Acquired Optic Nerve and Peripapillary Pits in Pathologic Myopia

Abstract This study explored morphology and microcirculation changes of optic nerve head (ONH) in simple high myopia(SHM) and pathologic myopia(PM), in order to evaluate and identify ONH changes in the development of PM. We divided 193 right eyes of 193 patients into SHM and PM according to the retinopathy. We found that ONH is one of the earliest pathological changes in myopia, and its morphology changes were also the most obvious. PM is closely linked to the reduction of choroidal perfusion and structural changes of ONH. Microcirculation showed a significant priority changes in myopia. Further research should address whether these fndings are associated with future disease development in highly myopic eyes.

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Imaging Retrobulbar Subarachnoid Space around Optic Nerve by Swept-Source Optical Coherence Tomography in Eyes with Pathologic Myopia

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.11-8597 ◽

2011 ◽

Vol 52 (13) ◽

pp. 9644 ◽

Cited By ~ 50

Author(s):

Kyoko Ohno-Matsui ◽

Masahiro Akiba ◽

Muka Moriyama ◽

Tatsuro Ishibashi ◽

Takashi Tokoro ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Optic Nerve ◽

Subarachnoid Space ◽

Pathologic Myopia ◽

Optical Coherence ◽

Swept Source

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Decision letter for "The Effect of Optic Nerve Section on Form Deprivation Myopia in the Guinea Pig"

10.1002/cne.24961/v1/decision1 ◽

2020 ◽

Keyword(s):

Optic Nerve ◽

Guinea Pig ◽

Nerve Section

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Oligodendrocytes in Developing Hameter Cerebral Cortex

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100090610 ◽

1976 ◽

Vol 34 ◽

pp. 126-127

Author(s):

MB. Tank Buschmann

Keyword(s):

Cerebral Cortex ◽

Optic Nerve ◽

Frontal Cortex ◽

Osmium Tetroxide ◽

Sodium Cacodylate Buffer ◽

Sodium Cacodylate ◽

Tissue Samples ◽

Cacodylate Buffer ◽

Layer V ◽

Adult Hamster

Development of oligodendrocytes in rat corpus callosum was described as a sequential change in cytoplasmic density which progressed from light to medium to dark (1). In rat optic nerve, changes in cytoplasmic density were not observed, but significant changes in morphology occurred just prior to and during myelination (2). In our study, the ultrastructural development of oligodendrocytes was studied in newborn, 5-, 10-, 15-, 20-day and adult frontal cortex of the golden hamster (Mesocricetus auratus).Young and adult hamster brains were perfused with paraformaldehyde-glutaraldehyde in sodium cacodylate buffer at pH 7.3 according to the method of Peters (3). Tissue samples of layer V of the frontal cortex were post-fixed in 2% osmium tetroxide, dehydrated in acetone and embedded in Epon-Araldite resin.

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