P1.79. The impact of surgical intervention on salivary gland function and health-related quality of life in head and neck cancer patients

Trismus is a common symptom in patients with head and neck cancer that affects many aspects of daily life negatively. The aim of this study was to investigate the impact of structured exercise with the jaw-mobilizing device TheraBite on trismus, trismus-related symptomatology, and health-related quality of life (HRQL) in patients with head and neck cancer. Fifteen patients with trismus (maximum interincisal opening [MIO] ≤35 mm) after oncologic treatment for head and neck cancer, underwent a 10-week exercise program with the TheraBite device and were followed regularly. Time between oncologic treatment and start of TheraBite exercise ranged from 0.7 to 14.8 years (average 6.2 years). MIO, trismus-related symptoms, and HRQL was assessed before and after exercise and after 6 months. A significant improvement in MIO was observed post-exercise (3.5 mm, 15.3%, p = 0.0002) and after 6-month of follow-up (4.7 mm, 22.1%, p = 0.0029). A statistically significant correlation was found between increased MIO and fewer trismus-related symptoms. In conclusion, exercise with TheraBite improved MIO and trismus-related symptoms in patients with trismus secondary to head and neck cancer. Structured exercise with the jaw-mobilizing device seems to be beneficial for patients with trismus independent of time since oncologic treatment.

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Scintigraphic Assessment of Late Parotid Gland Function after Radiotherapy for Head and Neck Cancer and Its Correlation with Health-Related Quality of Life Measurement

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2010.07.1030 ◽

2010 ◽

Vol 78 (3) ◽

pp. S438

Author(s):

W. Chen ◽

C. Lai ◽

S. Lee ◽

H. Chen ◽

M. Chen

Keyword(s):

Quality Of Life ◽

Head And Neck Cancer ◽

Health Related Quality ◽

Life Measurement ◽

Related Quality ◽

Health Related ◽

Gland Function ◽

Quality Of Life Measurement ◽

Scintigraphic Assessment

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Impact of sialendoscopy on improving health related quality of life in patients suffering from radioiodineinduced xerostomia

Nuklearmedizin ◽

10.3413/nukmed-0964-18-03 ◽

2018 ◽

Vol 57 (04) ◽

pp. 160-167 ◽

Cited By ~ 2

Author(s):

Sabine Haufe ◽

Ralph Hohenberger ◽

Matti Hein ◽

Clemens Kratochwil ◽

Hendrik Rathke ◽

...

Keyword(s):

Quality Of Life ◽

Salivary Gland ◽

Common Side Effect ◽

Control Group ◽

Health Related Quality ◽

Patient Reported ◽

Related Quality ◽

Health Related ◽

The Impact

Summary Introduction: Xerostomia following radioiodine therapy (RIT) in patients suffering from differentiated thyroid cancer is a common side effect in 2 % to 67 % of patients treated with radioiodine (I-131). In order to evaluate the impact of sialendoscopy on health related quality of life (HRQOL) in patients suffering from therapy induced sialadenitis and xerostomia, we analyzed findings from two dedicated questionnaires (Xerostomy Questionnaire XQ and Xerostomy Inventory XI) in patients before and three months after sialendoscopy. Procedures: In total, 12 patients suffering from differentiated thyroid carcinoma (10 women and 2 men) were evaluated. All patients had experienced conservative management. Patients were offered a sialendoscopy procedure if no major contradictions were present. Patients who denied the procedure formed the control group. Pre- and (three months) postoperative HRQOL was measured with the Patient Reported Outcome Measures (PROM) Xerostomia Questionnaire (XQ) and the Xerostomia Inventory (XI), as well as by a pre- and post-interventional salivary gland scintigram. Patients were graded according to their sialendoscopical findings. Results: Interventional group presented with significant improvements in HRQOL measurements regarding XQ and XI-scores three months postoperatively. Control group showed no significant changes in the XQ or the XI scores. Number of RIT and cumulative activity of I-131 did not correlate with higher disease grade in regards to sialendoscopical findings nor did it correlate with higher XQand XI scores. Pre- and post-interventional salivary gland scintigram stated that parotid glands are more severely damaged than submandibular glands (SMG), but no significant scintigraphically changes could be detected after sialendoscopy. Conclusion: Sialendoscopy in patients suffering from therapy induced sialadenitis and xerostomia seems to be beneficial when evaluating the impact on HRQOL. Functional parameters measured by salivary gland scintigram did not show significant changes in post-interventional scintigrams.

