M.P.3.06 Quantification of upper limb activity in non ambulant boys with Duchenne muscular dystrophy using accelerometry: A proof-of-concept study

2009 ◽  
Vol 19 (8-9) ◽  
pp. 602-603
Author(s):  
L. Servais ◽  
A. Canal ◽  
J.Y. Hogrel ◽  
T. Voit
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Upper Limb ◽  
Proof Of Concept ◽  
Concept Study

P.315Src tyrosine kinase as a drug target in Duchenne muscular dystrophy: a proof-of-concept study in the exercised mdx mouse

2019 ◽  
Vol 29 ◽  
pp. S159
Author(s):  
F. Sanarica ◽  
B. Boccanegra ◽  
P. Mantuano ◽  
O. Cappellari ◽  
M. De Bellis ◽  
...  
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Tyrosine Kinase ◽  
Drug Target ◽  
Mdx Mouse ◽  
Proof Of Concept ◽  
Concept Study

scholarly journals Improved Muscle Function in Duchenne Muscular Dystrophy through L-Arginine and Metformin: An Investigator-Initiated, Open-Label, Single-Center, Proof-Of-Concept-Study

PLoS ONE ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. e0147634 ◽  
Author(s):  
Patricia Hafner ◽  
Ulrike Bonati ◽  
Beat Erne ◽  
Maurice Schmid ◽  
Daniela Rubino ◽  
...  
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Muscle Function ◽  
Proof Of Concept ◽  
Single Center ◽  
Open Label ◽  
Concept Study

scholarly journals Prosthesis embodiment and attenuation of prosthetic touch in upper limb amputees – A proof-of-concept study

2021 ◽  
Vol 88 ◽  
pp. 103073
Author(s):  
Antonia Fritsch ◽  
Bigna Lenggenhager ◽  
Robin Bekrater-Bodmann
Keyword(s):  
Upper Limb ◽  
Proof Of Concept ◽  
Concept Study

Performance of the Upper Limb Module—A Reliable and Valid Evaluation for Chinese Patients with Duchenne Muscular Dystrophy

2020 ◽  
Author(s):  
Yuen Yee Alice Chiu ◽  
Chun Wai Lo ◽  
Chi Kuk Connie Hui ◽  
Wai Chong Susanna Choi ◽  
So Lun Lee ◽  
...  
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Upper Limb ◽  
Forced Vital Capacity ◽  
Motor Performance ◽  
Vital Capacity ◽  
High Reliability ◽  
Reliability And Validity ◽  
Chinese Patients ◽  
Rater Reliability

Abstract Background Duchenne muscular dystrophy is a genetic disease leading to progressive muscle weakness and degeneration. Effective assessment tool is needed to allow monitoring of progress to guide the management. This study assessed the reliability and validity of the Performance of Upper Limb (PUL) Module when used in patients with Duchenne Muscular Dystrophy (DMD). MethodsTotal thirty-three Chinese DMD patients were included. Twenty-five video-recorded PUL Module version 1.3 assessments were performed for the recruited patients with three raters evaluated the same recorded video for inter-rater reliability and evaluated the same performance one month later for intra-rater reliability. Construct validity was assessed correlating the PUL Module scores with the patients’ age, their forced vital capacity (N=25) and their Hammersmith motor scale scores (N=25) performed on the same day. ResultsThe intra-rater and inter-rater reliability (ICC 0.92 - 0.99), internal consistency (Cronbach’s alpha 0.97 - 0.99) and known groups validity (AUC 0.97) of PUL module were excellent. PUL was negatively correlated with age (r = -0.912), and positively correlated with the forced vital capacity (r = 0.87) and the Hammersmith motor scale (r = 0.84). The findings confirm the high reliability and validity of PUL module, and its high clinical relevancy in monitoring the deteriorating upper limb motor performance that strongly correlated with the lung function and generalized motor performance as age increased in DMD. ConclusionThis first study of PUL module in Chinese patients with DMD confirmed that it is a reliable valid tool to monitor clinical progress and outcome for DMD.

scholarly journals Upper limb function in Duchenne muscular dystrophy: 24 month longitudinal data

PLoS ONE ◽  
2018 ◽  
Vol 13 (6) ◽  
pp. e0199223 ◽  
Author(s):  
Marika Pane ◽  
Giorgia Coratti ◽  
Claudia Brogna ◽  
Elena Stacy Mazzone ◽  
Anna Mayhew ◽  
...  
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Longitudinal Data ◽  
Upper Limb ◽  
Limb Function ◽  
Upper Limb Function

Manual ability and upper limb performance in nonambulatory stage of Duchenne muscular dystrophy

2020 ◽  
Vol 27 (6) ◽  
pp. 304-309
Author(s):  
G. Demir ◽  
N. Bulut ◽  
Ö. Yılmaz ◽  
A. Karaduman ◽  
İ. Alemdaroğlu-Gürbüz
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Upper Limb
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