Age-dependent change of RFRP-3 neuron numbers and innervation in female mice

Neuropeptides ◽  
2021 ◽  
pp. 102224
Author(s):  
Eleni Angelopoulou ◽  
Andries Kalsbeek ◽  
Valérie Simonneaux
Keyword(s):  
Female Mice ◽  
Dependent Change ◽  
Age Dependent

scholarly journals Age-Dependent Change of Tonic Immobility Response in Chicks of a Native Japanese Chicken breed, Tosa-Jidori

2013 ◽  
Vol 50 (4) ◽  
pp. 321-325 ◽  
Author(s):  
Eriko Nakasai ◽  
Hiroshi Tanizawa ◽  
Minani Takawaki ◽  
Kouichi Yanagita ◽  
Shin-ichi Kawakami ◽  
...  
Keyword(s):  
Tonic Immobility ◽  
Chicken Breed ◽  
Immobility Response ◽  
Dependent Change ◽  
Age Dependent

scholarly journals Enhanced Expression of NR2B Subunits of NMDA Receptors in the Inherited Glaucomatous DBA/2J Mouse Retina

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Ling-Dan Dong ◽  
Jie Chen ◽  
Fang Li ◽  
Feng Gao ◽  
Jihong Wu ◽  
...  
Keyword(s):  
Secondary Glaucoma ◽  
Mouse Retina ◽  
Retinal Ganglion ◽  
Protein Levels ◽  
Dependent Change ◽  
Blot Technique ◽  
Elevated Intraocular Pressure ◽  
Age Dependent ◽  
Enhanced Expression ◽  
Nmdar Subunits

DBA/2J mouse has been used as a model for spontaneous secondary glaucoma. Here, we investigated changes in expression of NMDA receptor (NMDAR) subunits and Cdk5/p35/NMDAR signaling in retinas of DBA/2J mice using Western blot technique. The protein levels of NR1 and NR2A subunits in retinas of DBA/2J mice at all ages (6–12 months) were not different from those in age-matched C57BL/6 mice. In contrast, the protein levels of NR2B subunits, in addition to age-dependent change, significantly increased with elevated intraocular pressure (IOP) in DBA/2J mice at 6 and 9 months as compared with age-matched controls. Moreover, expression of Cdk5, p35 and ratio of p-NR2AS1232/NR2A progressively increased with time in both strains, suggestive of activated Cdk5/p35 signaling pathway. However, the changes in these proteins were in the same levels in both strain mice, except a significant increase of p35 proteins at 6 months in DBA/2J mice. Meanwhile, the protein levels of Brn-3a, a retinal ganglion cell (RGC) maker, remarkably decreased at 9–12 months in DBA/2J mice, which was in parallel with the changes of NR2B expression. Our results suggest that elevated IOP-induced increase in expression of NR2B subunits of NMDARs may be involved in RGC degeneration of DBA/2J mice.

Age-dependent change in sensitivity of oestrogen-induced uterine cell proliferation of mice, estimated by incorporation of [125I]iododeoxyuridine

1985 ◽  
Vol 23 (6) ◽  
pp. 1037-1041 ◽  
Author(s):  
N. Terada ◽  
T. Yamane ◽  
Y. Ogasawara ◽  
K. Matsumoto ◽  
Y. Kitamura
Keyword(s):  
Cell Proliferation ◽  
Dependent Change ◽  
Age Dependent

Age-Dependent Replication of Respiratory Syncytial Virus in the Cotton Rat

2002 ◽  
Vol 227 (9) ◽  
pp. 799-802 ◽  
Author(s):  
Spencer J. Curtis ◽  
Martin G. Ottolini ◽  
David D. Porter ◽  
Gregory A. Prince
Keyword(s):  
Respiratory Syncytial Virus ◽  
Age Groups ◽  
Fold Increase ◽  
The Elderly ◽  
Geriatric Population ◽  
Cotton Rat ◽  
Dependent Change ◽  
Age Dependent ◽  
Syncytial Virus ◽  
Viral Titers

Despite the documented disease burden of respiratory syncytial virus (RSV) in the elderly, little is known about the underlying risk factors or pathogenesis of RSV in a geriatric population. This report describes an age-dependent change of RSV clearance in the lung and nose of the cotton rat. Six days postinfection with RSV, lung and nose viral titers were significantly higher in all older age groups as compared with 4- to 6-week old cotton rats (P < 0.05). When comparing the 4- to 6-week old animals to the 15- to 16-month old animals 6 days postinfection, there was over an 800- and 100-fold increase in lung and nose viral titers, respectively. The cotton rat may prove to be a useful model in eliciting mechanisms of severe RSV disease in the elderly.

