Novel positive allosteric modulators of GABAA receptors: Do subtle differences in activity at α1 plus α5 versus α2 plus α3 subunits account for dissimilarities in behavioral effects in rats?

From Methaqualone and Beyond: Structure–Activity Relationship of 6-, 7-, and 8-Substituted 2,3-Diphenyl-quinazolin-4(3H)-ones and in Silico Prediction of Putative Binding Modes of Quinazolin-4(3H)-ones as Positive Allosteric Modulators of GABAA Receptors

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.0c00600 ◽

2020 ◽

Vol 11 (24) ◽

pp. 4362-4375

Author(s):

Peng-Fei Wang ◽

Anders A. Jensen ◽

Lennart Bunch

Keyword(s):

Gabaa Receptors ◽

In Silico ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Allosteric Modulators ◽

Binding Modes ◽

In Silico Prediction ◽

Structure Activity ◽

Relationship Of

Withdrawal from Chronic Intermittent Ethanol Treatment Changes Subunit Composition, Reduces Synaptic Function, and Decreases Behavioral Responses to Positive Allosteric Modulators of GABAA Receptors

Molecular Pharmacology ◽

10.1124/mol.63.1.53 ◽

2003 ◽

Vol 63 (1) ◽

pp. 53-64 ◽

Cited By ~ 227

Author(s):

Elisabetta Cagetti ◽

Jing Liang ◽

Igor Spigelman ◽

Richard W. Olsen

Keyword(s):

Gabaa Receptors ◽

Behavioral Responses ◽

Synaptic Function ◽

Subunit Composition ◽

Allosteric Modulators ◽

Ethanol Treatment ◽

Chronic Intermittent Ethanol ◽

Treatment Changes ◽

Anti-Tremor Action of Subtype Selective Positive Allosteric Modulators of GABAA Receptors in a Rat Model of Essential Tremors

The Cerebellum ◽

10.1007/s12311-020-01106-w ◽

2020 ◽

Vol 19 (2) ◽

pp. 265-274

Author(s):

Dipak V. Amrutkar ◽

Tino Dyhring ◽

Thomas A. Jacobsen ◽

Janus S. Larsen ◽

Karin Sandager-Nielsen

Keyword(s):

Rat Model ◽

Gabaa Receptors ◽

Allosteric Modulators ◽

Essential Tremors ◽

Subtype Selective

GABAkines – Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors

Pharmacology & Therapeutics ◽

10.1016/j.pharmthera.2021.108035 ◽

2021 ◽

pp. 108035

Author(s):

Rok Cerne ◽

Arnold Lippa ◽

Michael M. Poe ◽

Jodi L. Smith ◽

Xiaoming Jin ◽

...

Keyword(s):

Gabaa Receptors ◽

Allosteric Modulators ◽

Vasodilatory effects of a variety of positive allosteric modulators of GABAA receptors on rat thoracic aorta

European Journal of Pharmacology ◽

10.1016/j.ejphar.2021.174023 ◽

2021 ◽

Vol 899 ◽

pp. 174023

Author(s):

Milica Gajić Bojić ◽

Lidija Todorović ◽

Anja Santrač ◽

Md Yeunus Mian ◽

Dishary Sharmin ◽

...

Keyword(s):

Thoracic Aorta ◽

Gabaa Receptors ◽

Allosteric Modulators ◽

Rat Thoracic Aorta ◽

Retrochalcone derivatives are positive allosteric modulators at synaptic and extrasynaptic GABAA receptors in vitro

British Journal of Pharmacology ◽

10.1111/j.1476-5381.2010.01142.x ◽

2011 ◽

Vol 162 (6) ◽

pp. 1326-1339 ◽

Cited By ~ 8

Author(s):

Ruotian Jiang ◽

Akiko Miyamoto ◽

Adeline Martz ◽

Alexandre Specht ◽

Hitoshi Ishibashi ◽

...

Keyword(s):

Gabaa Receptors ◽

Allosteric Modulators ◽

Novel Plant Substances Acting as β Subunit Isoform-Selective Positive Allosteric Modulators of GABAA Receptors

Molecular Pharmacology ◽

10.1124/mol.105.011882 ◽

2005 ◽

Vol 68 (3) ◽

pp. 787-792 ◽

Cited By ~ 10

Author(s):

Roland Baur ◽

Urs Simmen ◽

Martin Senn ◽

Urs Séquin ◽

Erwin Sigel

Keyword(s):

Gabaa Receptors ◽

Allosteric Modulators ◽

Β Subunit ◽

Plant Substances

Development of 1,3-thiazole analogues of imidazopyridines as potent positive allosteric modulators of GABAA receptors

Bioorganic Chemistry ◽

10.1016/j.bioorg.2019.103334 ◽

2020 ◽

Vol 94 ◽

pp. 103334

Author(s):

Tatyana A. Tikhonova ◽

Irina V. Rassokhina ◽

Eugeny A. Kondrakhin ◽

Mikhail A. Fedosov ◽

Julia V. Bukanova ◽

...

Keyword(s):

Gabaa Receptors ◽

Allosteric Modulators ◽

The natural products magnolol and honokiol are positive allosteric modulators of both synaptic and extra-synaptic GABAA receptors

Neuropharmacology ◽

10.1016/j.neuropharm.2012.03.002 ◽

2012 ◽

Vol 62 (8) ◽

pp. 2507-2514 ◽

Cited By ~ 41

Author(s):

Mikhail Alexeev ◽

Denise K. Grosenbaugh ◽

David D. Mott ◽

Janet L. Fisher

Keyword(s):

Natural Products ◽

Gabaa Receptors ◽

Allosteric Modulators ◽

Behavioral Effects of α2/α3 Subtype‐Selective GABA A Receptor Positive Allosteric Modulators

The FASEB Journal ◽

10.1096/fasebj.2018.32.1_supplement.684.11 ◽

2018 ◽

Vol 32 (S1) ◽

Author(s):

Lakeisha Lewter ◽

James M. Cook ◽

Jun‐Xu Li

Keyword(s):

Behavioral Effects ◽

Allosteric Modulators ◽

Gaba A ◽

Subtype Selective