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Changes in health related quality of life in women and men undergoing radiation treatment for head and neck cancer and the impact of smoking status in the radiation treatment period

European Journal of Oncology Nursing ◽

10.1016/j.ejon.2014.04.003 ◽

2014 ◽

Vol 18 (4) ◽

pp. 339-346 ◽

Cited By ~ 10

Author(s):

Helen Egestad ◽

Nina Emaus

Keyword(s):

Quality Of Life ◽

Head And Neck Cancer ◽

Head And Neck ◽

Radiation Treatment ◽

Smoking Status ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

The Impact

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Photobiomodulation reduces the impact of radiotherapy on oral health-related quality of life due to mucositis-related symptoms in head and neck cancer patients

Lasers in Medical Science ◽

10.1007/s10103-020-03167-z ◽

2020 ◽

Author(s):

Allisson Filipe Lopes Martins ◽

Marília Oliveira Morais ◽

Sebastião Silvério de Sousa-Neto ◽

Ana Paula Gonçalves de Jesus ◽

Tulio Eduardo Nogueira ◽

...

Keyword(s):

Quality Of Life ◽

Head And Neck Cancer ◽

Oral Health ◽

Head And Neck ◽

Cancer Patients ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

The Impact

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Are Salivary Gland Ultrasonography Scores Associated with Salivary Flow Rates and Oral Health-related Quality of Life in Sjögren Syndrome?

The Journal of Rheumatology ◽

10.3899/jrheum.190849 ◽

2020 ◽

Vol 47 (12) ◽

pp. 1774-1779

Author(s):

Yasemin Yalcinkaya ◽

Gonca Mumcu ◽

Filiz Türe Özdemir ◽

Ramazan Esad Kuruş ◽

Ali Uğur Ünal ◽

...

Keyword(s):

Quality Of Life ◽

Salivary Gland ◽

Oral Health ◽

Flow Rate ◽

Salivary Flow ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

Gland Function

Objective.Major salivary gland ultrasonography (SGUS) is a widely used imaging technique to evaluate salivary gland involvement in primary Sjögren syndrome (pSS). The aim of this study was to evaluate the relationship between SGUS, salivary flow rate (SFR) as an objective measure of the gland function, and oral health-related quality of life (OHRQOL) as a patient-reported outcome measure (PROM) in a pSS cohort.Methods.Sixty-six patients with pSS were examined by SGUS according to Hocevar and Milic scoring systems. Patients with inhomogeneity/hypoechoic areas with scores ≥ 2 in parotid and submandibular glands were classified separately as “severe glandular involvement.” Further, oral health, SFR, and Oral Health Impact Profile-14 (OHIP-14) for OHRQOL were assessed.ResultsBoth total Hocevar and Milic scores were higher in 21 pSS patients with low unstimulated whole salivary flow rate (U-WSFR) than 45 pSS patients without low U-WSFR (P = 0.001 and P < 0.0001, respectively). Increased scores of homogeneity, hypoechoic areas and glandular border visibility were observed in patients with low U-WSFR (P < 0.05). Among these variables, homogeneity score was found to be an independent risk factor for low U-WSFR in pSS according to logistic regression analysis (OR 1.586, P = 0.001). Moreover, a higher OHIP-14 score was observed in severe parotid involvement compared to nonsevere cases (23.26 ± 21.19 vs 8.32 ± 13.82, P = 0.004).Conclusion.High Milic and Hocevar SGUS scores are associated with reduced SFR and poor OHRQOL as a PROM. The inhomogeneity component of the SGUS score is associated with low U-WSFR and is an indicator of severely affected gland function.

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