White matter lesions predict cognitive dysfunction in patients with essential tremor

2015 ◽  
Vol 21 (1) ◽  
pp. 33-38
Author(s):  
Abdulkadir Koçer ◽  
Münevver Okay ◽  
Buse Hasırcı ◽  
Dilek Ağırcan ◽  
Buket Şanlısoy
Keyword(s):  
White Matter ◽  
Essential Tremor ◽  
Cognitive Dysfunction ◽  
White Matter Lesions

Association between White Matter Lesions and Non-Motor Symptoms in Parkinson Disease

2018 ◽  
Vol 18 (2-3) ◽  
pp. 127-132 ◽  
Author(s):  
Jeong-Yoon Lee ◽  
Ji Sun Kim ◽  
Wooyoung Jang ◽  
Jinse Park ◽  
Eungseok Oh ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
White Matter ◽  
Parkinson Disease ◽  
Cognitive Dysfunction ◽  
Rating Scale ◽  
White Matter Lesions ◽  
Motor Dysfunction ◽  
Motor Symptoms ◽  
Non Motor Symptoms

Background: There are only few studies exploring the relationship between white matter lesions (WMLs) and non-motor symptoms in Parkinson disease (PD). This study aimed to investigate the association between WMLs and the severity of non-motor symptoms in PD. Methods: The severity of motor dysfunction, cognitive impairment, and non-motor symptoms was assessed by various scales in 105 PD patients. We used a visual semiquantitative rating scale and divided the subjects into four groups: no, mild, moderate, and severe WMLs. We compared the means of all scores between the four groups and analyzed the association between the severity of WMLs and the specific domain of non-motor symptoms. Results: The non-motor symptoms as assessed by the Non-Motor Symptoms Scale, Parkinson’s Disease Questionnaire (PDQ-39), Parkinson’s Disease Sleep Scale, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Neuropsychiatric Inventory (NPI), and Parkinson Fatigue Scale (PFS) were significantly worse in the patients with moderate and severe WMLs than in those without WMLs. Compared with the no WML group, the scores for motor dysfunction were significantly higher in the mild, moderate, and severe WML groups. The scores for cognitive dysfunction were significantly higher in the patients with severe WMLs than in those without WMLs. The severity of WMLs showed linear associations with PFS, BDI, BAI, NPI, and PDQ-39 scores. The severity of WMLs also correlated linearly with scores for motor and cognitive dysfunction. Conclusions: Among the non-motor symptoms, fatigue, depression, anxiety, and quality of life were significantly affected by WMLs in PD. Confirmation of the possible role of WMLs in non-motor symptoms associated with PD in a prospective manner may be crucial not only for understanding non-motor symptoms but also for the development of treatment strategies.

scholarly journals An Assessment of the Relationship between Structural and Functional Imaging of Cerebrovascular Disease and Cognition-Related Fibers

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Xiaoping Tang ◽  
Xinlan Xiao ◽  
Jianhua Yin ◽  
Ting Yang ◽  
Bingliang Zeng
Keyword(s):  
Cognitive Impairment ◽  
White Matter ◽  
Cerebrovascular Disease ◽  
Cognitive Dysfunction ◽  
Functional Imaging ◽  
Small Vessel Disease ◽  
White Matter Lesions ◽  
Cerebral Small Vessel Disease ◽  
Vessel Disease ◽  
The Relationship

