G1/260 – Correlation between switched memory B cells and development of bronchietasis in patients with Common variable immunodeficiency

2006 ◽  
Vol 7 ◽  
pp. S306-S307
Author(s):  
Asghhar Aghamohammadi ◽  
Mostafa Moin ◽  
Mohammad Vodjgani ◽  
Morteza Samadi ◽  
Abdolfattah Sarraf Nejad ◽  
...  
Keyword(s):  
B Cells ◽  
Common Variable Immunodeficiency ◽  
Memory B Cells ◽  
Common Variable

scholarly journals Patients with Common Variable Immunodeficiency Complicated by Autoimmune Phenomena Have Lymphopenia and Reduced Treg, Th17, and NK Cells

2021 ◽  
Vol 10 (15) ◽  
pp. 3356
Author(s):  
Ewa Więsik-Szewczyk ◽  
Elżbieta Rutkowska ◽  
Iwona Kwiecień ◽  
Marcelina Korzeniowska ◽  
Dariusz Sołdacki ◽  
...  
Keyword(s):  
B Cells ◽  
Nk Cells ◽  
Common Variable Immunodeficiency ◽  
Lupus Erythematosus ◽  
Memory B Cells ◽  
T Cell Subsets ◽  
Primary Immune Deficiency ◽  
Immunological Markers ◽  
Autoimmune Phenomena ◽  
Common Variable

Most patients with primary immune deficiency suffer from recurrent infections; however, paradoxical autoimmune phenomena can also manifest. The aim of this study was to identify immunological markers of autoimmune phenomena associated with common variable immunodeficiency (CVID). The study included 33 adults with CVID divided into two groups: (1) those with noninfectious autoimmune complications (CVID-C (n = 24)) and (2) those with only infectious symptoms (CVID-OI (n = 9)). Flow cytometry of peripheral blood was performed and compared with systemic lupus erythematosus (SLE) patients (n = 17) and healthy controls (n = 20). We found that all lymphocytes were lower in CVID-C and SLE. NK cells were lowest in CVID-C. Th17 cells were significantly reduced in CVID-C and SLE. Tregs were significantly lower in CVID-C and SLE. Bregs did not significantly differ between any groups. Class-switched memory B cells were significantly lower in CVID-C and CVID-OI. Lastly, plasmablasts were significantly higher in SLE. Among the T cell subsets, CVID-C patients had lower naive and recent thymic emigrant CD4+ T cells. In conclusion, reduced Treg, Th17, and NK cells are features of CVID with autoimmune complications, and class-switched memory B cells can help distinguish patients with different causes of autoimmunity. Future studies are needed to confirm whether reductions of Treg, Th17, and NK cells might be a biomarker of more complicated CVID cases.

CD21low B cells in common variable immunodeficiency do not show defects in receptor editing, but resemble tissue-like memory B cells

Blood ◽  
2010 ◽  
Vol 116 (18) ◽  
pp. 3682-3683 ◽  
Author(s):  
Mirzokhid Rakhmanov ◽  
Sylvia Gutenberger ◽  
Baerbel Keller ◽  
Michael Schlesier ◽  
Hans-Hartmut Peter ◽  
...  
Keyword(s):  
B Cells ◽  
Common Variable Immunodeficiency ◽  
Memory B Cells ◽  
Receptor Editing ◽  
Common Variable

Absence of Memory B Cells in Patients with Common Variable Immunodeficiency

2002 ◽  
Vol 103 (1) ◽  
pp. 34-42 ◽  
Author(s):  
Kazunaga Agematsu ◽  
Takeshi Futatani ◽  
Sho Hokibara ◽  
Norimoto Kobayashi ◽  
Masaya Takamoto ◽  
...  
Keyword(s):  
B Cells ◽  
Common Variable Immunodeficiency ◽  
Memory B Cells ◽  
Common Variable

The loss of IgM memory B cells correlates with clinical disease in common variable immunodeficiency

