ETS-1 induces Sorafenib-resistance in hepatocellular carcinoma cells via regulating transcription factor activity of PXR

2018 ◽  
Vol 135 ◽  
pp. 188-200 ◽  
Author(s):  
Zhiyi Shao ◽  
Yibo Li ◽  
Wenjie Dai ◽  
Hui Jia ◽  
Yingshi Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transcription Factor ◽  
Carcinoma Cells ◽  
Transcription Factor Activity ◽  
Factor Activity ◽  
Hepatocellular Carcinoma Cells

HBx induces the proliferation of hepatocellular carcinoma cells via AP1 over-expressed as a result of ER stress

2015 ◽  
Vol 466 (1) ◽  
pp. 115-121 ◽  
Author(s):  
Hyun Kook Cho ◽  
So Young Kim ◽  
Yi Yi Kyaw ◽  
Aye Aye Win ◽  
Seung-Hoi Koo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
Transcription Factor ◽  
Er Stress ◽  
Critical Role ◽  
Carcinoma Cells ◽  
Hepatocellular Carcinoma Cells

HBx protein is encoded by HBV and plays a critical role in hepatocarcinogenesis. In the present study we show that HBx activates the expression of the CREBH transcription factor and interacts with the activated CREBH. CREBH activation by HBx may result in cell proliferation.

scholarly journals MDM2 Binding Protein Induces the Resistance of Hepatocellular Carcinoma Cells to Molecular Targeting Agents via Enhancing the Transcription Factor Activity of the Pregnane X Receptor

2021 ◽  
Vol 11 ◽  
Author(s):  
Qiyu Jiang ◽  
Yan Ma ◽  
Jingjing Han ◽  
Jingdong Chu ◽  
Xuemei Ma ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transcription Factor ◽  
Binding Protein ◽  
Pregnane X Receptor ◽  
Molecular Targeting ◽  
Advanced Hepatocellular Carcinoma ◽  
Transcription Factor Activity ◽  
Factor Activity ◽  
Molecular Targeting Agents ◽  
Hcc Cells

The MDM2 binding protein (MTBP) has been considered an important regulator of human malignancies. In this study, we demonstrate that the high level of MTBP’s endogenous expression is correlated with poor prognosis of advanced hepatocellular carcinoma (HCC) patients who received sorafenib. MTBP interacted with the Pregnane X receptor (PXR) and enhanced the transcription factor activity of PXR. Moreover, MTBP enhanced the accumulation of PXR in HCC cells’ nuclear and the recruitment of PXR to its downstream gene’s (cyp3a4’s) promoter region. Mechanically, the knockdown of MTBP in MHCC97-H cells with high levels of MTBP decelerated the clearance or metabolism of sorafenib in HCC cells and led to the resistance of HCC cells to sorafenib. Whereas overexpression of MTBP in in MHCC97-L cells with low levels of MTBP showed the opposite trend. By establishing the interaction between MTBP and PXR, our results indicate that MTBP could function as a co-activator of PXR and could be a promising therapeutic target to enhance the sensitivity of HCC cells to molecular targeting agents.

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