scholarly journals Morphology and Microcirculation Changes of Optic Nerve Head Between Simple High Myopia and Pathologic Myopia

2021 ◽  
Author(s):  
Wenquan Tang ◽  
Xuanchu Duan ◽  
Junyi Ouyang ◽  
YuLin Luo ◽  
Xilang Wang
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
High Myopia ◽  
Structural Changes ◽  
Pathologic Myopia ◽  
Disease Development ◽  
Pathological Changes ◽  
Choroidal Perfusion ◽  
Morphology Changes

Abstract This study explored morphology and microcirculation changes of optic nerve head (ONH) in simple high myopia(SHM) and pathologic myopia(PM), in order to evaluate and identify ONH changes in the development of PM. We divided 193 right eyes of 193 patients into SHM and PM according to the retinopathy. We found that ONH is one of the earliest pathological changes in myopia, and its morphology changes were also the most obvious. PM is closely linked to the reduction of choroidal perfusion and structural changes of ONH. Microcirculation showed a significant priority changes in myopia. Further research should address whether these fndings are associated with future disease development in highly myopic eyes.

scholarly journals Glaucoma characteristics evaluation in myopia – A clinical study

2021 ◽  
Vol 7 (2) ◽  
pp. 195-199
Author(s):  
Helen Rosita J ◽  
Gnanaselvan J ◽  
Amudhavadivu S ◽  
Anna Kurian Mullasseril
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
High Myopia ◽  
Intra Ocular Pressure ◽  
Significant Difference ◽  
Long Term Follow Up ◽  
Ocular Pressure ◽  
The Mean ◽  
One Year ◽  
High Degree

Glaucoma is the leading cause of irreversible blindness, one of the risk factor recognised being high myopia. Intra ocular pressure may be normal in myopic patients, with optic nerve head glaucoma characteristics. Eye ball elongation and optic nerve head tilting may be present in patients with high myopia that will represent field defects mimicking glaucoma. Treating patients with myopia having suspected aspects of glaucoma may be a challenge but even more challenging is the diagnosis of glaucoma in myopic patients.: To evaluate the association of glaucoma features with myopia. To create the awareness regarding the long term follow up.: Patients in the age group of 15 to 45 years who had attended our institution over a period of one year who fulfilled the inclusion and exclusion criteria were subjected for this study. Fifty four patients who were diagnosed to have moderate or high degree myopia were selected for this analytical study. They were subjected to vision, ocular examination, tonometry and results obtained were analysed.: In our study moderate myopes constituted 55.5% and high myopes were 44.5%. The mean Intra ocular pressure and the mean corrected Intra ocular pressure in high myopes were observed to be higher than in moderate myopia. It was observed that higher prevalence of glaucoma was observed in high myopes.: There is a clinically as well as statistically significant difference between mean Intra ocular pressure and mean corrected Intra ocular pressure. So mean corrected Intra ocular pressure should be measured .From our study, there is a clear indication that there is increased prevalence of glaucoma in high myopes.

scholarly journals Longitudinal assessment of optic nerve head changes using optical coherence tomography in a primate microbead model of ocular hypertension

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Anita S. Y. Chan ◽  
Tin Aung Tun ◽  
John C. Allen ◽  
Myoe Naing Lynn ◽  
Sai Bo Bo Tun ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Nerve ◽  
Ocular Hypertension ◽  
Optic Nerve Head ◽  
Structural Damage ◽  
Structural Changes ◽  
Lamina Cribrosa ◽  
Optical Coherence ◽  
Longitudinal Assessment ◽  
The Mean

Abstract In humans, the longitudinal characterisation of early optic nerve head (ONH) damage in ocular hypertension (OHT) is difficult as patients with glaucoma usually have structural ONH damage at the time of diagnosis. Previous studies assessed glaucomatous ONH cupping by measuring the anterior lamina cribrosa depth (LCD) and minimal rim width (MRW) using optical coherence tomography (OCT). In this study, we induced OHT by repeated intracameral microbead injections in 16 cynomolgus primates (10 unilateral; 6 bilateral) and assessed the structural changes of the ONH longitudinally to observe early changes. Elevated intraocular pressure (IOP) in OHT eyes was maintained for 7 months and serial OCT measurements were performed during this period. The mean IOP was significantly elevated in OHT eyes when compared to baseline and compared to the control eyes. Thinner MRW and deeper LCD values from baseline were observed in OHT eyes with the greatest changes seen between month 1 and month 2 of OHT. Both the mean and maximum IOP values were significant predictors of MRW and LCD changes, although the maximum IOP was a slightly better predictor. We believe that this model could be useful to study IOP-induced early ONH structural damage which is important for understanding glaucoma pathogenesis.

