scholarly journals Active immunization with tau epitope in a mouse model of tauopathy induced strong antibody response together with improvement in short memory and pSer396-tau pathology

2020 ◽  
Vol 134 ◽  
pp. 104636 ◽  
Author(s):  
A. Joly-Amado ◽  
H. Davtyan ◽  
K. Serraneau ◽  
P. Jules ◽  
A. Zitnyar ◽  
...  
Keyword(s):  
Mouse Model ◽  
Antibody Response ◽  
Active Immunization ◽  
Tau Pathology ◽  
Strong Antibody Response ◽  
Short Memory

scholarly journals Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

2012 ◽  
Vol 11 (4) ◽  
pp. 165-181 ◽  
Author(s):  
Maj-Linda B. Selenica ◽  
Milene Brownlow ◽  
Jeffy P. Jimenez ◽  
Daniel C. Lee ◽  
Gabriela Pena ◽  
...  
Keyword(s):  
Mouse Model ◽  
Tau Pathology ◽  
Amyloid Oligomers

Zinc Exacerbates Tau Pathology in a Tau Mouse Model

2018 ◽  
Vol 64 (2) ◽  
pp. 617-630 ◽  
Author(s):  
Kristen M. Craven ◽  
William R. Kochen ◽  
Carlos M. Hernandez ◽  
Jane M. Flinn
Keyword(s):  
Mouse Model ◽  
Tau Pathology ◽  
Tau Mouse Model

A mouse model to study tau pathology related with tau phosphorylation and assembly

2007 ◽  
Vol 257 (1-2) ◽  
pp. 250-254 ◽  
Author(s):  
Tobias Engel ◽  
José J. Lucas ◽  
Félix Hernández ◽  
Jesús Avila
Keyword(s):  
Mouse Model ◽  
Tau Phosphorylation ◽  
Tau Pathology

scholarly journals Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease

Neuroscience ◽  
2016 ◽  
Vol 315 ◽  
pp. 162-174 ◽  
Author(s):  
T.L. Platt ◽  
T.L. Beckett ◽  
K. Kohler ◽  
D.M. Niedowicz ◽  
M.P. Murphy
Keyword(s):  
Mouse Model ◽  
Leptin Resistance ◽  
Tau Pathology

scholarly journals PATHOGENESIS OF THE GLOMERULONEPHRITIS OF NZB/W MICE

1968 ◽  
Vol 127 (3) ◽  
pp. 507-522 ◽  
Author(s):  
P. H. Lambert ◽  
Frank J. Dixon
Keyword(s):  
Antibody Response ◽  
Antinuclear Antibody ◽  
Active Immunization ◽  
Rapid Progression ◽  
Nuclear Antigens ◽  
Glomerular Lesions ◽  
Dna Antibodies ◽  
Capillary Walls

The development of glomerulonephritis in NZB/W mice is closely related to the formation of antinuclear, particularly anti-DNA, antibodies. The developing inflammatory glomerular lesions are characterized by the deposition of γG- and ß1C-globulins plus DNA and possibly other nuclear antigens, presumably as complexes, in a granular to lumpy pattern along the capillary walls and in the mesangia. Elution studies revealed the γG-globulin in the glomeruli to be largely γG2A-type antibody to soluble nuclear antigens. Enhancement of the antinuclear antibody response by active immunization of young NZB/W mice with DNA-methylated BSA hastens the development and increases the severity of the glomerulonephritis. Similarly, injections of soluble DNA into NZB/W mice with circulating anti-DNA antibodies but with as yet little nephritis causes rapid progression of nephritis.

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