The mRNA expression of AMPA type glutamate receptors in the primary motor cortex of patients with amyotrophic lateral sclerosis: an in situ hybridization study

2004 ◽  
Vol 360 (3) ◽  
pp. 170-174 ◽  
Author(s):  
Susanne Petri ◽  
Klaus Krampfl ◽  
Fariba Hashemi ◽  
Sonja Schmalbach ◽  
Claudia Grothe ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
In Situ Hybridization ◽  
Motor Cortex ◽  
Mrna Expression ◽  
Glutamate Receptors ◽  
Primary Motor Cortex ◽  
Hybridization Study ◽  
Lateral Sclerosis

scholarly journals First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Agessandro Abrahao ◽  
Ying Meng ◽  
Maheleth Llinas ◽  
Yuexi Huang ◽  
Clement Hamani ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Motor Cortex ◽  
Blood Brain Barrier ◽  
Focused Ultrasound ◽  
Primary Motor Cortex ◽  
Brain Barrier ◽  
Human Trial ◽  
Blood Brain ◽  
Lateral Sclerosis ◽  
Bbb Opening

Abstract MR-guided focused ultrasound (MRgFUS) is an emerging technology that can accurately and transiently permeabilize the blood-brain barrier (BBB) for targeted drug delivery to the central nervous system. We conducted a single-arm, first-in-human trial to investigate the safety and feasibility of MRgFUS-induced BBB opening in eloquent primary motor cortex in four volunteers with amyotrophic lateral sclerosis (ALS). Here, we show successful BBB opening using MRgFUS as demonstrated by gadolinium leakage at the target site immediately after sonication in all subjects, which normalized 24 hours later. The procedure was well-tolerated with no serious clinical, radiologic or electroencephalographic adverse events. This study demonstrates that non-invasive BBB permeabilization over the motor cortex using MRgFUS is safe, feasible, and reversible in ALS subjects. In future, MRgFUS can be coupled with promising therapeutics providing a targeted delivery platform in ALS.

scholarly journals Magnetic susceptibility in the deep layers of the primary motor cortex in Amyotrophic Lateral Sclerosis

2016 ◽  
Vol 12 ◽  
pp. 965-969 ◽  
Author(s):  
M. Costagli ◽  
G. Donatelli ◽  
L. Biagi ◽  
E. Caldarazzo Ienco ◽  
G. Siciliano ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Magnetic Susceptibility ◽  
Motor Cortex ◽  
Primary Motor Cortex ◽  
Deep Layers ◽  
Lateral Sclerosis

Changes in cholecystokinin mRNA expression after amygdala kindled seizures: an in situ hybridization study

1996 ◽  
Vol 35 (1-2) ◽  
pp. 278-284 ◽  
Author(s):  
Li-Xin Zhang ◽  
Mark A. Smith ◽  
Su-Yong Kim ◽  
Jeffrey B. Rosen ◽  
Susan R.B. Weiss ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Mrna Expression ◽  
Hybridization Study ◽  
Kindled Seizures
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