Role of pituitary adenylate cyclase-activating polypeptide (PACAP) in the action of ginsenoside Rh2 against beta-amyloid-induced inhibition of rat brain astrocytes

2008 ◽  
Vol 434 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Po-Chuen Shieh ◽  
Chiung-Wen Tsao ◽  
Jin-Shiou Li ◽  
Hung-Tsung Wu ◽  
Ya-Ju Wen ◽  
...  
Keyword(s):  
Adenylate Cyclase ◽  
Rat Brain ◽  
Beta Amyloid ◽  
Ginsenoside Rh2 ◽  
Pituitary Adenylate Cyclase

The expression of pituitary adenylate cyclase-activating polypeptide (PACAP) mRNA in rat brain: possible role of endogenous PACAP in vasopressin release

1995 ◽  
Vol 185 (2) ◽  
pp. 103-106 ◽  
Author(s):  
Takashi Murase ◽  
Kunikazu Kondo ◽  
Hiroshi Arima ◽  
Yasumasa Iwasaki ◽  
Masafumi Ito ◽  
...  
Keyword(s):  
Adenylate Cyclase ◽  
Rat Brain ◽  
Vasopressin Release ◽  
Pituitary Adenylate Cyclase

scholarly journals Stimulation of Cyclic AMP Formation by Pituitary Adenylate Cyclase-Activating Polypeptide Is Attenuated by Glutamate in Rat Brain Slices

1995 ◽  
Vol 67 (4) ◽  
pp. 399-402
Author(s):  
Kaoru Kondo ◽  
Hitoshi Hashimoto ◽  
Kazuko Sakata ◽  
Hiroshi Saga ◽  
Jun-ichi Kitanaka ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Adenylate Cyclase ◽  
Rat Brain ◽  
Brain Slices ◽  
Pituitary Adenylate Cyclase ◽  
Stimulation Of

scholarly journals Emerging Role of PACAP as a New Potential Therapeutic Target in Major Diabetes Complications

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Rubina Marzagalli ◽  
Soraya Scuderi ◽  
Filippo Drago ◽  
James A. Waschek ◽  
Alessandro Castorina
Keyword(s):  
Life Expectancy ◽  
Adenylate Cyclase ◽  
Diabetes Complications ◽  
Increase Life Expectancy ◽  
Potential Therapeutic Target ◽  
Future Directions ◽  
Major Complications ◽  
Secondary Damage ◽  
Pituitary Adenylate Cyclase

Enduring diabetes increases the probability of developing secondary damage to numerous systems, and these complications represent a cause of morbidity and mortality. Establishing the causes of diabetes remains the key step to eradicate the disease, but prevention as well as finding therapies to ameliorate some of the major diabetic complications is an equally important step to increase life expectancy and quality for the millions of individuals already affected by the disease or who are likely to develop it before cures become routinely available. In this review, we will firstly summarize some of the major complications of diabetes, including endothelial and pancreatic islets dysfunction, retinopathy, and nephropathy, and then discuss the emerging roles exerted by the neuropeptide pituitary adenylate cyclase activating polypeptide (PACAP) to counteract these ranges of pathologies that are precipitated by the prolonged hyperglycemic state. Finally, we will describe the main signalling routes activated by the peptide and propose possible future directions to focus on developing more effective peptide-based therapies to treat the major complications associated with longstanding diabetes.

Sign in / Sign up

Export Citation Format

Share Document