Modulation of Brain Networks during MR-Compatible Transcranial Direct Current Stimulation

AbstractTranscranial direct current stimulation (TDCS) has been widely used to improve cognitive function. However, current deficiencies in mechanistic understanding hinders wider applicability. To clarify its physiological effects, we acquired fMRI whilst simultaneously acquiring TDCS to the right inferior frontal gyrus (rIFG) of healthy human participants, a region involved in coordinating activity within brain networks. TDCS caused widespread modulation of network activity depending on brain state (‘rest’ or choice reaction time task) and polarity (anodal or cathodal). During task, TDCS increased salience network activation and default mode network deactivation, but had the opposite effect during ‘rest’. Furthermore, there was an interaction between brain state and TDCS polarity, with cathodal effects more pronounced during task performance and anodal effects more pronounced during ‘rest’. Overall, we show that rIFG TDCS produces brain state and polarity dependent effects within large-scale cognitive networks, in a manner that goes beyond predictions from the current literature.

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Effects of transcranial direct current stimulation on brain networks related to creative thinking

10.1101/2020.03.08.981506 ◽

2020 ◽

Cited By ~ 1

Author(s):

Koji Koizumi ◽

Kazutaka Ueda ◽

Ziyang Li ◽

Masayuki Nakao

Keyword(s):

Direct Current ◽

Transcranial Direct Current Stimulation ◽

Creative Thinking ◽

Large Scale ◽

Brain Networks ◽

Temporal Cortex ◽

Brain Network ◽

Creative Performance ◽

Direct Current Stimulation ◽

Delta Band

AbstractHuman creative thinking is unique and capable of generating novel and valuable ideas. Recent research has clarified the contribution of different brain networks (default mode network, DN; executive control network; salience network) to creative thinking. However, the effects of brain stimulation on brain networks during creative thinking and on creative performance have not been clarified. The present study was designed to examine the changes in functional connectivity (FC) and effective connectivity (EC) of the large-scale brain network, and the ensuing changes in creative performance, induced by transcranial direct current stimulation (tDCS). Fourteen healthy male students underwent two tDCS sessions, one with actual stimulation and one with sham stimulation, on two separate days. Participants underwent tDCS (anode over the left dorsolateral prefrontal cortex, DLPFC; cathode over the right inferior parietal lobule, IPL) for 20 minutes. Before and after the tDCS session, electroencephalography signals were acquired from 32 electrodes over the whole head during the creative thinking task. On FC analysis, the delta band FC between the posterior cingulate cortex and IPL significantly increased only after real stimulation. We also found that the change of flexibility score was significantly correlated with the change in (i) delta band FC between mPFC and left lateral temporal cortex (LTC) and (ii) alpha band FC between IPL and right LTC. On EC analysis, decreased flow within the DN (from left LTC to right IPL) was observed. Our results reveal that tDCS could affect brain networks, particularly the DN, during creative thinking and modulate key FC in the generation of flexible creative ideas.

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Efficacy of Cathodal Transcranial Direct Current Stimulation on Brain Networks in Patients with Focal Epilepsy

Brain Stimulation ◽

10.1016/j.brs.2018.12.335 ◽

2019 ◽

Vol 12 (2) ◽

pp. 413

Author(s):

W. Luo ◽

h liu ◽

P. Zhang ◽

J. Ding

Keyword(s):

Direct Current ◽

Transcranial Direct Current Stimulation ◽

Focal Epilepsy ◽

Brain Networks ◽

Direct Current Stimulation

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Measuring the Effect of Transcranial Direct Current Stimulation (tDCS) on Large-Scale Brain Networks With Simultaneous Functional Magnetic Resonance Imaging (fMRI)

Biological Psychiatry ◽

10.1016/j.biopsych.2020.02.1052 ◽

2020 ◽

Vol 87 (9) ◽

pp. S412

Author(s):

Sarah Aronson Fischell ◽

Thomas Ross ◽

Zhi-De Deng ◽

Betty Jo Salmeron ◽

Elliot A. Stein

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Functional Magnetic Resonance Imaging ◽

Direct Current ◽

Transcranial Direct Current Stimulation ◽

Large Scale ◽

Brain Networks ◽

Functional Magnetic Resonance ◽

Resonance Imaging ◽

Direct Current Stimulation

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Effects of Transcranial Direct Current Stimulation on Brain Networks Related to Creative Thinking

Frontiers in Human Neuroscience ◽

10.3389/fnhum.2020.541052 ◽

2020 ◽

Vol 14 ◽

Author(s):

Koji Koizumi ◽

Kazutaka Ueda ◽

Ziyang Li ◽

Masayuki Nakao

Keyword(s):

Direct Current ◽

Transcranial Direct Current Stimulation ◽

Creative Thinking ◽

Brain Networks ◽

Direct Current Stimulation

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Bilateral Transcranial Direct Current Stimulation Reshapes Resting-State Brain Networks: A Magnetoencephalography Assessment

Neural Plasticity ◽

10.1155/2018/2782804 ◽

2018 ◽

Vol 2018 ◽

pp. 1-10 ◽

Cited By ~ 6

Author(s):

Giovanni Pellegrino ◽

Matteo Maran ◽

Cristina Turco ◽

Luca Weis ◽

Giovanni Di Pino ◽

...

Keyword(s):

Direct Current ◽

Transcranial Direct Current Stimulation ◽

Resting State ◽

Brain Plasticity ◽

Brain Networks ◽

Network Activity ◽

Double Blind Study ◽

Double Blind ◽

Direct Current Stimulation ◽

Alpha Beta

Transcranial direct current stimulation (tDCS) can noninvasively induce brain plasticity, and it is potentially useful to treat patients affected by neurological conditions. However, little is known about tDCS effects on resting-state brain networks, which are largely involved in brain physiological functions and in diseases. In this randomized, sham-controlled, double-blind study on healthy subjects, we have assessed the effect of bilateral tDCS applied over the sensorimotor cortices on brain and network activity using a whole-head magnetoencephalography system. Bilateral tDCS, with the cathode (−) centered over C4 and the anode (+) centered over C3, reshapes brain networks in a nonfocal fashion. Compared to sham stimulation, tDCS reduces left frontal alpha, beta, and gamma power and increases global connectivity, especially in delta, alpha, beta, and gamma frequencies. The increase of connectivity is consistent across bands and widespread. These results shed new light on the effects of tDCS and may be of help in personalizing treatments in neurological disorders.

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