Cyclooxygenase and nitric oxide synthase in the presympathetic neurons in the paraventricular hypothalamic nucleus are involved in restraint stress-induced sympathetic activation in rats

Neuroscience ◽  
2010 ◽  
Vol 170 (3) ◽  
pp. 773-781 ◽  
Author(s):  
N. Yamaguchi ◽  
S. Ogawa ◽  
S. Okada
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Restraint Stress ◽  
Hypothalamic Nucleus ◽  
Sympathetic Activation ◽  
Paraventricular Hypothalamic Nucleus ◽  
Oxide Synthase

Testosterone production in mice lacking inducible nitric oxide synthase expression is sensitive to restraint stress

2007 ◽  
Vol 292 (2) ◽  
pp. E615-E620 ◽  
Author(s):  
Ben A. Weissman ◽  
Chantal M. Sottas ◽  
Ping Zhou ◽  
Costantino Iadecola ◽  
Matthew P. Hardy
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Restraint Stress ◽  
Immobilization Stress ◽  
Male Mice ◽  
Wild Type ◽  
Basal Plasma ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Immobilization stress (IMO) induces a rapid increase in glucocorticoid secretion [in rodents, corticosterone CORT)] and this is associated with decreased circulating testosterone (T) levels. Nitric oxide (NO), a reactive free radical and neurotransmitter, has been reported to be produced at higher rates in tissues such as brain during stress. The biosynthesis of T is also known to be dramatically suppressed by NO. Specifically, the inducible isoform of nitric oxide synthase (iNOS) was directly implicated in this suppression. To assess the respective roles of CORT and NO in stress-mediated inhibition of T production, adult wild-type (WT) and inducible nitric oxide synthase knockout (iNOS−/−) male mice were evaluated. Animals of each genotype were assigned to either basal control or 3-h IMO groups. Basal plasma and testicular T levels were equivalent in both genotypes, whereas testicular weights of mutant mice were significantly higher compared with WT animals. Exposure to 3-h IMO increased plasma CORT and decreased T concentrations in mice of both genotypes. Testicular T levels were also affected by stress in WT and mutant males, being sharply reduced in both genotypes. However, the concentrations of nitrite and nitrate, the stable metabolites of NO measured in testicular extracts, did not differ between control and stressed WT and iNOS−/− mice. These results support the hypothesis that CORT, but not NO, is a plausible candidate to mediate rapid stress-induced suppression of Leydig cell steroidogenesis.

Nitric oxide synthase isozymes in spinally projecting PVN neurons are involved in CRF-induced sympathetic activation

2009 ◽  
Vol 148 (1-2) ◽  
pp. 83-89 ◽  
Author(s):  
Naoko Yamaguchi ◽  
Shoshiro Okada ◽  
Daisuke Usui ◽  
Kunihiko Yokotani
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Sympathetic Activation ◽  
Oxide Synthase

Involvement of neuronal nitric oxide synthase in restraint stress-induced fever in rats

2002 ◽  
Vol 75 (1-2) ◽  
pp. 261-266 ◽  
Author(s):  
Daniela B Sanches ◽  
Alexandre A Steiner ◽  
Luiz G.S Branco
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Restraint Stress ◽  
Neuronal Nitric Oxide Synthase ◽  
Oxide Synthase

Alterations in glutathione levels of brain structures caused by acute restraint stress and by nitric oxide synthase inhibition but not by intraspecific agonistic interaction

2006 ◽  
Vol 166 (1) ◽  
pp. 71-77 ◽  
Author(s):  
Daniel Mathias Ghizoni ◽  
Kelly Cristine Alves Pavanati ◽  
André Mendes Arent ◽  
Claudia Machado ◽  
Moacir Serralvo Faria ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Restraint Stress ◽  
Brain Structures ◽  
Agonistic Interaction ◽  
Acute Restraint Stress ◽  
Oxide Synthase
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