Inflammation and cardiorespiratory control: The role of the vagus nerve

Treatments for psoriasis and psoriatic arthritis have progressed at a rapid rate over the past 20 years, but treating patients with recalcitrant disease still remains a difficult task. Current therapies for these diseases involve topical agents, phototherapy, and systemic immunosuppression. However, the role of the nervous system in psoriasis and psoriatic arthritis remains largely unexplored. Recent animal studies and clinical trials have demonstrated that vagus nerve stimulation can decrease inflammatory processes in rheumatoid arthritis and inflammatory bowel disease. In this article, we outline the existing knowledge of the nervous system’s role in chronic inflammatory disease and discuss how these findings could be utilized in the future for treatment of psoriasis and psoriatic arthritis.

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Role of the Vagus Nerve in Fasted and Postprandial Gastic Motor Patterns in the House Musk Shrew ( Suncus Murinus ), a Small Laboratory Animal

Gastroenterology ◽

10.1016/s0016-5085(11)63597-x ◽

2011 ◽

Vol 140 (5) ◽

pp. S-866

Author(s):

Yuki Miyano ◽

Zuoyun Xie ◽

Anupom Mondal ◽

Kazuya Nishina ◽

Sen-ichi Oda ◽

...

Keyword(s):

Vagus Nerve ◽

Laboratory Animal ◽

Small Laboratory Animal ◽

Small Laboratory ◽

Suncus Murinus ◽

Motor Patterns ◽

Musk Shrew

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The role of the vagus nerve on dexmedetomidine promoting survival and lung protection in a sepsis model in rats

European Journal of Pharmacology ◽

10.1016/j.ejphar.2021.174668 ◽

2022 ◽

Vol 914 ◽

pp. 174668

Author(s):

Yumo Li ◽

Binbin Wu ◽

Cong Hu ◽

Jie Hu ◽

Qingquan Lian ◽

...

Keyword(s):

Vagus Nerve ◽

Lung Protection ◽

Sepsis Model

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393 Role of the Vagus Nerve in the Gut-Brain Axis Revealed by Stimulation and Blockade of the Gastric Vagus Nerve

Gastroenterology ◽

10.1016/s0016-5085(13)60278-4 ◽

2013 ◽

Vol 144 (5) ◽

pp. S-76

Author(s):

Helene Johannessen ◽

David Revesz ◽

Yosuke Kodama ◽

Nikki Cassie ◽

Karolina P. Skibicka ◽

...

Keyword(s):

Vagus Nerve

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Role of EDRF/NO in parasympathetic coronary vasodilation following carotid chemoreflex activation in conscious dogs

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.1994.267.2.h605 ◽

1994 ◽

Vol 267 (2) ◽

pp. H605-H613 ◽

Cited By ~ 7

Author(s):

W. Shen ◽

M. Ochoa ◽

X. Xu ◽

J. Wang ◽

T. H. Hintze

Keyword(s):

Vagus Nerve ◽

Conscious Dogs ◽

Coronary Resistance ◽

Vascular Response ◽

Coronary Vasodilation ◽

Relaxing Factor ◽

Anesthetized Dogs ◽

Endothelium Derived Relaxing Factor ◽

Stimulation Of

The role of endothelium-derived relaxing factor (EDRF) in parasympathetic coronary vasodilation following carotid chemoreflex activation induced by nicotine in conscious dogs and stimulation of the vagus nerve in anesthetized dogs was studied. Injection of nicotine (11 +/- 4 micrograms) into the carotid artery increased coronary blood flow (CBF) by 126 +/- 16% from 28 +/- 3 ml/min and reduced late diastolic coronary resistance (LDCR) by 43 +/- 4% from 3.58 +/- 0.52 mmHg.ml-1.min, accompanied by a significant increase in mean arterial pressure and a decrease in heart rate (all P < 0.01). Pacing and propranolol did not change the coronary vascular response to chemoreflex activation. There were still increases in CBF by 113 +/- 17% from 29 +/- 3 ml/min and decreases in LDCR by 41 +/- 5% from 3.13 +/- 0.52 mmHg.ml-1.min (all P < 0.01). After infusion of N omega-nitro-L-arginine (L-NNA) (30 mg/kg), the increase in CBF following chemoreflex activation was only 23 +/- 3% from 37 +/- 3 ml/min, and the fall in LDCR was 19 +/- 3% from 3.09 +/- 0.51 mmHg.ml-1.min. Stimulation of the vagus nerve showed a relationship between stimulation frequency and coronary vasodilation that was significantly inhibited by L-NNA. Thus EDRF plays an important role in mediating parasympathetic coronary vasodilation during chemoreflex activation and perhaps during many reflexes that cause vagal cholinergic vasodilation in the heart.

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