Neuroprotective effect of taurine in 3-nitropropionic acid-induced experimental animal model of Huntington's disease phenotype

2005 ◽  
Vol 82 (3) ◽  
pp. 574-582 ◽  
Author(s):  
Mariane G. Tadros ◽  
Amani E. Khalifa ◽  
Ashraf B. Abdel-Naim ◽  
Hossam M.M. Arafa
Keyword(s):  
Animal Model ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Experimental Animal ◽  
Neuroprotective Effect ◽  
Experimental Animal Model ◽  
Disease Phenotype ◽  
Nitropropionic Acid ◽  
3 Nitropropionic Acid

scholarly journals Increased Vulnerability to 3-Nitropropionic Acid in an Animal Model of Huntington's Disease

2002 ◽  
Vol 71 (6) ◽  
pp. 2642-2644 ◽  
Author(s):  
Mikhail B. Bogdanov ◽  
Robert J. Ferrante ◽  
Stefan Kuemmerle ◽  
Peter Klivenyi ◽  
M. Flint Beal
Keyword(s):  
Animal Model ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Nitropropionic Acid ◽  
3 Nitropropionic Acid

scholarly journals Protective Activity of Esculetin Against 3-Nitropropionic Acid Induced Neurotoxicity Via Scavenging Reactive Oxygen Species in Male Wistar Rats

2017 ◽  
Vol 9 (5) ◽  
Author(s):  
Arpita Karandikar ◽  
Sumathi Thangarajan
Keyword(s):  
Oxidative Stress ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Neurodegenerative Disorder ◽  
Neuroprotective Effect ◽  
Neuroprotective Activity ◽  
Protein Carbonyls ◽  
Rat Striatum ◽  
Nitropropionic Acid ◽  
3 Nitropropionic Acid

Huntington’s disease (HD) is a devastating neurodegenerative disorder with no cure till date. Many genetic or chemically induced models have been developed in rodents to study the disease. 3-Nitropropionic (3-NP) acid is a well-known neurotoxin to induce Huntington’s disease (HD) in rodents. It replicates the pathology of HD by causing oxidative stress. Esculetin is a natural compound, a coumarin, known to have neuroprotective effect in a mouse model of Parkinson’s disease. In the present study, the neuroprotective effect of esculetin on 3-NP induced oxidative stress in rat striatum was determined by behavioral and biochemical parameters. Rats were induced with 3-NP (10mg/kg) intraperitoneally for 14 days and rats induced with 3-NP were treated with esculetin (25mg/kg and 50mg/kg) for 14 days. Esculetin attenuated the behaviour of rats in morris water maze, open field, forced swim, narrow beam walk and grip strength test. Biochemical effect of esculetin was also studied on oxidative stress markers, SDH and acetylcholinesterase. Esculetin treatment alleviated the increased values of acetylcholinesterase, protein carbonyls and lipid peroxidation. On treatment with esculetin, we observed that the levels of SOD, GSH, catalase, glutathione peroxidase, SDH were increased. The present study shows that the antioxidant activity of esculetin may be responsible for its neuroprotective activity against 3- nitropropionic acid induced neurotoxicity in rats

Neuroprotective effect of nicotine against 3-nitropropionic acid (3-NP)-induced experimental Huntington's disease in rats

2005 ◽  
Vol 67 (1-2) ◽  
pp. 161-168 ◽  
Author(s):  
Mohammad Tariq ◽  
Haseeb Ahmad Khan ◽  
Ibrahim Elfaki ◽  
Saleh Al Deeb ◽  
Khalaf Al Moutaery
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Neuroprotective Effect ◽  
Nitropropionic Acid ◽  
3 Nitropropionic Acid

scholarly journals 3-Nitropropionic Acid and Similar Nitrotoxins

2000 ◽  
Vol 43 (1) ◽  
pp. 9-13 ◽  
Author(s):  
Jiří Patočka ◽  
Jiří Bielavský ◽  
Jiří Cabal ◽  
Josef Fusek
Keyword(s):  
Animal Model ◽  
Electron Transport ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Energy Deficit ◽  
Cellular Energy ◽  
Nitropropionic Acid ◽  
Fungal Toxins ◽  
3 Nitropropionic Acid

3-Nitropropionic acid as well as 3-nitro-1-propanol and its β-D-glucopyranoside (miserotoxin) are the plant and fungal toxins reported to interrupt mitochondrial electron transport resulting in cellular energy deficit. These nitrotoxins induce neurological degeneration in ruminants and humans. 3-Nitropropionic acid-intoxicated rats serve as the animal model for Huntington’s disease.

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