A characterization of white matter pathology following spinal cord compression injury in the rat

Neuroscience ◽  
2014 ◽  
Vol 260 ◽  
pp. 227-239 ◽  
Author(s):  
R.E. Ward ◽  
W. Huang ◽  
M. Kostusiak ◽  
P.N. Pallier ◽  
A.T. Michael-Titus ◽  
...  
Keyword(s):  
Spinal Cord ◽  
White Matter ◽  
Spinal Cord Compression ◽  
Cord Compression ◽  
Compression Injury ◽  
White Matter Pathology

A remotely controlled model of spinal cord compression injury in mice: toward real-time analysis

2009 ◽  
Vol 11 (4) ◽  
pp. 461-470 ◽  
Author(s):  
Pascal Kouyoumdjian ◽  
Nicolas Lonjon ◽  
Monica Prieto ◽  
Henri Haton ◽  
Alain Privat ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Mr Imaging ◽  
Real Time ◽  
Spinal Cord Compression ◽  
Spinal Cord Injuries ◽  
Cord Compression ◽  
Genetically Engineered ◽  
In Vivo Studies ◽  
Compression Injury

Object To date, there has been no efficient therapeutic approach to spinal cord injuries (SCIs). This may be attributable, at least in part, to difficulties in forming predictive and accurate experimental animal models. The authors' previous studies have identified 2 relevant conditions of such a model. The first condition is the ability to compare data derived from rat models of SCI by developing mouse models of SCI that permit access to a large range of transgenic models. The second condition is that the exploration of the consequences of each mechanism of spinal trauma requires modeling the different etiologic aspects of the injury. Methods To fulfill these 2 conditions a new model of mouse spinal cord compression injury was devised using a thread-driven olive-shaped compressive device. The authors characterized early motor, sensory, and histological outcomes using 3 olive diameters and different compression durations. Results A gradual and reproducible functional severity that correlated with lesion extension was demonstrated in 76 mice. To further substantiate the characterization of this model, a noncompetitive N-methyl-d-aspartate antagonist was administered in 30 mice, which demonstrated the involvement of excitotoxicity in this model. Conclusions The study demonstrated that spinal olive-compression injury in the mouse is a reproducible, well-characterized, and predictable model for analyzing early events after SCI. The nonmagnetic and remotely controlled design of this model will allow completion of the lesion while the animal is in the MR imaging apparatus, thus permitting further real-time MR imaging studies that will provide insights into the characterization of early events in the spatial and temporal evolution of SCI. Moreover, this model lays the foundation for future in vivo studies of functional and histological outcomes following SCI in genetically engineered animals.

Characterization of axonal ultrastructural pathology following experimental spinal cord compression injury

1995 ◽  
Vol 702 (1-2) ◽  
pp. 1-16 ◽  
Author(s):  
David L. Anthes ◽  
Elizabeth Theriault ◽  
Charles H. Tator
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Compression ◽  
Cord Compression ◽  
Compression Injury ◽  
Ultrastructural Pathology

MRI evidence of brain atrophy, white matter damage, and functional adaptive changes in patients with cervical spondylosis and prolonged spinal cord compression

2019 ◽  
Vol 30 (1) ◽  
pp. 357-369 ◽  
Author(s):  
Ángela Bernabéu-Sanz ◽  
José Vicente Mollá-Torró ◽  
Susana López-Celada ◽  
Pedro Moreno López ◽  
Eduardo Fernández-Jover
Keyword(s):  
Spinal Cord ◽  
White Matter ◽  
Spinal Cord Compression ◽  
Brain Atrophy ◽  
Cervical Spondylosis ◽  
Cord Compression ◽  
White Matter Damage ◽  
Adaptive Changes

TGN-020 alleviates edema and inhibits astrocyte activation and glial scar formation after spinal cord compression injury in rats

Life Sciences ◽  
2019 ◽  
Vol 222 ◽  
pp. 148-157 ◽  
Author(s):  
Jian Li ◽  
Zhiqiang Jia ◽  
Wen Xu ◽  
Weidong Guo ◽  
Mingchao Zhang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Compression ◽  
Cord Compression ◽  
Glial Scar ◽  
Scar Formation ◽  
Compression Injury ◽  
Astrocyte Activation

Elevated gene expression in the red nucleus after spinal cord compression injury

Neuroreport ◽  
1992 ◽  
Vol 3 (7) ◽  
pp. 559-562 ◽  
Author(s):  
Elizabeth Theriault ◽  
Wolfram Tetzlaff ◽  
Charles H. Tator
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Spinal Cord Compression ◽  
Red Nucleus ◽  
Cord Compression ◽  
Compression Injury

scholarly journals Alleviation of chronic pain following rat spinal cord compression injury with multimodal actions of huperzine A

2013 ◽  
Vol 110 (8) ◽  
pp. E746-E755 ◽  
Author(s):  
D. Yu ◽  
D. K. Thakor ◽  
I. Han ◽  
A. E. Ropper ◽  
H. Haragopal ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Chronic Pain ◽  
Spinal Cord Compression ◽  
Cord Compression ◽  
Huperzine A ◽  
Rat Spinal Cord ◽  
Compression Injury

A new method for testing the force of clips for aneurysms or experimental spinal cord compression

1979 ◽  
Vol 51 (2) ◽  
pp. 229-233 ◽  
Author(s):  
Eugen J. Dolan ◽  
Charles H. Tator
Keyword(s):  
Spinal Cord ◽  
Early Detection ◽  
Spinal Cord Compression ◽  
Cord Compression ◽  
New Method ◽  
Content Type ◽  
Cosine Law ◽  
Fine Print

✓ A new method is described for the determination of force-distance curves for aneurysm clips. A dissecting microscope with a goniometer eyepiece was used to determine the angle between the clip blades as various forces were applied to open the clip. The cosine law was then used to calculate the force-distance curves. The method allows accurate characterization of different clips and is especially useful for the early detection of clip weakening.

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