In order to assess the relationship between structural and functional imaging of cerebrovascular disease and cognition-related fibers, this paper chooses a total of 120 patients who underwent cerebral small vessel disease (CSVD) treatment at a designated hospital by this study from June 2013 to June 2018 and divides them into 3 groups according to the random number table method: vascular dementia (VaD) group, vascular cognitive impairment no dementia (VCIND) group, and noncognition impairment (NCI) group with 40 cases of patients in each group. Cognitive function measurement and imaging examination were performed for these 3 groups of patients, and the observation indicators of cognitive state examination (CSE), mental assessment scale (MAS), clock drawing test (CDT), adult intelligence scale (AIS), frontal assessment battery (FAB), verbal fluency test (VFT), trail making test (TMT), cognitive index (CI), white matter lesions (WML), third ventricle width (TVW), and frontal horn index (FHI) were tested, respectively. The results shows that the average scores of CSE, MAS, AIS, and VFT in the VaD and VCIND group are lower than those of the NCI group and the differences are statistically significant (P<0.05); the average scores of FAB, TMT, and CI in the VaD group are higher than those of the VCIND group and the differences are also statistically significant (P<0.05); the average scores of FHI and TVW in the VaD group are lower than those of the VCIND and NCI group with statistically significant differences (P<0.05); the average scores of WML, CDT, and AIS in the VaD group are higher than those of the VCIND and NCI group with statistically significant differences (P<0.05). Therefore, it is believed that the structural and functional imaging features of cerebrovascular disease are closely related to cognition-related fibers, and the incidence of white matter lesions is closely related to the degree of lesions and cognitive dysfunction of cerebral small vessel disease, in which a major risk factor for cognitive dysfunction in patients with small blood vessels is the severity of white matter lesions; brain imaging and neuropsychiatric function assessment can better understand the relationship between cerebrovascular disease and cognitive impairment. The results of this study provide a reference for the further research studies on the relationship between structural and functional imaging of cerebrovascular disease and cognition-related fibers.

Brain white matter lesions and postoperative cognitive dysfunction: a review

2019 ◽  
Vol 33 (2) ◽  
pp. 336-340 ◽  
Author(s):  
Shinichi Nakao ◽  
Tomohisa Yamamoto ◽  
Seishi Kimura ◽  
Takashi Mino ◽  
Tatsushige Iwamoto
Keyword(s):  
White Matter ◽  
Cognitive Dysfunction ◽  
Postoperative Cognitive Dysfunction ◽  
White Matter Lesions ◽  
Brain White Matter

scholarly journals Author Correction: White matter microstructural changes are related to cognitive dysfunction in essential tremor

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Julián Benito-León ◽  
Virginia Mato-Abad ◽  
Elan D. Louis ◽  
Juan Antonio Hernández-Tamames ◽  
Juan Álvarez-Linera ◽  
...  
Keyword(s):  
White Matter ◽  
Essential Tremor ◽  
Cognitive Dysfunction ◽  
Microstructural Changes

Cognitive Functioning and Magnetic Resonance Imaging in Chronic Fatigue

1995 ◽  
Vol 167 (1) ◽  
pp. 86-94 ◽  
Author(s):  
Helen Cope ◽  
Amanda Pernet ◽  
Brian Kendall ◽  
Anthony David
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Cognitive Dysfunction ◽  
White Matter Lesions ◽  
Chronic Fatigue ◽  
Depressive Illness ◽  
Cerebral White Matter ◽  
Resonance Imaging ◽  
Fatigue Syndrome

BackgroundThis study examines whether cognitive dysfunction in chronic fatigue may be accounted for by depression and anxiety or is due to brain pathology evident on magnetic resonance imaging (MRI).MethodTwenty-six subjects with chronic fatigue, with and without coexisting depression, and 18 age-matched normal controls were recruited from primary care following a presumed viral illness six months previously. Comparison was made with 13 psychiatric controls with depressive illness on standardised cognitive tests. MRI determined the presence of cerebral white-matter lesions.ResultsNo substantial differences in performance were shown between subjects with chronic fatigue, most of whom met the criteria for chronic fatigue syndrome, and controls. Subjective cognitive dysfunction increased with psychopathology. White-matter lesions were found in a minority from all groups. Improvement in fatigue and depression coincided with improved performance on cognitive measures.ConclusionsSubjective complaints of cognitive impairment are a prominent feature of chronic fatigue, but objective cognitive and MRI abnormalities are not. Such complaints probably reflect psychopathology rather than a post-viral process.

