scholarly journals Some monoclonal antibody reagents (C219 and JSB-1) to P-glycoprotein contain antibodies to blood group A carbohydrate determinants: a problem of quality control for immunohistochemical analysis.

1991 ◽  
Vol 39 (12) ◽  
pp. 1603-1610 ◽  
Author(s):  
C L Finstad ◽  
B W Yin ◽  
C M Gordon ◽  
M G Federici ◽  
S Welt ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Blood Group ◽  
Immunohistochemical Analysis ◽  
Blood Type ◽  
Polymorphic Variation ◽  
Blood Group A ◽  
P Glycoprotein ◽  
Apparent Correlation ◽  
Group A ◽  
Type 3

Monoclonal antibodies (MAb) C219 and JSB-1 have been used extensively in the analysis of P-glycoprotein expression in normal and malignant tissues. This study demonstrates that some commercial lots of these MAb, even those supplied as purified immunoglobulins, contain contaminating anti-A blood group antibodies. In both sources of reagent, the antibody was specific for a particular A structure, known as repetitive or Type 3 A. These observations may account for earlier studies showing polymorphic variation in P-glycoprotein expression in epithelial tissues and an apparent correlation with the A blood type of the donor. Such reactivity can be eliminated by absorption of anti-P-glycoprotein reagents with A erythrocytes. These data re-emphasize the importance of evaluating MAb samples for unsuspected contaminating antibodies.

scholarly journals Human Cervical Epidermal Carcinoma-associated Intracellular Localization of Glycosphingolipid with Blood Group A Type 3 Chain

1993 ◽  
Vol 84 (6) ◽  
pp. 664-672 ◽  
Author(s):  
Yongxi Cui ◽  
Hiroshi Noguchi ◽  
Kazushige Kiguchi ◽  
Daisuke Aoki ◽  
Nobuyuki Susumu ◽  
...  
Keyword(s):  
Blood Group ◽  
Intracellular Localization ◽  
Blood Group A ◽  
Group A ◽  
Type 3 ◽  
Epidermal Carcinoma

Analysis of the specificity of five murine anti-blood group A monoclonal antibodies, including one that identifies type 3 and type 4 A determinants

Biochemistry ◽  
1985 ◽  
Vol 24 (26) ◽  
pp. 7820-7826 ◽  
Author(s):  
Koichi Furukawa ◽  
Henrik Clausen ◽  
Senitiroh Hakomori ◽  
Junichi Sakamoto ◽  
Katherine Look ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Blood Group ◽  
Blood Group A ◽  
Group A ◽  
Type 3

scholarly journals DIFFERENT BLOOD GROUPS

2016 ◽  
Vol 23 (08) ◽  
pp. 1001-1004
Author(s):  
Naila Parveen ◽  
Javeria Rehman ◽  
Syed Hafeezul Hassan ◽  
Zoya Hassan ◽  
Madiha Rehman
Keyword(s):  
Body Mass Index ◽  
Medical Students ◽  
Blood Group ◽  
Body Mass ◽  
Blood Groups ◽  
Blood Type ◽  
P Value ◽  
Cross Sectional ◽  
Blood Group A ◽  
Group A

Objectives: To find out the association of body mass index with different bloodgroups in medical students. Background: Increased body mass index leads to obesity and is aprominent risk factor for hypertension and diabetes. Blood groups are known to be associatedwith various diseases and recent studies have shown that a particular blood group with thehighest body mass index appeared to be more susceptible to predisposition to hypertension.Study Design: Cross-sectional study. Setting: Liaquat National Medical College, Karachi.Period: June 2015 to September 2015. Methodology: 181 medical students with 85 malesand 96 females and age ranging from 18-22 years. Weight and height of each student wasmeasured using the standard stadiometer and blood groups were determined using the antisera.Results: Mean age of the participants was 19.92 ± 1.10 years. Blood group “O” wasfound to be most prevalent (39.2%) while blood group “AB” was found to be the least (8.3%).Mean BMI of subjects with blood group A, B, AB and O were found to be 24.3 ± 5.04, 22.6 ±3.59, 23.0 ± 2.91 and 23.7 ± 4.20 kg/m2 respectively. The highest BMI was found in subjectswith blood group “A” 24.3 ± 5.04 kg/m2 and lowest in blood group “AB” 23.0 ± 2.91kg/m2. TheRhesus-D positive and male students had greater body mass index 23.6 ± 3.56 than females23.2 ± 3.44. Comparison of overall mean BMI values among different blood groups showedsignificant difference with p-value < 0.001. Conclusion: Blood group “A” and Rhesus-D positivesubjects especially males were found to be the high risk blood type with predisposition tomorbidity associated with increased body mass index.

scholarly journals Blood Groups and their Association with Academic Performance among Medical Students in a Nepalese Medical College

2019 ◽  
Vol 41 (3) ◽  
pp. 74-77
Author(s):  
Barun Mahat ◽  
Lava Shrestha ◽  
Shailesh Adhikari ◽  
Bikalp Thapa ◽  
Prakesh Limbu ◽  
...  
Keyword(s):  
Academic Performance ◽  
Medical Students ◽  
Blood Group ◽  
Blood Groups ◽  
Blood Type ◽  
Medical College ◽  
Blood Group A ◽  
Group A ◽  
The Difference ◽  
And Behavior

