Amphiphilic Block Copolymers
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Nano Letters ◽  
2021 ◽  
Yunpeng Feng ◽  
Sean P. Quinnell ◽  
Alison M. Lanzi ◽  
Arturo J. Vegas

2021 ◽  
pp. 102816
Alexander Joseph Cunningham ◽  
Xiantao Feng ◽  
Hu Zhang ◽  
Xavier Banquy ◽  
Jeanne Leblond Chain ◽  

2021 ◽  
pp. 2100354
Haohui Huo ◽  
Zepeng Li ◽  
Tianyi Tan ◽  
Long Chen ◽  
Goran Ungar ◽  

2021 ◽  
Vol 44 ◽  
pp. 100477
Troels Røn ◽  
Irakli Javakhishvili ◽  
Seonghyeon Jeong ◽  
Katja Jankova ◽  
Seunghwan Lee

Polymers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 2607
Aleksander Forys ◽  
Maria Chountoulesi ◽  
Barbara Mendrek ◽  
Tomasz Konieczny ◽  
Theodore Sentoukas ◽  

The investigation of properties of amphiphilic block copolymers as stabilizers for non-lamellar lyotropic liquid crystalline nanoparticles represents a fundamental issue for the formation, stability and upgraded functionality of these nanosystems. The aim of this work is to use amphiphilic block copolymers, not studied before, as stabilizers of glyceryl monooleate 1-(cis-9-octadecenoyl)-rac-glycerol (GMO) colloidal dispersions. Nanosystems were prepared with the use of poly(ethylene oxide)-b-poly(lactic acid) (PEO-b-PLA) and poly(ethylene oxide)-b-poly(5-methyl-5-ethyloxycarbonyl-1,3-dioxan-2-one) (PEO-b-PMEC) block copolymers. Different GMO:polymer molar ratios lead to formulation of nanoparticles with different size and internal organization, depending on the type of hydrophobic block. Resveratrol was loaded into the nanosystems as a model hydrophobic drug. The physicochemical and morphological characteristics of the prepared nanosystems were investigated by dynamic light scattering (DLS), cryogenic transmission electron microscopy (cryo-TEM), fast Fourier transform (FFT) analysis and X-ray diffraction (XRD). The studies allowed the description of the lyotropic liquid crystalline nanoparticles and evaluation of impact of copolymer composition on these nanosystems. The structures formed in GMO:block copolymer colloidal dispersions were compared with those discussed previously. The investigations broaden the toolbox of polymeric stabilizers for the development of this type of hybrid polymer/lipid nanostructures.

Langmuir ◽  
2021 ◽  
Lei Jin ◽  
Chung-Hao Liu ◽  
Daniel Cintron ◽  
Qiang Luo ◽  
Mu-Ping Nieh ◽  

2021 ◽  
pp. 116998
Zhinan Fu ◽  
Yiming Wang ◽  
Fen Li ◽  
Xiaofeng Niu ◽  
Li Li ◽  

Jin Kyung Park ◽  
Madhumita Patel ◽  
Zhengyu Piao ◽  
So-Jung Park ◽  
Byeongmoon Jeong

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3648
Jiali Zhai ◽  
Bo Fan ◽  
San H. Thang ◽  
Calum J. Drummond

Non-lamellar lyotropic liquid crystalline (LLC) lipid nanoparticles contain internal multidimensional nanostructures such as the inverse bicontinuous cubic and the inverse hexagonal mesophases, which can respond to external stimuli and have the potential of controlling drug release. To date, the internal LLC mesophase responsiveness of these lipid nanoparticles is largely achieved by adding ionizable small molecules to the parent lipid such as monoolein (MO), the mixture of which is then dispersed into nanoparticle suspensions by commercially available poly(ethylene oxide)–poly(propylene oxide) block copolymers. In this study, the Reversible Addition-Fragmentation chain Transfer (RAFT) technique was used to synthesize a series of novel amphiphilic block copolymers (ABCs) containing a hydrophilic poly(ethylene glycol) (PEG) block, a hydrophobic block and one or two responsive blocks, i.e., poly(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acrylate) (PTBA) and/or poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA). High throughput small angle X-ray scattering studies demonstrated that the synthesized ABCs could simultaneously stabilize a range of LLC MO nanoparticles (vesicles, cubosomes, hexosomes, inverse micelles) and provide internal particle nanostructure responsiveness to changes of hydrogen peroxide (H2O2) concentrations, pH and temperature. It was found that the novel functional ABCs can substitute for the commercial polymer stabilizer and the ionizable additive in the formation of next generation non-lamellar lipid nanoparticles. These novel formulations have the potential to control drug release in the tumor microenvironment with endogenous H2O2 and acidic pH conditions.

2021 ◽  
Vol 9 ◽  
Xiaohui Yang ◽  
Wanlong Lu ◽  
Jingning Cao ◽  
Chenyang Zhai ◽  
Weili Li ◽  

The preparation of micron- to nanometer-sized functional materials with well-defined shapes and packing is a key process to their applications. There are many ways to control the crystal growth of organic semiconductors. Adding polymer additives has been proven a robust strategy to optimize semiconductor crystal structure and the corresponding optoelectronic properties. We have found that poly(3-hexylthiophene) (P3HT) can effectively regulate the crystallization behavior of N,N′-dioctyl perylene diimide (C8PDI). In this study, we combined P3HT and polyethylene glycol (PEG) to amphiphilic block copolymers and studied the crystallization modification effect of these block copolymers. It is found that the crystallization modification effect of the block copolymers is retained and gradually enhanced with P3HT content. The length of C8PDI crystals were well controlled from 2 to 0.4 μm, and the width from 210 to 35 nm. On the other hand, due to the water solubility of PEG block, crystalline PEG-b-P3HT/C8PDI micelles in water were successfully prepared, and this water phase colloid could be stable for more than 2 weeks, which provides a new way to prepare pollution-free aqueous organic semiconductor inks for printing electronic devices.

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