Cognitive function in patients with primary adrenal insufficiency (Addison's disease)

Abstract. Somatostatin (250 μg as a bolus iv and 250 μg as a I h infusion) was administered to 6 patients with primary adrenal insufficiency (Addison's disease). The fall in plasma ACTH during the infusion period ranged between 0–30% with a mean reduction of 11.2 ± 11.6%. These findings suggest that with the method employed, somatostatin is not an inhibitor of ACTH secretion in a condition in which glucocorticoids are lacking.

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Premature Mortality in Patients with Addison’s Disease: A Population-Based Study

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2006-0076 ◽

2006 ◽

Vol 91 (12) ◽

pp. 4849-4853 ◽

Cited By ~ 275

Author(s):

Ragnhildur Bergthorsdottir ◽

Maria Leonsson-Zachrisson ◽

Anders Odén ◽

Gudmundur Johannsson

Keyword(s):

Survival Rate ◽

Confidence Interval ◽

Infectious Diseases ◽

Adrenal Insufficiency ◽

Addison’S Disease ◽

Population Based ◽

Addison's Disease ◽

Primary Adrenal Insufficiency ◽

Background Population

Abstract Background: The survival rate of patients with primary adrenal insufficiency (Addison’s disease) undergoing currently accepted replacement therapy is not known, although well-informed patients are considered to have a normal survival rate. In this study, we evaluated the mortality of patients with Addison’s disease in Sweden. Methods: A population-based, retrospective, observational study was performed, using the National Swedish Hospital and Cause of Death Registers, covering the period from 1987–2001. After a diagnosis of Addison’s disease, each patient was followed until the end of follow-up or death. Mortality was compared with that of the Swedish background population. Findings: We identified 1675 patients (995 women and 680 men) diagnosed with primary adrenal insufficiency. The average follow-up from initial diagnosis was 6.5 yr. Five hundred seven patients died during the study period compared with an expected 199. The risk ratio for all-cause mortality was 2.19 (confidence interval 1.91–2.51) for men and 2.86 (confidence interval 2.54–3.20) for women. The excess mortality in both men and women was attributed to cardiovascular, malignant, and infectious diseases. Concomitant diabetes mellitus was observed in 12% of the patients, but only contributed to the increased mortality to a minor extent. Interpretation: Compared with the background population, we observed that the risk ratio for death was more than 2-fold higher in patients with Addison’s disease. Cardiovascular, malignant, and infectious diseases were responsible for the higher mortality rate.

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The Role of Fludrocortisone in Cognition and Mood in Patients with Primary Adrenal Insufficiency (Addison's Disease)

Neuroendocrinology ◽

10.1159/000438791 ◽

2015 ◽

Vol 103 (3-4) ◽

pp. 315-320 ◽

Cited By ~ 9

Author(s):

Katharina Schultebraucks ◽

Katja Wingenfeld ◽

Christian Otte ◽

Marcus Quinkler

Keyword(s):

Adrenal Insufficiency ◽

Addison’S Disease ◽

Addison's Disease ◽

Primary Adrenal Insufficiency

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Challenging Diagnosis of Addison’s Disease Presenting with Adrenal Crisis

Case Reports in Endocrinology ◽

10.1155/2021/7137950 ◽

2021 ◽

Vol 2021 ◽

pp. 1-6

Author(s):

Ni Wayan Wina Dharmesti ◽

Made Ratna Saraswati ◽

Ketut Suastika ◽

Wira Gotera ◽

I Made Pande Dwipayana

Keyword(s):

Adrenal Insufficiency ◽

Adrenal Cortex ◽

Addison’S Disease ◽

Adrenal Crisis ◽

Addison's Disease ◽

Rapid Progression ◽

Circulatory Collapse ◽

Emergency Ward ◽

Primary Adrenal Insufficiency ◽

Life Threatening

Primary adrenal insufficiency, also known as Addison’s disease, is a rare but potentially fatal condition resulting from the failure of the adrenal cortex to produce glucocorticoid and/or mineralocorticoid hormones. Unfortunately, the clinical manifestation of primary adrenal insufficiency is not specific and often progresses insidiously, resulting in late diagnosis, or in severe cases, life-threatening circulatory collapse. Adrenal insufficiency should be considered in patients with unexplained vascular collapse. We report the case of a woman who presented to the emergency ward with unexplainable shock that was later diagnosed as adrenal crisis due to Addison’s disease. The presence of hyperpigmentation in patients with rapid progression of adrenal insufficiency suggests the diagnosis of Addison’s disease presenting with adrenal crisis.

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Addison’s disease associated with hypokalemia: a case report

Journal of Medical Case Reports ◽

10.1186/s13256-021-02724-6 ◽

2021 ◽

Vol 15 (1) ◽

Author(s):

M. Abdalla ◽

J. A. Dave ◽

I. L. Ross

Keyword(s):

Adrenal Insufficiency ◽

Medical Condition ◽

Addison’S Disease ◽

Severe Hypoglycemia ◽

High Plasma ◽

Addison's Disease ◽

Primary Adrenal Insufficiency ◽

Case Presentation ◽

Low Concentrations ◽

History Of

Abstract Background Primary adrenal insufficiency (Addison's disease) is a rare medical condition usually associated with hyperkalemia or normokalemia. We report a rare case of Addison's disease, coexisting with hypokalemia, requiring treatment. Case presentation In this case, a 42-year-old man was admitted to the intensive care unit with a history of loss of consciousness and severe hypoglycemia. His blood tests showed metabolic acidosis, low concentrations of cortisol 6 nmol/L (normal 68–327 nmol/L), and high plasma adrenocorticotropic hormone 253 pmol/L (normal 1.6–13.9 pmol/L), and he was diagnosed with primary adrenal insufficiency. Surprisingly, his serum potassium was low, 2.3 mmol/L (normal 3.5–5.1 mmol/L), requiring replacement over the course of his admission. Computed tomography scan of the adrenal glands showed features suggestive of unilateral adrenal tuberculosis. Investigations confirmed renal tubulopathy. The patient responded favorably to cortisol replacement, but never required fludrocortisone. Conclusions Coexistence of hypokalemia with Addison’s disease is unusual. We recommend investigation of the cause of hypokalemia in its own right, if it occurs with primary adrenal insufficiency.

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