Solid particle motion in a standpipe as observed by Positron Emission Particle Tracking

2009 ◽  
Vol 194 (1-2) ◽  
pp. 58-66 ◽  
Author(s):  
Chian W. Chan ◽  
Jonathan Seville ◽  
Xianfeng Fan ◽  
Jan Baeyens
2009 ◽  
Vol 193 (2) ◽  
pp. 137-149 ◽  
Author(s):  
Chian W. Chan ◽  
Jonathan Seville ◽  
Xianfeng Fan ◽  
Jan Baeyens

1997 ◽  
Vol 52 (13) ◽  
pp. 2011-2022 ◽  
Author(s):  
D.J. Parker ◽  
A.E. Dijkstra ◽  
T.W. Martin ◽  
J.P.K. Seville

2009 ◽  
Vol 48 (1) ◽  
pp. 253-261 ◽  
Author(s):  
Chian W. Chan ◽  
Jonathan P. K. Seville ◽  
Xianfeng Fan ◽  
Jan Baeyens

2010 ◽  
Vol 23 (11-13) ◽  
pp. 1036-1044 ◽  
Author(s):  
K.E. Cole ◽  
K.E. Waters ◽  
X. Fan ◽  
S.J. Neethling ◽  
J.J. Cilliers

2021 ◽  
pp. 110709
Author(s):  
Mark Al-Shemmeri ◽  
Kit Windows-Yule ◽  
Estefania Lopez-Quiroga ◽  
Peter J. Fryer

Pharmaceutics ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 659
Author(s):  
Konstantinos Stamatopoulos ◽  
Sharad Karandikar ◽  
Mark Goldstein ◽  
Connor O’Farrell ◽  
Luca Marciani ◽  
...  

This work used in vivo MRI images of human colon wall motion to inform a biorelevant Dynamic Colon Model (DCM) to understand the interplay of wall motion, volume, viscosity, fluid, and particle motion within the colon lumen. Hydrodynamics and particle motion within the DCM were characterized using Positron Emission Tomography (PET) and Positron Emission Particle Tracking (PEPT), respectively. In vitro PET images showed that fluid of higher viscosity follows the wall motion with poor mixing, whereas good mixing was observed for a low viscosity fluid. PEPT data showed particle displacements comparable to the in vivo data. Increasing fluid viscosity favors the net forward propulsion of the tracked particles. The use of a floating particle demonstrated shorter residence times and greater velocities on the liquid surface, suggesting a surface wave that was moving faster than the bulk liquid. The DCM can provide an understanding of flow motion and behavior of particles with different buoyancy, which in turn may improve the design of drug formulations, whereby fragments of the dosage form and/or drug particles are suspended in the proximal colon.


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