Experimental basis for the putative role of GluR6/kainate glutamate receptor subunit in Huntington's disease natural history

2004 ◽  
Vol 15 (3) ◽  
pp. 667-675 ◽  
Author(s):  
Elsa Diguet ◽  
Pierre-Olivier Fernagut ◽  
Elisabeth Normand ◽  
Laurie Centelles ◽  
Christophe Mulle ◽  
...  
Keyword(s):  
Natural History ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Glutamate Receptor ◽  
Receptor Subunit ◽  
Experimental Basis ◽  
Glutamate Receptor Subunit ◽  
Putative Role

The Role of Melatonin in Multiple Sclerosis, Huntington's Disease and Cerebral Ischemia

2014 ◽  
Vol 13 (6) ◽  
pp. 1096-1119 ◽  
Author(s):  
Begona Escribano ◽  
Ana Colin-Gonzalez ◽  
Abel Santamaria ◽  
Isaac Tunez
Keyword(s):  
Multiple Sclerosis ◽  
Cerebral Ischemia ◽  
Huntington's Disease ◽  
Huntington’S Disease

Molecular and electrophysiological characterizations of fGluR3α, an ionotropic glutamate receptor subunit of a teleost fish

1998 ◽  
Vol 57 (2) ◽  
pp. 211-220 ◽  
Author(s):  
Hsiu-Ming Chang ◽  
Yi-Mi Wu ◽  
Yen-Chung Chang ◽  
Yu-Chung Hsu ◽  
Hsiu-Ya Hsu ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Teleost Fish ◽  
Ionotropic Glutamate Receptor ◽  
Receptor Subunit ◽  
Glutamate Receptor Subunit

scholarly journals The Role of Pretraining on Skilled Forelimb Use in an Animal Model of Huntington's Disease

2003 ◽  
Vol 12 (3) ◽  
pp. 257-264 ◽  
Author(s):  
R. A. Fricker-Gates ◽  
R. Smith ◽  
J. Muhith ◽  
S. B. Dunnett
Keyword(s):  
Animal Model ◽  
Huntington's Disease ◽  
Huntington’S Disease

scholarly journals A modular tool to query and inducibly disrupt biomolecular condensates

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Carmen N. Hernández-Candia ◽  
Sarah Pearce ◽  
Chandra L. Tucker
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Cellular Function ◽  
Biological Role ◽  
Cellular Biology ◽  
Condensate Formation ◽  
Health And Disease ◽  
Lateral Sclerosis

AbstractDynamic membraneless compartments formed by protein condensates have multifunctional roles in cellular biology. Tools that inducibly trigger condensate formation have been useful for exploring their cellular function, however, there are few tools that provide inducible control over condensate disruption. To address this need we developed DisCo (Disassembly of Condensates), which relies on the use of chemical dimerizers to inducibly recruit a ligand to the condensate-forming protein, triggering condensate dissociation. We demonstrate use of DisCo to disrupt condensates of FUS, associated with amyotrophic lateral sclerosis, and to prevent formation of polyglutamine-containing huntingtin condensates, associated with Huntington’s disease. In addition, we combined DisCo with a tool to induce condensates with light, CRY2olig, achieving bidirectional control of condensate formation and disassembly using orthogonal inputs of light and rapamycin. Our results demonstrate a method to manipulate condensate states that will have broad utility, enabling better understanding of the biological role of condensates in health and disease.

scholarly journals Transmembrane topology of the glutamate receptor subunit GluR6.

1994 ◽  
Vol 269 (16) ◽  
pp. 11679-11682
Author(s):  
K.W. Roche ◽  
L.A. Raymond ◽  
C. Blackstone ◽  
R.L. Huganir
Keyword(s):  
Glutamate Receptor ◽  
Receptor Subunit ◽  
Transmembrane Topology ◽  
Glutamate Receptor Subunit
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