate. In turn, metabotropic glutamate receptors are also GPCRs which inhibit adenylyl cyclase or stimulate phospholipase C activities through Gi or Gq proteins, respectively. In recent years, evidence of crosstalk mechanisms between different GPCRs have been described. The aim of the present review was to summarize the described mechanisms of interaction and crosstalking between adenosine and metabotropic glutamate receptors, mainly of group I, in both in vitro and in vivo systems, and their possible use for the design of novel ligands for the treatment of neurodegenerative diseases.

scholarly journals Phosphorylation of group I metabotropic glutamate receptors (mGluR1/5) in vitro and in vivo

2008 ◽  
Vol 55 (4) ◽  
pp. 403-408 ◽  
Author(s):  
Li-Min Mao ◽  
Xian-Yu Liu ◽  
Guo-Chi Zhang ◽  
Xiang-Ping Chu ◽  
Eugene E. Fibuch ◽  
...  
Keyword(s):  
Glutamate Receptors ◽  
Metabotropic Glutamate Receptors ◽  
Metabotropic Glutamate ◽  
Group I
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