Age-dependent change in the 3D structure of cortical porosity at the human femoral midshaft

Bone ◽  
2007 ◽  
Vol 40 (4) ◽  
pp. 957-965 ◽  
Author(s):  
David M.L. Cooper ◽  
C. David L. Thomas ◽  
John G. Clement ◽  
Andrei L. Turinsky ◽  
Christoph W. Sensen ◽  
...  
Keyword(s):  
3D Structure ◽  
Cortical Porosity ◽  
Dependent Change ◽  
Age Dependent

Age-dependent differences in nicotine reward and withdrawal in female mice

2008 ◽  
Vol 198 (2) ◽  
pp. 201-210 ◽  
Author(s):  
D. Kota ◽  
B.R. Martin ◽  
M. I. Damaj
Keyword(s):  
Female Mice ◽  
Age Dependent

Age‐dependent responses to 2‐acetylaminofluorene in BALB/c female mice

1987 ◽  
Vol 22 (2) ◽  
pp. 113-129 ◽  
Author(s):  
David L. Greenman ◽  
Arlis Boothe ◽  
Ralph Kodell
Keyword(s):  
Female Mice ◽  
Age Dependent

scholarly journals Female Mice Haploinsufficient for an Inactivated Androgen Receptor (AR) Exhibit Age-Dependent Defects That Resemble the AR Null Phenotype of Dysfunctional Late Follicle Development, Ovulation, and Fertility

Endocrinology ◽  
2007 ◽  
Vol 148 (8) ◽  
pp. 3674-3684 ◽  
Author(s):  
K. A. Walters ◽  
C. M. Allan ◽  
M. Jimenez ◽  
P. R. Lim ◽  
R. A. Davey ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Ovarian Function ◽  
Gene Dosage ◽  
Early Embryo ◽  
Ovulation Rate ◽  
Corpora Lutea ◽  
Cell Stage ◽  
Gene Dosage Effect ◽  
Female Mice ◽  
Age Dependent

The role of classical genomic androgen receptor (AR) mediated actions in female reproductive physiology remains unclear. Female mice homozygous for an in-frame deletion of exon 3 of the Ar (AR−/−) were subfertile, exhibiting delayed production of their first litter (AR+/+ = 22 d vs. AR−/− = 61 d, P &lt; 0.05) and producing 60% fewer pups/litter (AR+/+: 8.1 ± 0.4 vs. AR−/−: 3.2 ± 0.9, P &lt; 0.01). Heterozygous females (AR+/−) exhibited an age-dependent 55% reduction (P &lt; 0.01) in pups per litter, evident from 6 months of age (P &lt; 0.05), compared with AR+/+, indicating a significant gene dosage effect on female fertility. Ovulation was defective with a significant reduction in corpora lutea numbers (48–79%, P &lt; 0.01) in 10- to 12- and 26-wk-old AR+/− and AR−/− females and a 57% reduction in oocytes recovered from naturally mated AR−/− females (AR+/+: 9.8 ± 1.0 vs. AR−/−: 4.2 ± 1.2, P &lt; 0.01); however, early embryo development to the two-cell stage was unaltered. The delay in first litter, reduction in natural ovulation rate, and aromatase expression in AR+/− and AR−/− ovaries, coupled with the restored ovulation rate by gonadotropin hyperstimulation in AR−/− females, suggest aberrant gonadotropin regulation. A 2.7-fold increase (AR+/+: 35.4 ± 13.4 vs. AR−/−: 93.9 ± 6.1, P &lt; 0.01) in morphologically unhealthy antral follicles demonstrated deficiencies in late follicular development, although growing follicle populations and growth rates were unaltered. This novel model reveals that classical genomic AR action is critical for normal ovarian function, although not for follicle depletion and that haploinsufficiency for an inactivated AR may contribute to a premature reduction in female fecundity.

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