Association of α-1-antichymotrypsin expression with the development of conformational changes of Tau protein in Alzheimer’s disease brain

Neuroscience ◽  
2022 ◽  
Author(s):  
Perla H. Horta-López ◽  
Graciela Mendoza-Franco ◽  
Fanny Rodríguez-Cruz ◽  
Francisco M. Torres-Cruz ◽  
Elizabeth Hernández-Echeagaray ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Conformational Changes ◽  
Tau Protein

scholarly journals Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer’s disease

2008 ◽  
Vol 89 (2) ◽  
pp. 81-90 ◽  
Author(s):  
Siddhartha Mondragón-Rodríguez ◽  
Gustavo Basurto-Islas ◽  
Ismael Santa-Maria ◽  
Raúl Mena ◽  
Lester I. Binder ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Conformational Changes ◽  
Tau Protein

Conformational changes and truncation of tau protein during tangle evolution in Alzheimer's disease

2003 ◽  
Vol 5 (2) ◽  
pp. 65-77 ◽  
Author(s):  
Francisco García-Sierra ◽  
Nupur Ghoshal ◽  
Bruce Quinn ◽  
Robert W. Berry ◽  
Lester I. Binder
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Conformational Changes ◽  
Tau Protein

Targeting Tau Hyperphosphorylation via Kinase Inhibition: Strategy to Address Alzheimer's Disease

2020 ◽  
Vol 20 (12) ◽  
pp. 1059-1073 ◽  
Author(s):  
Ahmad Abu Turab Naqvi ◽  
Gulam Mustafa Hasan ◽  
Md. Imtaiyaz Hassan
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Tau Protein ◽  
Glycogen Synthase ◽  
Paired Helical Filaments ◽  
Tau Hyperphosphorylation ◽  
Microtubule Stabilization ◽  
Extracellular Signal

Microtubule-associated protein tau is involved in the tubulin binding leading to microtubule stabilization in neuronal cells which is essential for stabilization of neuron cytoskeleton. The regulation of tau activity is accommodated by several kinases which phosphorylate tau protein on specific sites. In pathological conditions, abnormal activity of tau kinases such as glycogen synthase kinase-3 β (GSK3β), cyclin-dependent kinase 5 (CDK5), c-Jun N-terminal kinases (JNKs), extracellular signal-regulated kinase 1 and 2 (ERK1/2) and microtubule affinity regulating kinase (MARK) lead to tau hyperphosphorylation. Hyperphosphorylation of tau protein leads to aggregation of tau into paired helical filaments like structures which are major constituents of neurofibrillary tangles, a hallmark of Alzheimer’s disease. In this review, we discuss various tau protein kinases and their association with tau hyperphosphorylation. We also discuss various strategies and the advancements made in the area of Alzheimer's disease drug development by designing effective and specific inhibitors for such kinases using traditional in vitro/in vivo methods and state of the art in silico techniques.

scholarly journals A current view on Tau protein phosphorylation in Alzheimer's disease

2021 ◽  
Vol 69 ◽  
pp. 131-138
Author(s):  
Susanne Wegmann ◽  
Jacek Biernat ◽  
Eckhard Mandelkow
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Protein Phosphorylation ◽  
Tau Protein ◽  
Current View ◽  
A Current

Alzheimer's-disease-like changes in tau protein processing: association with aluminium accumulation in brains of renal dialysis patients

The Lancet ◽  
1994 ◽  
Vol 343 (8904) ◽  
pp. 993-997 ◽  
Author(s):  
C.R. Harrington ◽  
C.M. Wischik ◽  
F.K. McArthur ◽  
G.A. Taylor ◽  
J.A. Edwardson ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Tau Protein ◽  
Renal Dialysis ◽  
Protein Processing ◽  
Dialysis Patients ◽  
Aluminium Accumulation
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