scholarly journals The muscarinic M1 receptor modulates associative learning and memory in psychotic disorders

2020 ◽  
Vol 27 ◽  
pp. 102278
Author(s):  
Geor Bakker ◽  
Claudia Vingerhoets ◽  
Oswald J.N. Bloemen ◽  
Barbara J. Sahakian ◽  
Jan Booij ◽  
...  
Keyword(s):  
Associative Learning ◽  
Learning And Memory ◽  
Psychotic Disorders ◽  
M1 Receptor

CTRP4 ablation impairs associative learning and memory

2021 ◽  
Vol 35 (11) ◽  
Author(s):  
Dylan C. Sarver ◽  
Cheng Xu ◽  
Yi Cheng ◽  
Chantelle E. Terrillion ◽  
G. William Wong
Keyword(s):  
Associative Learning ◽  
Learning And Memory

scholarly journals Co-administration of Rauwolfia vomitoria with Gongronema latifolium or Vernonia amygdalina on spatial learning, memory, and some bio-molecules

2015 ◽  
Vol 7 (1) ◽  
pp. 82-87 ◽  
Author(s):  
Moses B Ekong ◽  
Aniekan I Peter ◽  
Ubong U Ekpene
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Psychotic Disorders ◽  
Acute Effect ◽  
Tween 20 ◽  
Spatial Learning And Memory ◽  
Vernonia Amygdalina ◽  
Male Wistar Rats ◽  
Gongronema Latifolium ◽  
Rauwolfia Vomitoria

Background: Rauwolfia vomitoria is a plant with sedative properties found useful in the management of psychotic disorders, with adverse effects being reported on its use in different brain areas.Aims and Objectives: To investigate the acute effect of combination of Rauwolfia vomitoria with either Gongronema latifolium or Vernonia amygdalina on spatial learning and memory, and some bio-molecules in rats.Materials and Methods: 24 adult male Wistar rats weighing between 220 g - 300 g were equally divided into four groups (1-4). Group 1 animals were the control treated with 0.5 ml of Tween 20. Groups 2, 3 and 4 animals were administered respectively; 150 mg/kg of R. vomitoria, a combination of 150 mg/kg of R. vomitoria and 200 mg/kg of G. latifolium, and a combination of 150 mg/kg of R. vomitoria and 200 mg/kg of V. amygdalina for seven days. On days 4-7 concurrent with treatment, spatial learning and memory test was carried out using the Morris water maze, and the animals were sacrificed twelve hours after the last treatment. Their sera were used for enzyme and other bio-molecules analysis.Results: There was no difference in spatial learning and memory. The activities of aspartate aminotrans­ferase, alanine aminotrans­ferase and alkaline phos­phatase, and the serum cholesterol and triglycerides levels were also not different compared to the control group.Conclusion: The dose and duration of administration of the extract of R. vomitoria either alone, or in combination with G. latifolium or V. amygdalina may not affect spatial learning or memory, or alter serum biomolecules.Asian Journal of Medical Sciences Vol.7(1) 2015 82-87

Associative learning and memory in a chimpanzee fetus: Learning and long-lasting memory before birth

2004 ◽  
Vol 44 (2) ◽  
pp. 116-122 ◽  
Author(s):  
Nobuyuki Kawai ◽  
Seiichi Morokuma ◽  
Masaki Tomonaga ◽  
Naoki Horimoto ◽  
Masayuki Tanaka
Keyword(s):  
Associative Learning ◽  
Learning And Memory

scholarly journals Distinct roles of the RasGAP family proteins in C. elegans associative learning and memory

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
M. Dávid Gyurkó ◽  
Péter Csermely ◽  
Csaba Sőti ◽  
Attila Steták
Keyword(s):  
Associative Learning ◽  
Learning And Memory ◽  
C Elegans

Associative learning and memory in Drosophila: beyond olfactory conditioning

2003 ◽  
Vol 64 (2) ◽  
pp. 225-238 ◽  
Author(s):  
Kathleen K. Siwicki ◽  
Lisa Ladewski
Keyword(s):  
Associative Learning ◽  
Learning And Memory ◽  
Olfactory Conditioning

Difficulties with synaptic theory of learning and memory and possible remedies

2000 ◽  
Vol 23 (4) ◽  
pp. 550-551
Author(s):  
Mikhail N. Zhadin
Keyword(s):  
Cerebral Cortex ◽  
Associative Learning ◽  
Learning And Memory ◽  
Hebbian Learning ◽  
Behavioral Responses ◽  
Learning Rules ◽  
The Brain

The absence of a clear influence of an animal's behavioral responses to Hebbian associative learning in the cerebral cortex requires some changes in the Hebbian learning rules. The participation of the brain monoaminergic systems in Hebbian associative learning is considered.

scholarly journals Dopamine D2R is Required for Hippocampal-dependent Memory and Plasticity at the CA3-CA1 Synapse

2020 ◽  
Author(s):  
Isabel Espadas ◽  
Oscar Ortiz ◽  
Patricia García-Sanz ◽  
Adrián Sanz-Magro ◽  
Samuel Alberquilla ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Associative Learning ◽  
Dopamine Receptors ◽  
Learning And Memory ◽  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Long Term Potentiation ◽  
D1 Receptor ◽  
Term Potentiation

Abstract Dopamine receptors play an important role in motivational, emotional, and motor responses. In addition, growing evidence suggests a key role of hippocampal dopamine receptors in learning and memory. It is well known that associative learning and synaptic plasticity of CA3-CA1 requires the dopamine D1 receptor (D1R). However, the specific role of the dopamine D2 receptor (D2R) on memory-related neuroplasticity processes is still undefined. Here, by using two models of D2R loss, D2R knockout mice (Drd2−/−) and mice with intrahippocampal injections of Drd2-small interfering RNA (Drd2-siRNA), we aimed to investigate how D2R is involved in learning and memory as well as in long-term potentiation of the hippocampus. Our studies revealed that the genetic inactivation of D2R impaired the spatial memory, associative learning, and the classical conditioning of eyelid responses. Similarly, deletion of D2R reduced the activity-dependent synaptic plasticity in the hippocampal CA1-CA3 synapse. Our results demonstrate the first direct evidence that D2R is essential in behaving mice for trace eye blink conditioning and associated changes in hippocampal synaptic strength. Taken together, these results indicate a key role of D2R in regulating hippocampal plasticity changes and, in consequence, acquisition and consolidation of spatial and associative forms of memory.

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