scholarly journals High incidence of adverse cerebral blood flow responses to spreading depolarization in the aged ischemic rat brain

2015 ◽  
Vol 36 (12) ◽  
pp. 3269-3277 ◽  
Author(s):  
Ákos Menyhárt ◽  
Péter Makra ◽  
Borbála É. Szepes ◽  
Orsolya M. Tóth ◽  
Péter Hertelendy ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Rat Brain ◽  
Spreading Depolarization ◽  
High Incidence

scholarly journals Erratum

1991 ◽  
Vol 11 (4) ◽  
pp. 706-706
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Equilibrium State ◽  
Rat Brain ◽  
G Proteins ◽  
Pertussis Toxin ◽  
Adp Ribosylation ◽  
Gtp Binding ◽  
Reconstituted System ◽  
Α Subunits

Ischemia of Rat Brain Decreases Pertussis Toxin-Catalyzed [32P] ADP Ribosylation of GTP-Binding Proteins (Gi1 and G0) in Membranes Katsunobu Takenaka, Yasunori Kanaho, Koh-ichi Nagata, Noboru Sakai, Hiromu Yamada, Yoshinori Nozawa [ Originally published in Journal of Cerebral Blood Flow and Metabolism 1991;11:155–160] On page 158 of the above, arrows were erroneously deleted from the equation in the following passage: Heterotrimers of G proteins that bind GDP to α subunits seem to be the preferred substrates for PTcatalyzed ADP ribosylation since guanine nucleotides (GDP and GTP) and 13'Y subunits stimulate ADP ribosylation in the reconstituted system and in membranes (Tsai et aI., 1984). These results indicate that the G proteins may exist at the equilibrium state as shown below: This omission was the result of a typesetting error, which the publisher regrets.

Early cerebral blood flow and computerized tomography in predicting ischemia after cerebral aneurysm rupture

1985 ◽  
Vol 62 (6) ◽  
pp. 850-855 ◽  
Author(s):  
Neville W. Knuckey ◽  
Richard A. Fox ◽  
Ivor Surveyor ◽  
Bryant A. R. Stokes
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cerebral Ischemia ◽  
Computerized Tomography ◽  
Aneurysm Rupture ◽  
Clinical Grade ◽  
Content Type ◽  
Ruptured Intracranial Aneurysm ◽  
High Incidence ◽  
Subarachnoid Blood

✓ Cerebral blood flow (CBF) was measured during the 1st week of subarachnoid hemorrhage in 46 patients who were in a good clinical grade and had a proven ruptured intracranial aneurysm. The mean initial CBF in patients who developed cerebral ischemia was 42 ml/min−1/l00 gm brain−1, which was significantly lower than in patients who did not develop cerebral ischemia (49 ml/min−1/l00 gm brain−1). This reduced CBF was not secondary to raised intracranial pressure or angiographic spasm. Patients with a reduced CBF (less than 50 ml/min−1/100 gm brain−1) and diffuse subarachnoid blood on computerized tomography had a very high incidence (78%) of cerebral ischemia, despite a good clinical grade at the time of measurement. Serial CBF measurements are of value in monitoring the evolution of cerebral vasospasm.

Diffuse optical tomography of hemoglobin concentrations, and cerebral blood flow in rat brain during focal ischemia.

2002 ◽  
Author(s):  
Joseph P. Culver ◽  
Daisuke Furuya ◽  
Joel H. Greenberg ◽  
Turgut Durduran ◽  
Cecil Cheung ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Rat Brain ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Focal Ischemia

Cerebral blood flow and oxygen consumption in the rat brain after lesions of the noradrenergic locus coeruleus system

1981 ◽  
Vol 209 (1) ◽  
pp. 11-23 ◽  
Author(s):  
N. Dahlgren ◽  
O. Lindvall ◽  
T. Sakabe ◽  
U. Stenevi ◽  
B.K. Siesjö
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Oxygen Consumption ◽  
Locus Coeruleus ◽  
Rat Brain

Local cerebral blood flow in the rat brain during hypercapnia and hypoxia

1983 ◽  
Vol 118 (4) ◽  
pp. 439-440 ◽  
Author(s):  
MAJ-LIS SMITH ◽  
ERIK KÅGSTRÖM ◽  
BO K. SIESJÖ
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Rat Brain ◽  
Local Cerebral Blood Flow

Effect of transient reduction of cerebral blood flow on membrane anisotropy and lipid peroxidation in different rat brain areas

1994 ◽  
Vol 25 (2) ◽  
pp. 161-168 ◽  
Author(s):  
Mira Melzacka ◽  
Nina Weiner ◽  
Christine Heim ◽  
Rainald Schmidt-Kastner ◽  
Maria Sieklucka ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Rat Brain ◽  
Brain Areas

Inhibition of brain P-450 arachidonic acid epoxygenase decreases baseline cerebral blood flow

1996 ◽  
Vol 271 (4) ◽  
pp. H1541-H1546 ◽  
Author(s):  
N. J. Alkayed ◽  
E. K. Birks ◽  
A. G. Hudetz ◽  
R. J. Roman ◽  
L. Henderson ◽  
...  
Keyword(s):  
Blood Flow ◽  
Arachidonic Acid ◽  
Cerebral Blood Flow ◽  
Rat Brain ◽  
Cerebral Microvessels ◽  
Doppler Flowmetry ◽  
Time Control ◽  
Cultured Astrocytes ◽  
Brain Parenchymal ◽  
Cerebrovascular Smooth Muscle Cells

Arachidonic acid (AA) is metabolized by the cytochrome P-450 (P-450) epoxygenase pathway to epoxyeicosatrienoic acids (EETs) in the brain parenchymal tissue and perivascular astrocytes. EETs dilate cerebral microvessels and enhance K+ current in cerebrovascular smooth muscle cells. In the current study, the effect of a subdural administration of miconazole, an inhibitor of P-450 epoxygenase, on microvascular perfusion of rat cerebral cortex was evaluated using laser-Doppler flowmetry (LDF) Baseline cerebral blood flow (CBF) decreased by 29.7 +/- 7.3% (n = 5) after administration of 20 microM miconazole into the subdural space for 30 min. Responses of CBF to sodium nitroprusside and 5-hydroxytryptamine were unaltered by miconazole treatment. Administration of vehicle alone in time-control experiments had no effect on CBF. In other experiments, the effects of miconazole on the metabolism of [14C]AA by cultured rat astrocytes and on nitric oxide synthase activity in homogenates of rat brain were examined. Miconazole inhibited conversion of AA to EETs by cultured astrocytes but had no effect on the conversion of L-arginine to L-citrulline by homogenates of rat brain. These results implicate endogenous P-450 epoxides of AA in the regulation of basal blood flow in cerebral microcirculation.

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