Endocrine disrupting chemicals affect the Gonadotropin releasing hormone neuronal network

2014 ◽  
Vol 44 ◽  
pp. 73-84 ◽  
Author(s):  
Johanna K. Mueller ◽  
Sabine Heger
Keyword(s):  
Neuronal Network ◽  
Endocrine Disrupting Chemicals ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Endocrine Disrupting

scholarly journals Mechanisms of Interaction of Endocrine-Disrupting Chemicals with Glutamate-Evoked Secretion of Gonadotropin-Releasing Hormone

2007 ◽  
Vol 102 (1) ◽  
pp. 33-41 ◽  
Author(s):  
Grégory Rasier ◽  
Anne-Simone Parent ◽  
Arlette Gérard ◽  
Raphaël Denooz ◽  
Marie-Christine Lebrethon ◽  
...  
Keyword(s):  
Endocrine Disrupting Chemicals ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Endocrine Disrupting

scholarly journals Benzo[a]pyrene impairs the migratory pattern of human gonadotropin-releasing-hormone-secreting neuroblasts

2021 ◽  
Vol 65 (s1) ◽  
Author(s):  
Giulia Guarnieri ◽  
Matteo Becatti ◽  
Paolo Comeglio ◽  
Linda Vignozzi ◽  
Mario Maggi ◽  
...  
Keyword(s):  
Mrna Level ◽  
Reproductive Function ◽  
Gonadotropin Releasing Hormone ◽  
Human Reproduction ◽  
Gnrh Neuron ◽  
Releasing Hormone ◽  
Endocrine Disrupting Compound ◽  
Endocrine Disrupting ◽  
Migratory Pattern ◽  
Migratory Process

Benzo[a]pyrene (BaP) is a widespread pollutant that can act as an endocrine disrupting compound (EDC) and interferes with reproductive function. The central regulatory network of the reproductive system is mediated by gonadotropin-releasing hormone (GnRH) neurons, which originate in the olfactory placode and, during ontogenesis, migrate into the hypothalamus. Given the importance of the migratory process for GnRH neuron maturation, we investigated the effect of BaP (10 µM for 24 h) on GnRH neuroblasts isolated from the human fetal olfactory epithelium (FNCB4). BaP exposure significantly reduced the mRNA level of genes implicated in FNCB4 cell migration and affected their migratory ability. Our findings demonstrate that BaP may interfere with the central neuronal network controlling human reproduction affecting GnRH neuron maturation.

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