scholarly journals Cerebral white matter lesions and perceived cognitive dysfunction: the role of pregnancy

2014 ◽  
Vol 211 (3) ◽  
pp. 257.e1-257.e5 ◽  
Author(s):  
Ineke R. Postma ◽  
Jan Cees de Groot ◽  
Annet M. Aukes ◽  
Jan G. Aarnoudse ◽  
Gerda G. Zeeman
Keyword(s):  
White Matter ◽  
Cognitive Dysfunction ◽  
White Matter Lesions ◽  
Cerebral White Matter ◽  
Cerebral White Matter Lesions

scholarly journals Cerebral white matter lesions and subjective cognitive dysfunction: The Rotterdam Scan Study

Neurology ◽  
2001 ◽  
Vol 56 (11) ◽  
pp. 1539-1545 ◽  
Author(s):  
J.C. de Groot ◽  
F.-E. de Leeuw ◽  
M. Oudkerk ◽  
A. Hofman ◽  
J. Jolles ◽  
...  
Keyword(s):  
White Matter ◽  
Cognitive Dysfunction ◽  
White Matter Lesions ◽  
Cerebral White Matter ◽  
Cerebral White Matter Lesions

scholarly journals White matter microstructural changes are related to cognitive dysfunction in essential tremor

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Julián Benito-León ◽  
Virginia Mato-Abad ◽  
Elan D. Louis ◽  
Juan Antonio Hernández-Tamames ◽  
Juan Álvarez-Linera ◽  
...  
Keyword(s):  
White Matter ◽  
Essential Tremor ◽  
Cognitive Dysfunction ◽  
Microstructural Changes

‘Essential Tremor’ Phenotype in FMR1 Premutation/Gray Zone Sibling Series: Exploring Possible Genetic Modifiers

2021 ◽  
pp. 1-8
Author(s):  
Danuta Z. Loesch ◽  
David L. Duffy ◽  
Nicholas G. Martin ◽  
Flora Tassone ◽  
Anna Atkinson ◽  
...  
Keyword(s):  
White Matter ◽  
Essential Tremor ◽  
Fragile X ◽  
White Matter Lesions ◽  
Risk Scores ◽  
Gait Ataxia ◽  
Gray Zone ◽  
Fmr1 Premutation ◽  
Kinetic Tremor ◽  
Study Results

Abstract Fragile X-associated tremor/ataxia syndrome (FXTAS) occurs in carriers of fragile X mental retardation 1 (FMR1) X-linked small CGG expansion (gray zone [GZ] and premutation [PM]) alleles, containing 41–200 repeats. Major features comprise kinetic tremor, gait ataxia, cognitive decline and cerebellar peduncular white matter lesions, but atypical/incomplete FXTAS may occur. We explored the possibility of polygenic effects modifying the FXTAS spectrum phenotypes. We used three motor scales and selected cognitive tests in a series of three males and three females from a single sibship carrying PM or GZ alleles (44 to 75 repeats). The molecular profiles from these siblings were determined by genomewide association study with single-nucleotide polymorphism (SNP) genotyping by Illumina Global Screening Array. Nonparametric linkage analysis was applied and Parkinson’s disease (PD) polygenic risk scores (PRSs) were calculated for all the siblings, based on 107 known risk variants. All male and female siblings manifested similar kinetic tremor phenotypes. In contrast to FXTAS, they showed negligible gait ataxia, and few white matter lesions on MRI. Cognitive functioning was unaffected. Suggestive evidence of linkage to a broad region of the short arm of chromosome 10 was obtained, and median PD PRS for the sibship fell within the top 30% of a sample of over 500,000 UK and Australian controls. The genomewide study results are suggestive of modifying effects of genetic risk loci linked to PD, on the neurological phenotype of FMR1-CGG small expansion carriers, resulting in an oligosymptomatic kinetic tremor seen in FXTAS spectrum, but also consistent with essential tremor.

Sign in / Sign up

Export Citation Format

Share Document