Effects of esomeprazole on healing of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers in the presence of a continued NSAID treatment: Characterization of molecular mechanisms

2011 ◽  
Vol 63 (1) ◽  
pp. 59-67 ◽  
Author(s):  
Matteo Fornai ◽  
Rocchina Colucci ◽  
Luca Antonioli ◽  
Oriana Awwad ◽  
Clara Ugolini ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Gastric Ulcers ◽  
Nsaid Treatment ◽  
Inflammatory Drug ◽  
Anti Inflammatory

Synthesis and Characterization of Metabolites and Potential Impurities of Balsalazide Disodium, an Anti-Inflammatory Drug

2010 ◽  
Vol 40 (15) ◽  
pp. 2241-2253 ◽  
Author(s):  
Md. Umar Khan ◽  
M. A. Baseer ◽  
S. Ranjith Kumar ◽  
M. Saravanakumar ◽  
A. G. Prasannanjali ◽  
...  
Keyword(s):  
Synthesis And Characterization ◽  
Inflammatory Drug ◽  
Anti Inflammatory

scholarly journals Superiority of Lansoprazole vs Ranitidine in Healing Nonsteroidal Anti-inflammatory Drug–Associated Gastric Ulcers

2000 ◽  
Vol 160 (10) ◽  
pp. 1455 ◽  
Author(s):  
Naurang M. Agrawal ◽  
Donald R. Campbell ◽  
Michael A. Safdi ◽  
Nancy L. Lukasik ◽  
Bidan Huang ◽  
...  
Keyword(s):  
Gastric Ulcers ◽  
Inflammatory Drug ◽  
Anti Inflammatory

Berberine inhibits lipopolysaccharide-induced expression of inflammatory cytokines by suppressing TLR4-mediated NF-ĸB and MAPK signaling pathways in rumen epithelial cells of Holstein calves

2019 ◽  
Vol 86 (2) ◽  
pp. 171-176 ◽  
Author(s):  
Chenxu Zhao ◽  
Yazhou Wang ◽  
Xue Yuan ◽  
Guoquan Sun ◽  
Bingyu Shen ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Signaling Pathways ◽  
Inflammatory Cytokines ◽  
Molecular Mechanisms ◽  
Mapk Signaling ◽  
Dependent Manner ◽  
Inflammatory Drug ◽  
Anti Inflammatory ◽  
Mapk Signaling Pathways ◽  
Rumen Epithelial Cells

AbstractSubacute ruminal acidosis (SARA) can increase the level of inflammation and induce rumenitis in dairy cows. Berberine (BBR) is the major active component of Rhizoma Coptidis, which is a type of Chinese anti-inflammatory drug for gastrointestinal diseases. The purpose of this study was to investigate the anti-inflammatory effects of BBR on lipopolysaccharide (LPS)-stimulated rumen epithelial cells (REC) and the underlying molecular mechanisms. REC were cultured and stimulated with LPS in the presence or absence of different concentrations of BBR. The results showed that cell viability was not affected by BBR. Moreover, BBR markedly decreased the concentrations and mRNA expression of pro-inflammatory cytokines, including tumor necrosis factor-α, interleukin-1β, and interleukin-6 in the LPS-treated REC in a dose-dependent manner. Importantly, Western blotting analysis showed that BBR significantly suppressed the protein expression of toll-like receptor 4 (TLR4) and myeloid differentiation primary response protein (MyD88) and the phosphorylation of nuclear factor-κB (NF-κB), inhibitory kappa B (IκBα), p38 mitogen-activated protein kinase (MAPK), and c-Jun N-terminal kinase (JNK) in LPS-treated REC. Furthermore, the results of immunocytofluorescence showed that BBR significantly inhibited the nuclear translocation of NF-κB p65 induced by LPS treatment. In conclusion, the protective effects of BBR on LPS-induced inflammatory responses in REC may be due to its ability to suppress the TLR4-mediated NF-κB and MAPK signaling pathways. These findings suggest that BBR can be used as an anti-inflammatory drug to treat inflammation induced by SARA.

Development, in-vitro and in-vivo characterization of gelatin nanoparticles for delivery of an anti-inflammatory drug

2016 ◽  
Vol 36 ◽  
pp. 55-61 ◽  
Author(s):  
Alok Mahor ◽  
Sunil Kumar Prajapati ◽  
Amita Verma ◽  
Rishikesh Gupta ◽  
Thakur Raghu Raj Singh ◽  
...  
Keyword(s):  
Gelatin Nanoparticles ◽  
Inflammatory Drug ◽  
Anti Inflammatory ◽  
Development In Vitro ◽  
In Vivo Characterization

Synthesis and solid-state characterization of diclofenac imidazolium monohydrate: an imidazolium pharmaceutical ionic liquid

CrystEngComm ◽  
2020 ◽  
Vol 22 (32) ◽  
pp. 5345-5354
Author(s):  
Cecilia C. P. da Silva ◽  
Bolaji C. Dayo Owoyemi ◽  
Benedito R. Alvarenga-Jr ◽  
Natalia Alvarez ◽  
Javier Ellena ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Solid State ◽  
Solvent Evaporation ◽  
Inflammatory Drug ◽  
Hydrated Salt ◽  
Anti Inflammatory ◽  
Solid State Characterization

A new imidazolium hydrated salt (DCF–IMI–H2O) of the nonsteroidal anti-inflammatory drug diclofenac (DCF) was synthesized by solvent evaporation.

scholarly journals Toxicoproteomic analysis of a mouse model of nonsteroidal anti-inflammatory drug-induced gastric ulcers

2012 ◽  
Vol 420 (1) ◽  
pp. 210-215 ◽  
Author(s):  
Kaname Ohyama ◽  
Akina Shiokawa ◽  
Kosei Ito ◽  
Ritsuko Masuyama ◽  
Tomoko Ichibangase ◽  
...  
Keyword(s):  
Mouse Model ◽  
Gastric Ulcers ◽  
Drug Induced ◽  
Inflammatory Drug ◽  
Anti Inflammatory

Heme Oxygenase-1 Is Protective Against Nonsteroidal Anti-inflammatory Drug–induced Gastric Ulcers

2012 ◽  
Vol 54 (4) ◽  
pp. 471-476 ◽  
Author(s):  
Aliye Uc ◽  
Xiaoyan Zhu ◽  
Brett A. Wagner ◽  
Garry R. Buettner ◽  
Daniel J. Berg
Keyword(s):  
Heme Oxygenase ◽  
Gastric Ulcers ◽  
Heme Oxygenase 1 ◽  
Drug Induced ◽  
Inflammatory Drug ◽  
Anti Inflammatory
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