scholarly journals Evoked and intrinsic brain network dynamics in children with autism spectrum disorder

2020 ◽  
Vol 28 ◽  
pp. 102396
Author(s):  
Lauren Kupis ◽  
Celia Romero ◽  
Bryce Dirks ◽  
Stephanie Hoang ◽  
Meaghan V. Parladé ◽  
...  
2016 ◽  
Vol 234 (12) ◽  
pp. 3425-3431 ◽  
Author(s):  
Evie Malaia ◽  
Erik Bates ◽  
Benjamin Seitzman ◽  
Katherine Coppess

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Ke Zeng ◽  
Jiannan Kang ◽  
Gaoxiang Ouyang ◽  
Jingqing Li ◽  
Junxia Han ◽  
...  

2020 ◽  
Vol 4 (4) ◽  
pp. 1219-1234 ◽  
Author(s):  
Emily Marshall ◽  
Jason S. Nomi ◽  
Bryce Dirks ◽  
Celia Romero ◽  
Lauren Kupis ◽  
...  

Brain connectivity studies of autism spectrum disorder (ASD) have historically relied on static measures of functional connectivity. Recent work has focused on identifying transient configurations of brain activity, yet several open questions remain regarding the nature of specific brain network dynamics in ASD. We used a dynamic coactivation pattern (CAP) approach to investigate the salience/midcingulo-insular (M-CIN) network, a locus of dysfunction in ASD, in a large multisite resting-state fMRI dataset collected from 172 children (ages 6–13 years; n = 75 ASD; n = 138 male). Following brain parcellation by using independent component analysis, dynamic CAP analyses were conducted and k-means clustering was used to determine transient activation patterns of the M-CIN. The frequency of occurrence of different dynamic CAP brain states was then compared between children with ASD and typically developing (TD) children. Dynamic brain configurations characterized by coactivation of the M-CIN with central executive/lateral fronto-parietal and default mode/medial fronto-parietal networks appeared less frequently in children with ASD compared with TD children. This study highlights the utility of time-varying approaches for studying altered M-CIN function in prevalent neurodevelopmental disorders. We speculate that altered M-CIN dynamics in ASD may underlie the inflexible behaviors commonly observed in children with the disorder.


2015 ◽  
Vol 12 (1) ◽  
pp. 37 ◽  
Author(s):  
Sun-Young Kim ◽  
Uk-Su Choi ◽  
Sung-Yeon Park ◽  
Se-Hong Oh ◽  
Hyo-Woon Yoon ◽  
...  

2020 ◽  
Vol 29 (2) ◽  
pp. 586-596 ◽  
Author(s):  
Kaitlyn A. Clarke ◽  
Diane L. Williams

Purpose The aim of this research study was to examine common practices of speech-language pathologists (SLPs) who work with children with autism spectrum disorder (ASD) with respect to whether or not SLPs consider processing differences in ASD or the effects of input during their instruction. Method Following a qualitative research method, how SLPs instruct and present augmentative and alternative communication systems to individuals with ASD, their rationale for method selection, and their perception of the efficacy of selected interventions were probed. Semistructured interviews were conducted as part of an in-depth case report with content analysis. Results Based on completed interviews, 4 primary themes were identified: (a) instructional method , (b) input provided , (c) decision-making process , and (d) perceived efficacy of treatment . Additionally, one secondary theme, training and education received , was identified . Conclusions Clinicians reported making decisions based on the needs of the child; however, they also reported making decisions based on the diagnostic category that characterized the child (i.e., ASD). The use of modeling when teaching augmentative and alternative communication to individuals with ASD emerged as a theme, but variations in the method of modeling were noted. SLPs did not report regularly considering processing differences in ASD, nor did they consider the effects of input during instruction.


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