Introduction Knowing a person’s blood type is not only important in transfusion medicine and forensic medicine but is also useful for predicting a person’s characteristics including intelligence, knowledge, skill and behavior. It is recognized that intelligence, knowledge and skill are assessed by performance in examination. The objective of this study was to determine distribution of blood groups among students and its association with their academic performance. MethodsThis was an analytical study that was conducted among the medical students of Nepalese Army Institutes of Health Sciences (NAIHS) in Department of Clinical Physiology from June 2014 to April 2019. This study was conducted among 738 students by using convenient sampling method. Blood group was determined on the basis of agglutination reaction. Academic performance of students was assessed by the marks obtained by them in annual final examination. ResultsBlood group O was the most prevalent at 33.5%, followed by B at 29.5%, A at 29% and AB at 8%. Distribution of Rh positive and Rh negative were 96.6% and 3.4% respectively. The mean scores obtained in final university examination were highest in blood group A (62.9%) and lowest in blood group AB (60.3%) but the difference between different blood groups was not statistically significant. ConclusionBlood group O was the most common blood group. Rh positive was present in 96.6%. Though mean score was highest in blood group A, significant association between blood groups and academic performance was not seen in our study.

Radioimmunotherapy of Xenografted Human Bladder Cancer Using Monoclonal Antibody against Blood Group A-Related Antigen

1988 ◽  
Vol 14 (5) ◽  
pp. 386-390 ◽  
Author(s):  
M.Y. Yeh ◽  
D.S. Yu ◽  
S.Y. Chang ◽  
C.P. Ma ◽  
S.H. Han
Keyword(s):  
Monoclonal Antibody ◽  
Bladder Cancer ◽  
Blood Group ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Blood Group A ◽  
Group A

scholarly journals Children with the Le(a+b−) Blood Group Have Increased Susceptibility to Diarrhea Caused by Enterotoxigenic Escherichia coli Expressing Colonization Factor I Group Fimbriae

2009 ◽  
Vol 77 (5) ◽  
pp. 2059-2064 ◽  
Author(s):  
Tanvir Ahmed ◽  
Anna Lundgren ◽  
Mohammad Arifuzzaman ◽  
Firdausi Qadri ◽  
Susann Teneberg ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Blood Group ◽  
Blood Type ◽  
Enterotoxigenic Escherichia Coli ◽  
Birth Cohort Study ◽  
Blood Group A ◽  
Lewis Blood Group ◽  
Colonization Factor ◽  
Group A ◽  
Increased Susceptibility

ABSTRACT Recent studies have shown that children with blood group A have increased susceptibility to enterotoxigenic Escherichia coli (ETEC) diarrhea and that Lewis blood group “a” antigen (Lea) may be a candidate receptor for ETEC colonization factor (CF) antigen I (CFA/I) fimbriae. Based on these findings, we have attempted to determine if children with the Le(a+b−) phenotype may be more susceptible to diarrhea caused by ETEC, in particular ETEC expressing CFA/I and related fimbriae of the CFA/I group, than Le(a−b+) children. To test this hypothesis, we have determined the Lewis antigen expression in 179 Bangladeshi children from a prospective birth cohort study in urban Dhaka in which ETEC expressing major CFs such as CFA/I, CS3, CS5, and CS6 was the most commonly isolated diarrhea pathogen during the first 2 years of life. The Lewis blood group phenotypes were determined by a dot blot immunoassay using saliva samples and by a tube agglutination test using fresh red blood cells. The results indicate that Le(a+b−) children more often had symptomatic than asymptomatic ETEC infections (P < 0.001), whereas symptomatic and asymptomatic ETEC infections were equally frequent in Le(a−b+) children. We also show that children with the Le(a+b−) blood type had significantly higher incidences of diarrhea caused by ETEC expressing fimbriae of the CFA/I group than Le(a−b+) children (P < 0.001). In contrast, we did not find any association between the Lewis blood group phenotype and diarrhea caused by ETEC expressing CS6 or rotavirus.

scholarly journals Structural characterization of neutral oligosaccharides with blood-group A and H activity isolated from bovine submaxillary mucin

1991 ◽  
Vol 279 (1) ◽  
pp. 95-103 ◽  
Author(s):  
A V Savage ◽  
S M D'Arcy ◽  
C M Donoghue
Keyword(s):  
Blood Group ◽  
Methylation Analysis ◽  
Molar Ratios ◽  
Blood Group A ◽  
Group A ◽  
Bovine Submaxillary Mucin ◽  
Type 3 ◽  
Blood Group H

In this study we investigated the structures of 11 neutral oligosaccharides released from bovine submaxillary mucin by alkaline borohydride treatment and isolated by h.p.l.c. One hexa-, one penta-, three tetra-, four tri- and two di-saccharides containing core types 1, 2, 3 or 4 were obtained. We report their structures, determined by a combination of one- and two-dimensional 1H n.m.r. spectroscopy at 270 MHz and methylation analysis involving g.l.c.-m.s., along with their approximate molar ratios. Only three of these oligosaccharides have previously been reported in this source. Of the new oligosaccharides, one contains the blood-group-A antigenic determinant, two contain the blood-group-H type 2 determinant, while another contains the blood-group-H type 3 determinant. The oligosaccharide GlcNAc beta (1→6)[GlcNAc beta (1→3)]GalNAcol, although previously found as a core structure, has been isolated here as a novel trisaccharide.

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