A new approach to 3-miktoarm star polymers using a combination of reversible addition–fragmentation chain transfer (RAFT) and ring opening polymerization (ROP) via “Click” chemistry

Polymer ◽  
2009 ◽  
Vol 50 (13) ◽  
pp. 2768-2774 ◽  
Author(s):  
Ankit Vora ◽  
Kunal Singh ◽  
Dean C. Webster
Keyword(s):  
Click Chemistry ◽  
Ring Opening ◽  
Chain Transfer ◽  
Star Polymers ◽  
Ring Opening Polymerization ◽  
New Approach ◽  
Reversible Addition ◽  
Miktoarm Star

Synthesis of Zwitterionic Chimeric Polymersomes for Efficient Protein Loading and Intracellular Delivery

2021 ◽  
Author(s):  
bingbing zhao ◽  
Yuting Yan ◽  
Junmei Zhang ◽  
Enping Chen ◽  
Ke Wang ◽  
...  
Keyword(s):  
Ring Opening ◽  
Triblock Copolymer ◽  
Chain Transfer ◽  
Raft Polymerization ◽  
Intracellular Delivery ◽  
Ring Opening Polymerization ◽  
H Nmr ◽  
Protein Loading ◽  
Reversible Addition

A novel zwitterionic triblock copolymer of poly(dimethylamino carbonate)-polycaprolactone-poly((2-(methacryloyloxy)ethyl)dimethyl-(3-sulfopropyl)ammonium) [PAC(DMA)-PCL-PMDMSA] was designed and synthesized via sequential ring-opening polymerization (ROP) and reversible addition-fragmentation chain transfer (RAFT) polymerization successively. The 1H NMR and...

Self-Assembly of Amphiphilic Block Copolymer in Aqueous Solutions Tuned by Host-Guest Inclusion Complexation

2012 ◽  
Vol 487 ◽  
pp. 663-667
Author(s):  
Yu Long Shuai ◽  
Mi Zhou ◽  
Xin Qian
Keyword(s):  
Block Copolymer ◽  
Self Assembly ◽  
Ring Opening ◽  
Chain Transfer ◽  
Gene Transfection ◽  
Inclusion Complexation ◽  
Ring Opening Polymerization ◽  
Isopropyl Acrylamide ◽  
Reversible Addition ◽  
Copolymer Poly

The block copolymer poly (ε-caprolactone)-b-poly (N-isopropyl acrylamide) (PCL-b-PNIPAM) is synthesized via the combination of ring-opening polymerization (ROP) and reversible addition-fragmentation chain transfer (RAFT). PCL-b-PNIPAM can self-assemble into the micelles taking PCL as the cores and PNIPAM as the shells. Add α-CD into the micelles, because the inclusion complexation of α-CD to PCL chains and phenols is stronger than that to PCL, to regulate the hydrophilic and hydrophobic features of PCL chain. So PCL-b-PNIPAM block copolymers have potential application in drug delivery and gene transfection.

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