GABAkines – Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors

2021 ◽  
pp. 108035
Author(s):  
Rok Cerne ◽  
Arnold Lippa ◽  
Michael M. Poe ◽  
Jodi L. Smith ◽  
Xiaoming Jin ◽  
...  
Keyword(s):  
Gabaa Receptors ◽  
Allosteric Modulators ◽  
Positive Allosteric Modulators

Anti-Tremor Action of Subtype Selective Positive Allosteric Modulators of GABAA Receptors in a Rat Model of Essential Tremors

2020 ◽  
Vol 19 (2) ◽  
pp. 265-274
Author(s):  
Dipak V. Amrutkar ◽  
Tino Dyhring ◽  
Thomas A. Jacobsen ◽  
Janus S. Larsen ◽  
Karin Sandager-Nielsen
Keyword(s):  
Rat Model ◽  
Gabaa Receptors ◽  
Allosteric Modulators ◽  
Essential Tremors ◽  
Positive Allosteric Modulators ◽  
Subtype Selective

Vasodilatory effects of a variety of positive allosteric modulators of GABAA receptors on rat thoracic aorta

2021 ◽  
Vol 899 ◽  
pp. 174023
Author(s):  
Milica Gajić Bojić ◽  
Lidija Todorović ◽  
Anja Santrač ◽  
Md Yeunus Mian ◽  
Dishary Sharmin ◽  
...  
Keyword(s):  
Thoracic Aorta ◽  
Gabaa Receptors ◽  
Allosteric Modulators ◽  
Rat Thoracic Aorta ◽  
Positive Allosteric Modulators

scholarly journals Retrochalcone derivatives are positive allosteric modulators at synaptic and extrasynaptic GABAA receptors in vitro

2011 ◽  
Vol 162 (6) ◽  
pp. 1326-1339 ◽  
Author(s):  
Ruotian Jiang ◽  
Akiko Miyamoto ◽  
Adeline Martz ◽  
Alexandre Specht ◽  
Hitoshi Ishibashi ◽  
...  
Keyword(s):  
Gabaa Receptors ◽  
Allosteric Modulators ◽  
Positive Allosteric Modulators

Novel Plant Substances Acting as β Subunit Isoform-Selective Positive Allosteric Modulators of GABAA Receptors

2005 ◽  
Vol 68 (3) ◽  
pp. 787-792 ◽  
Author(s):  
Roland Baur ◽  
Urs Simmen ◽  
Martin Senn ◽  
Urs Séquin ◽  
Erwin Sigel
Keyword(s):  
Gabaa Receptors ◽  
Allosteric Modulators ◽  
Β Subunit ◽  
Positive Allosteric Modulators ◽  
Plant Substances

Development of 1,3-thiazole analogues of imidazopyridines as potent positive allosteric modulators of GABAA receptors

2020 ◽  
Vol 94 ◽  
pp. 103334
Author(s):  
Tatyana A. Tikhonova ◽  
Irina V. Rassokhina ◽  
Eugeny A. Kondrakhin ◽  
Mikhail A. Fedosov ◽  
Julia V. Bukanova ◽  
...  
Keyword(s):  
Gabaa Receptors ◽  
Allosteric Modulators ◽  
Positive Allosteric Modulators

scholarly journals Novel positive allosteric modulators of GABAA receptors with anesthetic activity

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Maria C. Maldifassi ◽  
Roland Baur ◽  
David Pierce ◽  
Anahita Nourmahnad ◽  
Stuart A. Forman ◽  
...  
Keyword(s):  
Gabaa Receptors ◽  
Allosteric Modulators ◽  
Anesthetic Activity ◽  
Positive Allosteric Modulators
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