2005 ◽  
Vol 115 (2) ◽  
pp. 412-417 ◽  
Author(s):  
Rita Carsetti ◽  
Maria Manuela Rosado ◽  
Simona Donnanno ◽  
Vanessa Guazzi ◽  
Annarosa Soresina ◽  
...  
Keyword(s):  
B Cells ◽  
Common Variable Immunodeficiency ◽  
Memory B Cells ◽  
Clinical Disease ◽  
Common Variable

scholarly journals Chronic meningococcaemia and immunoglobulin A deficiency

2010 ◽  
Vol 59 (11) ◽  
pp. 1375-1378 ◽  
Author(s):  
Arnaud Theulin ◽  
Murielle Rondeau-Lutz ◽  
Cornelia Kuhnert ◽  
Julien Boileau ◽  
Jean-Christophe Weber
Keyword(s):  
B Cells ◽  
Neisseria Meningitidis ◽  
Common Variable Immunodeficiency ◽  
Clinical Presentation ◽  
Immunoglobulin A ◽  
Iga Deficiency ◽  
Memory B Cells ◽  
Igm Deficiency ◽  
Common Variable

Chronic meningococcaemia is an unusual clinical presentation of Neisseria meningitidis infection. We describe the case of a patient, who presented with total IgA deficiency and partial IgM deficiency with a low switched memory B cells count, suggestive of a borderline form of common variable immunodeficiency (CVID). The role of IgA in the protection against Neisseria meningitidis, and the link between IgA deficiency and CVID are discussed.

Immune competence and switched memory B cells in common variable immunodeficiency

2005 ◽  
Vol 116 (1) ◽  
pp. 37-41 ◽  
Author(s):  
Jimmy Ko ◽  
Lin Radigan ◽  
Charlotte Cunningham-Rundles
Keyword(s):  
B Cells ◽  
Common Variable Immunodeficiency ◽  
Memory B Cells ◽  
Immune Competence ◽  
Common Variable

scholarly journals Memory B cells in common variable immunodeficiency: Clinical associations and sex differences

2008 ◽  
Vol 128 (3) ◽  
pp. 314-321 ◽  
Author(s):  
Silvia Sánchez-Ramón ◽  
Lin Radigan ◽  
Joyce E. Yu ◽  
Susan Bard ◽  
Charlotte Cunningham-Rundles
Keyword(s):  
Sex Differences ◽  
B Cells ◽  
Common Variable Immunodeficiency ◽  
Memory B Cells ◽  
Clinical Associations ◽  
Common Variable

The EUROclass trial: defining subgroups in common variable immunodeficiency

Blood ◽  
2008 ◽  
Vol 111 (1) ◽  
pp. 77-85 ◽  
Author(s):  
Claudia Wehr ◽  
Teemu Kivioja ◽  
Christian Schmitt ◽  
Berne Ferry ◽  
Torsten Witte ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
B Cells ◽  
B Cell ◽  
Common Variable Immunodeficiency ◽  
Multicenter Trial ◽  
Memory B Cells ◽  
Granulomatous Disease ◽  
B Cell Differentiation ◽  
Cell Subpopulations ◽  
Common Variable

The heterogeneity of common variable immunodeficiency (CVID) calls for a classification addressing pathogenic mechanisms as well as clinical relevance. This European multicenter trial was initiated to develop a consensus of 2 existing classification schemes based on flowcytometric B-cell phenotyping and the clinical course. The clinical evaluation of 303 patients with the established diagnosis of CVID demonstrated a significant coincidence of granulomatous disease, autoimmune cytopenia, and splenomegaly. Phenotyping of B-cell subpopulations confirmed a severe reduction of switched memory B cells in most of the patients that was associated with a higher risk for splenomegaly and granulomatous disease. An expansion of CD21low B cells marked patients with splenomegaly. Lymphadenopathy was significantly linked with transitional B-cell expansion. Based on these findings and pathogenic consideration of B-cell differentiation, we suggest an improved classification for CVID (EUROclass), separating patients with nearly absent B cells (less than 1%), severely reduced switched memory B cells (less than 2%), and expansion of transitional (more than 9%) or CD21low B cells (more than 10%). Whereas the first group contains all patients with severe defects of early B-cell differentiation, severely reduced switched memory B cells indicate a defective germinal center development as found in inducible constimulator (ICOS) or CD40L deficiency. The underlying defects of expanded transitional or CD21low B cells remain to be elucidated. This trial is re-gistered at http://www.uniklinik-freiburg.de/zks/live/uklregister/Oeffentlich.html as UKF000308.

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