amphiphilic block copolymers
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Polymers ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 250
Author(s):  
Chih-Hao Chang ◽  
Chih-Hung Chang ◽  
Ya-Wen Yang ◽  
Hsuan-Yu Chen ◽  
Shu-Jyuan Yang ◽  
...  

In this study, a novel polystyrene-block-quaternized polyisoprene amphipathic block copolymer (PS-b-PIN) is derived from anionic polymerization. Quaternized polymers are prepared through post-quaternization on a functionalized polymer side chain. Moreover, the antibacterial activity of quaternized polymers without red blood cell (RBCs) hemolysis can be controlled by block composition, side chain length, and polymer morphology. The solvent environment is highly related to the polymer morphology, forming micelles or other structures. The polymersome formation would decrease the hemolysis and increase the electron density or quaternized groups density as previous research and our experiment revealed. Herein, the PS-b-PIN with N,N-dimethyldodecylamine as side chain would form a polymersome structure in the aqueous solution to display the best inhibiting bacterial growth efficiency without hemolytic effect. Therefore, the different single-chain quaternized groups play an important role in the antibacterial action, and act as a controllable factor.


Langmuir ◽  
2022 ◽  
Author(s):  
Takuya Yamamoto ◽  
Yuki Masuda ◽  
Yasuyuki Tezuka ◽  
Evgeniya Korchagina ◽  
Françoise M. Winnik

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1833
Author(s):  
Jingxin Shao ◽  
Shoupeng Cao ◽  
Hanglong Wu ◽  
Loai Abdelmohsen ◽  
Jan van Hest

Bowl-shaped biodegradable polymersomes, or stomatocytes, have much potential as drug delivery systems, due to their intriguing properties, such as controllable size, programmable morphology, and versatile cargo encapsulation capability. In this contribution, we developed well-defined therapeutically active stomatocytes with aggregation-induced emission (AIE) features by self-assembly of biodegradable amphiphilic block copolymers, comprising poly(ethylene glycol) (PEG) and AIEgenic poly(trimethylene carbonate) (PTMC) moieties. The presence of the AIEgens endowed the as-prepared stomatocytes with intrinsic fluorescence, which was employed for imaging of cellular uptake of the particles. It simultaneously enabled the photo-mediated generation of reactive oxygen species (ROS) for photodynamic therapy. The potential of the therapeutic stomatocytes as cargo carriers was demonstrated by loading enzymes (catalase and glucose oxidase) in the nanocavity, followed by a cross-linking reaction to achieve stable encapsulation. This provided the particles with a robust motile function, which further strengthened their therapeutic effect. With these unique features, enzyme-loaded AIEgenic stomatocytes are an attractive platform to be exploited in the field of nanomedicine.


2021 ◽  
Vol 22 (21) ◽  
pp. 11457
Author(s):  
Mariia Levit ◽  
Alena Vdovchenko ◽  
Apollinariia Dzhuzha ◽  
Natalia Zashikhina ◽  
Elena Katernyuk ◽  
...  

The self-assembly of amphiphilic block-copolymers is a convenient way to obtain soft nanomaterials of different morphology and scale. In turn, the use of a biomimetic approach makes it possible to synthesize polymers with fragments similar to natural macromolecules but more resistant to biodegradation. In this study, we synthesized the novel bio-inspired amphiphilic block-copolymers consisting of poly(N-methacrylamido-d-glucose) or poly(N-vinyl succinamic acid) as a hydrophilic fragment and poly(O-cholesteryl methacrylate) as a hydrophobic fragment. Block-copolymers were synthesized by radical addition–fragmentation chain-transfer (RAFT) polymerization using dithiobenzoate or trithiocarbonate chain-transfer agent depending on the first monomer, further forming the hydrophilic block. Both homopolymers and copolymers were characterized by 1H NMR and Fourier transform infrared spectroscopy, as well as thermogravimetric analysis. The obtained copolymers had low dispersity (1.05–1.37) and molecular weights in the range of ~13,000–32,000. The amphiphilic copolymers demonstrated enhanced thermal stability in comparison with hydrophilic precursors. According to dynamic light scattering and nanoparticle tracking analysis, the obtained amphiphilic copolymers were able to self-assemble in aqueous media into nanoparticles with a hydrodynamic diameter of approximately 200 nm. An investigation of nanoparticles by transmission electron microscopy revealed their spherical shape. The obtained nanoparticles did not demonstrate cytotoxicity against human embryonic kidney (HEK293) and bronchial epithelial (BEAS-2B) cells, and they were characterized by a low uptake by macrophages in vitro. Paclitaxel loaded into the developed polymer nanoparticles retained biological activity against lung adenocarcinoma epithelial cells (A549).


Nano Letters ◽  
2021 ◽  
Vol 21 (18) ◽  
pp. 7495-7504
Author(s):  
Yunpeng Feng ◽  
Sean P. Quinnell ◽  
Alison M. Lanzi ◽  
Arturo J. Vegas

2021 ◽  
pp. 102816
Author(s):  
Alexander Joseph Cunningham ◽  
Xiantao Feng ◽  
Hu Zhang ◽  
Xavier Banquy ◽  
Jeanne Leblond Chain ◽  
...  

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