Association Between Optic Nerve Head Deformation and Retinal Microvasculature in High Myopia

2018 ◽  
Vol 188 ◽  
pp. 81-90 ◽  
Author(s):  
Mi Sun Sung ◽  
Tae Hee Lee ◽  
Hwan Heo ◽  
Sang Woo Park
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
High Myopia ◽  
Retinal Microvasculature

scholarly journals Anterior Optic Nerve Head Perfusion is Dependent on Adjacent Parapapillary Choroidal perfusion

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Kyoung Min Lee ◽  
Joon Mo Kim ◽  
Eun Ji Lee ◽  
Tae-Woo Kim
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Choroidal Perfusion

scholarly journals Macular Optical Coherence Tomography Imaging in Glaucoma

2021 ◽  
Author(s):  
Alireza Kamalipour ◽  
Sasan Moghimi
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Structural Changes ◽  
Posterior Segment ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Tomography Imaging ◽  
Optical Coherence Tomography Imaging ◽  
Peripapillary Area

The advent of spectral-domain optical coherence tomography has played a transformative role in posterior segment imaging of the eye. Traditionally, images of the optic nerve head and the peripapillary area have been used to evaluate the structural changes associated with glaucoma. Recently, there is growing evidence in the literature supporting the use of macular spectral-domain optical coherence tomography as a complementary tool for clinical evaluation and research purposes in glaucoma.

scholarly journals Evaluation of retinal nerve fiber layer thickness parameters in myopic population using scanning laser polarimetry (GDxVCC)

2013 ◽  
Vol 5 (1) ◽  
pp. 3-8
Author(s):  
Tanuj Dada ◽  
A Aggarwal ◽  
SJ Bali ◽  
A Sharma ◽  
BM Shah ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Optic Nerve Head ◽  
High Myopia ◽  
Scanning Laser ◽  
Scanning Laser Polarimetry ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Laser Polarimetry

Introduction: Myopia presents a significant challenge to the ophthalmologist as myopic discs are often large, tilted, with deep cups and have a thinner neuroretinal rim all of which may mimic glaucomatous optic nerve head changes causing an error in diagnosis. Objective: To evaluate the retinal fiber layer (RNFL) thickness in low, moderate and high myopia using scanning laser polarimetry with variable corneal compensation (GDxVCC). Subjects and methods: One hundred eyes of 100 emmetropes, 30 eyes of low myopes (0 to - 4 D spherical equivalent(SE), 45 eyes with moderate myopia (- 4 to - 8D SE), and 30 eyes with high myopia (- 8 to - 15D SE) were subjected to retinal nerve fiber layer assessment using the scanning laser polarimetry (GDxVCC) in all subjects using the standard protocol. Subjects with IOP > 21 mm Hg, optic nerve head or visual field changes suggestive of glaucoma were excluded from the study. The major outcome parameters were temporal-superior-nasal-inferiortemporal (TSNIT) average, the superior and inferior average and the nerve fibre indicator (NFI). Results: The TSNIT average (p = 0.009), superior (p = 0.001) and inferior average (p = 0.008) were significantly lower; the NFI was higher (P < 0.001) in moderate myopes as compared to that in emmetropes. In high myopia the RNFL showed supranormal values; the TSNIT average, superior and inferior average was significantly higher(p < 0.001) as compared to that in emmetropes. Conclusion: The RNFL measurements on scanning laser polarimetry are affected by the myopic refractive error. Moderate myopes show a significant thinning of the RNFL. In high myopia due to peripapillary chorioretinal atrophy and contribution of scleral birefringence, the RNFL values are abnormally high. These findings need to be taken into account while assessing and monitoring glaucoma damage in moderate to high myopes on GDxVCC. Nepal J Ophthalmol 2013; 5(9):3-8 DOI: http://dx.doi.org/10.3126/nepjoph.v5i1.7814

Application of second harmonic imaging microscopy to assess structural changes in optic nerve head structure ex vivo

2007 ◽  
Vol 12 (2) ◽  
pp. 024029 ◽  
Author(s):  
Donald J. Brown ◽  
Naoyuki Morishige ◽  
Aneesh Neekhra ◽  
Don S. Minckler ◽  
James V. Jester
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Structural Changes ◽  
Ex Vivo ◽  
Second Harmonic ◽  
Harmonic Imaging
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