Erratum to “Psychomotor slowing in older patients with major depression: Relationships with blood flow in the caudate nucleus and white matter lesions” [Psychiatry Research: Neuroimaging 155(3)(2007)211–220]

White matter lesions (WMLs), also known as leukoaraiosis (LA) or white matter hyperintensities (WMHs), are characterized mainly by hyperintensities on T2-weighted or fluid-attenuated inversion recovery (FLAIR) images. With the aging of the population and the development of imaging technology, the morbidity and diagnostic rates of WMLs are increasing annually. WMLs are not a benign process. They clinically manifest as cognitive decline and the subsequent development of dementia. Although WMLs are important, their pathogenesis is still unclear. This review elaborates on the advances in the understanding of the pathogenesis of WMLs, focusing on anatomy, cerebral blood flow autoregulation, venous collagenosis, blood brain barrier disruption, and genetic factors. In particular, the attribution of WMLs to chronic ischemia secondary to venous collagenosis and cerebral blood flow autoregulation disruption seems reasonable. With the development of gene technology, the effect of genetic factors on the pathogenesis of WMLs is gaining gradual attention.

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Is the Location of White Matter Lesions Important in the Swallowing Function of Older Patients with Mild Stroke?

Dysphagia ◽

10.1007/s00455-018-9955-y ◽

2018 ◽

Vol 34 (3) ◽

pp. 407-414 ◽

Cited By ~ 5

Author(s):

Hyun Im Moon ◽

Gyu Seong Kim ◽

Eunchae Lee

Keyword(s):

White Matter ◽

Older Patients ◽

White Matter Lesions ◽

Swallowing Function ◽

Mild Stroke

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Relationship between blood pressure, cerebral blood flow velocity and white matter lesions in patients with hypertensive encephalopathy

Scripta Scientifica Medica ◽

10.14748/ssm.v39i1.507 ◽

2007 ◽

Vol 39 (1) ◽

pp. 39

Author(s):

Silva Andonova ◽

Dimitar Minchev

Keyword(s):

Blood Pressure ◽

Blood Flow ◽

Cerebral Blood Flow ◽

White Matter ◽

Flow Velocity ◽

Blood Flow Velocity ◽

Cerebral Blood Flow Velocity ◽

White Matter Lesions ◽

Hypertensive Encephalopathy

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Cerebral blood flow and predictors of white matter lesions in adults with Tetralogy of Fallot

2018 IEEE 15th International Symposium on Biomedical Imaging (ISBI 2018) ◽

10.1109/isbi.2018.8363812 ◽

2018 ◽

Author(s):

Yaqiong Chai ◽

Jieshen Chen ◽

Cristina Galarza ◽

MaaykeA. Sluman ◽

Botian Xu ◽

...

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

White Matter ◽

Tetralogy Of Fallot ◽

White Matter Lesions

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Pathophysiology of periventricular tissue changes with raised CSF pressure in cats

Journal of Neurosurgery ◽

10.3171/jns.1983.59.4.0606 ◽

1983 ◽

Vol 59 (4) ◽

pp. 606-611 ◽

Cited By ~ 37

Author(s):

Gary A. Rosenberg ◽

Linda Saland ◽

Walter T. Kyner

Keyword(s):

Blood Flow ◽

Steady State ◽

White Matter ◽

Caudate Nucleus ◽

Clinical Symptoms ◽

Periventricular White Matter ◽

Content Type ◽

Acute Hydrocephalus ◽

Tissue Changes ◽

Adult Cats

✓ Intraventricular pressure (IVP) is increased in the early stages of acute hydrocephalus. Pressure falls, however, when compensatory routes for cerebrospinal fluid (CSF) absorption develop. In order to better understand the pathophysiology of acute hydrocephalus, the authors performed ventriculocisternal perfusions on adult cats with outflow pressures maintained at either −5, 20, or 40 cm H2O. Cerebral blood flow (CBF) was determined by the iodoantipyrine method. Penetration of an extracellular marker, horseradish peroxidase (HRP), was visualized histologically. Capillary transfer of radiolabeled molecules from CSF to blood was measured by steady-state tissue clearance. Increased IVP had several effects: 1) significant reduction in mean CBF in the periventricular white matter; 2) penetration of the HRP into deep white matter; and 3) prolongation of steady-state tissue clearance half-time for (14C)-ethylene glycol in the caudate nucleus. Reduced blood flow to periventricular white matter and impaired molecular clearance in the caudate nucleus may contribute to the clinical symptoms in acute hydrocephalus.

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