Long-term Outcomes of Boston Type 1 Keratoprosthesis Implantation

Introduction: The universal classification (UC) of AMI aims to facilitate cross-study analysis, yet the long-term outcomes using UC are largely unknown. Hypothesis: We tested the hypothesis that the long-term outcome of patients with AMI is better predicted by UC than ST segment classification. Methods: We conducted a prospective study of 348 consecutive patients with AMI with mean follow-up of 30.6 months. The primary outcome was the major adverse cardiovascular events (MACE) [composite of all causes of mortality, recurrent AMI, and stroke]. Multivariate and survival analysis of MACE was performed. Results: The study population was STEMI=168, NSTEMI=180, Type 1=278, Type 2=55, Type 3=5, Type 4a=2, Type 4b=5, and Type 5=3. During follow-up 80 patients died, 31 had an AMI, and 7 had a stroke. UC correlates with the ST segment classification (p<0.005). MACE free survival was different for Type 1 and Type 2 (p=0.043), but not for STEMI and NSTEMI. There was a positive association between MACE and the quartile of peak Troponin, number of cardiovascular risk factors, and number of vascular beds affected, and an inverse relationship with the utilization of discharge cardiovascular protective medications (all p≤0.01). No such inverse relationship existed for Type 2. Conclusions: UC of AMI is a better long-term predictor of MACE. The quartile of peak Troponin levels, cardiovascular risk factors, and number of vascular beds affected are independent predictors of MACE, while cardiac medications protect against MACE, except in Type 2 patients.

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Clinical characteristics and long-term outcomes of moyamoya syndrome associated with neurofibromatosis type 1

Journal of Clinical Neuroscience ◽

10.1016/j.jocn.2014.05.046 ◽

2015 ◽

Vol 22 (2) ◽

pp. 286-290 ◽

Cited By ~ 11

Author(s):

Cong Han ◽

Wei-Zhong Yang ◽

Hong-Tao Zhang ◽

Ting Ye ◽

Lian Duan

Keyword(s):

Neurofibromatosis Type 1 ◽

Clinical Characteristics ◽

Neurofibromatosis Type ◽

Moyamoya Syndrome ◽

Long Term Outcomes

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Surgery for multiple endocrine neoplasia type 1-related insulinoma: long-term outcomes in a large international cohort

British Journal of Surgery ◽

10.1002/bjs.11632 ◽

2020 ◽

Author(s):

D. J. van Beek ◽

S. Nell ◽

H. M. Verkooijen ◽

I. H. M. Borel Rinkes ◽

G. D. Valk ◽

...

Keyword(s):

Multiple Endocrine Neoplasia ◽

Multiple Endocrine Neoplasia Type ◽

Long Term Outcomes ◽

Endocrine Neoplasia ◽

Endocrine Neoplasia Type

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Long-term outcomes for children with an incidentally discovered Chiari malformation type 1: what is the clinical significance?

Child s Nervous System ◽

10.1007/s00381-020-04980-1 ◽

2020 ◽

Author(s):

Laurence Davidson ◽

Tiffany N. Phan ◽

John S. Myseros ◽

Suresh N. Magge ◽

Chima Oluigbo ◽

...

Keyword(s):

Clinical Significance ◽

Chiari Malformation ◽

Long Term Outcomes ◽

Outcomes For Children ◽

Chiari Malformation Type 1

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Comparative Analysis of the Clinical Features and Long-Term Outcomes of Pachychoroid Neovasculopathy and Type 1 Neovascular Age-Related Macular Degeneration

Journal of Ophthalmology ◽

10.1155/2020/8865743 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6

Author(s):

Jong In You ◽

Kiyoung Kim

Keyword(s):

Macular Degeneration ◽

Age Related Macular Degeneration ◽

Long Term Outcomes ◽

Age Related ◽

Treatment Naïve ◽

History Of ◽

Pachychoroid Neovasculopathy

Purpose. To evaluate the clinical characteristics and long-term prognosis of pachychoroid neovasculopathy (PCN) when compared with type 1 neovascular age-related macular degeneration (nAMD). Methods. We retrospectively analyzed 30 and 60 patients whose eyes were diagnosed as treatment-naïve PCN or type 1 nAMD, respectively. All subjects were followed up for 5 years. Baseline angiographic characteristics and long-term clinical outcomes were compared between the two groups. Results. PCN group consisted of patients of younger age and represented more choroidal vascular hyperpermeability, polypoidal lesion, and history of central serous chorioretinopathy (CSC) at the time of diagnosis (all p < 0.01). During the 5-year follow-up period, individuals in the PCN group received significantly fewer injections and reported better visual acuity compared to individuals in the type 1 nAMD group. A progressive decrease in the subfoveal choroidal thickness was observed in the type 1 nAMD group, while the thick choroid was maintained in the PCN group during the 5-year follow-up period. Conclusions. PCN developed in younger patients with a higher propensity of forming polypoidal lesions and a history of CSC. Long-term outcomes revealed that PCN had a thicker choroid and better visual prognosis with fewer number of intravitreal injection than that of type 1 nAMD.

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P3608Long-term mortality and mode of death among patients with type 1 and 2 myocardial infarction

European Heart Journal ◽

10.1093/eurheartj/ehz745.0467 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

Y Sandoval ◽

S W Smith ◽

K Schulz ◽

A Sexter ◽

F S Apple

Keyword(s):

Myocardial Infarction ◽

Coronary Artery ◽

Artery Bypass ◽

Bypass Graft ◽

Clinical Indication ◽

Prognostic Impact ◽

Long Term Outcomes ◽

Mode Of Death

Abstract Background Few studies address long-term outcomes among patients with type 2 myocardial infarction (T2MI). It has been suggested that patients with T2MI with concomitant stable ischemic heart disease are at higher-risk. Purpose Our goals were two-fold. First, to examine 5-year mortality rates and mode of death among patients with type 1 (T1MI) and T2MI. Second, to evaluate the prognostic impact of coronary artery disease (CAD) on long-term outcomes among patients with T2MI. Methods Post-hoc analysis of UTROPIA (NCT02060760), a prospective, observational cohort study involving 1,640 consecutive emergency department patients with serial cardiac troponin (cTn) I measurements obtained on clinical indication. 5-year death rates, including mode of death, were examined among patients with T1MI and T2MI. CAD was defined as the presence of any of the following: history of CAD, prior MI, prior coronary artery bypass graft surgery, prior percutaneous coronary intervention, prior coronary stenting, or documented CAD (≥50%) on index admission angiography. Results Among 1640 patients, acute MI was diagnosed in 217 patients, including 77 (4.7%) classified as T1MI and 140 (8.5%) as T2MI. At 5-years, 23% (n=18) of patients with T1MI had died, with 61% (n=11) categorized as cardiac deaths. For T2MI, 37% (n=52) had died at 5-years, with 36% (n=19) categorized as cardiac deaths. Patients with T2MI had a higher 5-year mortality than T1MI (37% vs 23%, p=0.038) (Figure, Panel A), with T2MI more likely than T1MI to die from non-cardiac causes (64% vs. 39%, p=0.04). CAD was present in 22% (n=31) of patients with T2MI and associated with worse outcomes (p=0.0496) (Figure, Panel B). Conclusion T2MI has worse long term outcomes than T1MI. The predominant mode of death among patients with T2MI is non-cardiac. However, approximately 40% of deaths are cardiac. Further, we confirm the presence of CAD identifies a subset of patients with T2MI at high-risk. Acknowledgement/Funding Abbott Diagnostics and Hennepin Healthcare Research Institute (formerly MMRF)

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