Carboxyl-ester lipase (CEL) as biomarker in pancreas cancer: Characterization of the monoclonal antibody 16D10 targeting pancreatic neoplastic cells and cross-reacting with histo-blood group A antigens

Pancreatology ◽  
2015 ◽  
Vol 15 (3) ◽  
pp. S34 ◽  
Author(s):  
Khadija El Jellas ◽  
Heike Immervoll ◽  
Ole Steffensen ◽  
Bente Berg Johansson ◽  
Karianne Fjeld ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Blood Group ◽  
Pancreas Cancer ◽  
Neoplastic Cells ◽  
Blood Group A ◽  
Group A

scholarly journals Isolation and characterization of novel glycolipids with blood group A-related structures: galactosyl-A and sialosylgalactosyl-A.

1987 ◽  
Vol 262 (29) ◽  
pp. 14228-14234
Author(s):  
H Clausen ◽  
S B Levery ◽  
E D Nudelman ◽  
M Stroud ◽  
M E Salyan ◽  
...  
Keyword(s):  
Blood Group ◽  
Blood Group A ◽  
Isolation And Characterization ◽  
Group A

Isolation and Characterization of a Blood Group A Substance-degrading α-N-Acetylgalactosaminidase from anAcremoniumsp.

1989 ◽  
Vol 53 (1) ◽  
pp. 111-120 ◽  
Author(s):  
Setsu Kadowaki ◽  
Takeshi Ueda ◽  
Kenji Yamamoto ◽  
Hidehiko Kumagai ◽  
Tatsurokuro Tochikura
Keyword(s):  
Blood Group ◽  
Blood Group A ◽  
Isolation And Characterization ◽  
Group A

scholarly journals Some monoclonal antibody reagents (C219 and JSB-1) to P-glycoprotein contain antibodies to blood group A carbohydrate determinants: a problem of quality control for immunohistochemical analysis.

1991 ◽  
Vol 39 (12) ◽  
pp. 1603-1610 ◽  
Author(s):  
C L Finstad ◽  
B W Yin ◽  
C M Gordon ◽  
M G Federici ◽  
S Welt ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Blood Group ◽  
Immunohistochemical Analysis ◽  
Blood Type ◽  
Polymorphic Variation ◽  
Blood Group A ◽  
P Glycoprotein ◽  
Apparent Correlation ◽  
Group A ◽  
Type 3

Monoclonal antibodies (MAb) C219 and JSB-1 have been used extensively in the analysis of P-glycoprotein expression in normal and malignant tissues. This study demonstrates that some commercial lots of these MAb, even those supplied as purified immunoglobulins, contain contaminating anti-A blood group antibodies. In both sources of reagent, the antibody was specific for a particular A structure, known as repetitive or Type 3 A. These observations may account for earlier studies showing polymorphic variation in P-glycoprotein expression in epithelial tissues and an apparent correlation with the A blood type of the donor. Such reactivity can be eliminated by absorption of anti-P-glycoprotein reagents with A erythrocytes. These data re-emphasize the importance of evaluating MAb samples for unsuspected contaminating antibodies.

Radioimmunotherapy of Xenografted Human Bladder Cancer Using Monoclonal Antibody against Blood Group A-Related Antigen

1988 ◽  
Vol 14 (5) ◽  
pp. 386-390 ◽  
Author(s):  
M.Y. Yeh ◽  
D.S. Yu ◽  
S.Y. Chang ◽  
C.P. Ma ◽  
S.H. Han
Keyword(s):  
Monoclonal Antibody ◽  
Bladder Cancer ◽  
Blood Group ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Blood Group A ◽  
Group A

scholarly journals Structural characterization of neutral oligosaccharides with blood-group A and H activity isolated from bovine submaxillary mucin

1991 ◽  
Vol 279 (1) ◽  
pp. 95-103 ◽  
Author(s):  
A V Savage ◽  
S M D'Arcy ◽  
C M Donoghue
Keyword(s):  
Blood Group ◽  
Methylation Analysis ◽  
Molar Ratios ◽  
Blood Group A ◽  
Group A ◽  
Bovine Submaxillary Mucin ◽  
Type 3 ◽  
Blood Group H

In this study we investigated the structures of 11 neutral oligosaccharides released from bovine submaxillary mucin by alkaline borohydride treatment and isolated by h.p.l.c. One hexa-, one penta-, three tetra-, four tri- and two di-saccharides containing core types 1, 2, 3 or 4 were obtained. We report their structures, determined by a combination of one- and two-dimensional 1H n.m.r. spectroscopy at 270 MHz and methylation analysis involving g.l.c.-m.s., along with their approximate molar ratios. Only three of these oligosaccharides have previously been reported in this source. Of the new oligosaccharides, one contains the blood-group-A antigenic determinant, two contain the blood-group-H type 2 determinant, while another contains the blood-group-H type 3 determinant. The oligosaccharide GlcNAc beta (1→6)[GlcNAc beta (1→3)]GalNAcol, although previously found as a core structure, has been isolated here as a novel trisaccharide.

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